The genomics and proteomics of biofilm formation

Bacterial communities that are attached to a surface, so-called biofilms, and their inherent resistance to antimicrobial agents are a cause of many persistent and chronic bacterial infections. Recent genomic and proteomic studies have identified many of the genes and gene products differentially expressed during biofilm formation, revealing the complexity of this developmental process.

[1]  A. Chakrabarty,et al.  Exopolysaccharide production in biofilms: substratum activation of alginate gene expression by Pseudomonas aeruginosa , 1993, Applied and environmental microbiology.

[2]  J. Costerton,et al.  Bacterial biofilms in nature and disease. , 1987, Annual review of microbiology.

[3]  K. Otto,et al.  Surface sensing and adhesion of Escherichia coli controlled by the Cpx-signaling pathway , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[4]  J. Costerton,et al.  The involvement of cell-to-cell signals in the development of a bacterial biofilm. , 1998, Science.

[5]  B. Lazazzera,et al.  The sporulation transcription factor Spo0A is required for biofilm development in Bacillus subtilis , 2001, Molecular microbiology.

[6]  C. Prigent-Combaret,et al.  Involvement of the Cpx signal transduction pathway of E. coli in biofilm formation. , 1999, FEMS microbiology letters.

[7]  E. Greenberg,et al.  Identification, Timing, and Signal Specificity of Pseudomonas aeruginosa Quorum-Controlled Genes: a Transcriptome Analysis , 2003, Journal of bacteriology.

[8]  R. Hengge-aronis,et al.  Signal Transduction and Regulatory Mechanisms Involved in Control of the σS (RpoS) Subunit of RNA Polymerase , 2002, Microbiology and Molecular Biology Reviews.

[9]  K. Jarvi,et al.  Use of In-Biofilm Expression Technology To Identify Genes Involved in Pseudomonas aeruginosa Biofilm Development , 2003, Journal of bacteriology.

[10]  K. Otto,et al.  Adhesion of Type 1-Fimbriated Escherichia coli to Abiotic Surfaces Leads to Altered Composition of Outer Membrane Proteins , 2001, Journal of bacteriology.

[11]  R. Kolter,et al.  Flagellar and twitching motility are necessary for Pseudomonas aeruginosa biofilm development , 1998, Molecular microbiology.

[12]  R. Burne,et al.  Functional Genomics Approach to Identifying Genes Required for Biofilm Development by Streptococcus mutans , 2002, Applied and Environmental Microbiology.

[13]  Roger E. Bumgarner,et al.  Gene expression in Pseudomonas aeruginosa biofilms , 2001, Nature.

[14]  R. McLean,et al.  Impact of rpoS Deletion onEscherichia coli Biofilms , 1999, Applied and Environmental Microbiology.

[15]  J. Ghigo Are there biofilm-specific physiological pathways beyond a reasonable doubt? , 2003, Research in microbiology.

[16]  T. Romeo,et al.  Catabolite Repression of Escherichia coli Biofilm Formation , 2002, Journal of bacteriology.

[17]  J. Theron,et al.  Proteomic Analysis Reveals Differential Protein Expression by Bacillus cereus during Biofilm Formation , 2002, Applied and Environmental Microbiology.

[18]  J. Costerton,et al.  Pseudomonas aeruginosa Displays Multiple Phenotypes during Development as a Biofilm , 2002, Journal of bacteriology.

[19]  R. Kolter,et al.  Biofilm formation as microbial development. , 2000, Annual review of microbiology.

[20]  K. Marshall,et al.  Physiological responses induced in bacteria adhering to surfaces , 1991 .

[21]  A. Brooks,et al.  Microarray Analysis of Pseudomonas aeruginosa Quorum-Sensing Regulons: Effects of Growth Phase and Environment , 2003, Journal of bacteriology.

[22]  J. Costerton,et al.  Biofilms as complex differentiated communities. , 2002, Annual review of microbiology.

[23]  C. Prigent-Combaret,et al.  Abiotic Surface Sensing and Biofilm-Dependent Regulation of Gene Expression in Escherichia coli , 1999, Journal of bacteriology.

[24]  M. Schembri,et al.  Global gene expression in Escherichia coli biofilms , 2003, Molecular microbiology.

[25]  D. Hassett,et al.  Effect of rpoS Mutation on the Stress Response and Expression of Virulence Factors in Pseudomonas aeruginosa , 1999, Journal of bacteriology.

[26]  A. Grossman,et al.  Identification of Catabolite Repression as a Physiological Regulator of Biofilm Formation by Bacillus subtilis by Use of DNA Microarrays , 2003, Journal of bacteriology.