A case of primary Epstein‐Barr virus‐associated cutaneous diffuse large B‐cell lymphoma unassociated with iatrogenic or endogenous immune dysregulation

Cutaneous Epstein‐Barr virus (EBV)‐associated B‐cell lymphoma (EBVBL) in non‐immunocompromised patients is very rare. Here, we report a case of cutaneous EBVBL in a 72‐year‐old Japanese woman without any signs of immunosuppression. She showed repeated high fever and skin eruptions on the face, limbs and palms. Histological diagnosis was diffuse large B‐cell lymphoma. EBV infection was detected by in situ hybridization and Southern blotting. Immunostaining for viral proteins showed the patient to be positive for latent membrane protein 1 (LMP‐1) and negative for Epstein‐Barr virus nuclear antigen‐1 (EBNA‐2), indicating that a type II latency EBV infection pattern.

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