Microfluidic Culture Platforms in Neuroscience Research

[1]  Mark W. Tibbitt,et al.  Hydrogels as extracellular matrix mimics for 3D cell culture. , 2009, Biotechnology and bioengineering.

[2]  G. Banker,et al.  Local Presentation of Substrate Molecules Directs Axon Specification by Cultured Hippocampal Neurons , 1999, The Journal of Neuroscience.

[3]  A. Folch,et al.  3D-printing of transparent bio-microfluidic devices in PEG-DA. , 2016, Lab on a chip.

[4]  J. S. Coggan,et al.  Proposed evolutionary changes in the role of myelin , 2013, Front. Neurosci..

[5]  A. Kouzani,et al.  Microfluidic devices for cell cultivation and proliferation. , 2013, Biomicrofluidics.

[6]  Michael J Moore,et al.  Methods for fabrication and evaluation of a 3D microengineered model of myelinated peripheral nerve. , 2018, Journal of neural engineering.

[7]  Po Ki Yuen,et al.  SmartBuild-a truly plug-n-play modular microfluidic system. , 2008, Lab on a chip.

[8]  J. Qin,et al.  Engineering stem cell-derived 3D brain organoids in a perfusable organ-on-a-chip system , 2018, RSC advances.

[9]  Bruce C Wheeler,et al.  A modified microstamping technique enhances polylysine transfer and neuronal cell patterning. , 2003, Biomaterials.

[10]  Li Wang,et al.  Human brain organoid-on-a-chip to model prenatal nicotine exposure. , 2018, Lab on a chip.

[11]  Nicola Elvassore,et al.  Micro-bioreactor array for controlling cellular microenvironments. , 2007, Lab on a chip.

[12]  K. Nave,et al.  The role of myelin and oligodendrocytes in axonal energy metabolism , 2013, Current Opinion in Neurobiology.

[13]  Rosanne Wijdeven,et al.  Structuring a multi-nodal neural network in vitro within a novel design microfluidic chip , 2018, Biomedical microdevices.

[14]  P. Tabeling,et al.  Determining phase diagrams of gas-liquid systems using a microfluidic PVT. , 2012, Lab on a chip.

[15]  Conrad D James,et al.  Effects of substrate geometry on growth cone behavior and axon branching. , 2006, Journal of neurobiology.

[16]  Roger D. Kamm,et al.  Differentiation of Embryonic Stem Cells into Cardiomyocytes in a Compliant Microfluidic System , 2011, Annals of Biomedical Engineering.

[17]  K. Deisseroth,et al.  Targeting Neural Circuits , 2016, Cell.

[18]  Somin Lee,et al.  Modeling neural circuit, blood–brain barrier, and myelination on a microfluidic 96 well plate , 2019, Biofabrication.

[19]  Albert Folch,et al.  The upcoming 3D-printing revolution in microfluidics. , 2016, Lab on a chip.

[20]  N. Jeon,et al.  Optogenetic neuronal stimulation promotes axon outgrowth and myelination of motor neurons in a three‐dimensional motor neuron–Schwann cell coculture model on a microfluidic biochip , 2019, Biotechnology and bioengineering.

[21]  Roger D Kamm,et al.  Engineered 3D vascular and neuronal networks in a microfluidic platform , 2018, Scientific Reports.

[22]  Gang Chen,et al.  Fabrication, modification, and application of poly(methyl methacrylate) microfluidic chips , 2008, Electrophoresis.

[23]  Hae Ung Lee,et al.  Subcellular Optogenetic Stimulation for Activity-Dependent Myelination of Axons in a Novel Microfluidic Compartmentalized Platform. , 2016, ACS chemical neuroscience.

[24]  D. Ingber,et al.  Microfluidic organs-on-chips , 2014, Nature Biotechnology.

[25]  Nitish Thakor,et al.  Axon Myelination and Electrical Stimulation in a Microfluidic, Compartmentalized Cell Culture Platform , 2012, NeuroMolecular Medicine.

[26]  H. Lassmann.  Mechanisms of demyelination and tissue destruction in multiple sclerosis , 2002, Clinical Neurology and Neurosurgery.

[27]  D. Beebe,et al.  The present and future role of microfluidics in biomedical research , 2014, Nature.

[28]  Rui Liu,et al.  Spatiotemporally controlled and multifactor involved assay of neuronal compartment regeneration after chemical injury in an integrated microfluidics. , 2012, Analytical chemistry.

[29]  S. Karimi-Abdolrezaee,et al.  Myelin damage and repair in pathologic CNS: challenges and prospects , 2015, Front. Mol. Neurosci..

[30]  J. Milbrandt,et al.  Assembly and Maintenance of Nodes of Ranvier Rely on Distinct Sources of Proteins and Targeting Mechanisms , 2012, Neuron.

[31]  W. Baumann,et al.  Micropatterned Thermoresponsive Cell Culture Substrates for Dynamically Controlling Neurite Outgrowth and Neuronal Connectivity in Vitro. , 2019, ACS applied bio materials.

[32]  Spyros Darmanis,et al.  Human Astrocyte Maturation Captured in 3D Cerebral Cortical Spheroids Derived from Pluripotent Stem Cells , 2017, Neuron.

[33]  J. Kreutzer,et al.  Co-stimulation with IL-1β and TNF-α induces an inflammatory reactive astrocyte phenotype with neurosupportive characteristics in a human pluripotent stem cell model system , 2019, Scientific Reports.

[34]  Karl Deisseroth,et al.  Optogenetics enables functional analysis of human embryonic stem cell–derived grafts in a Parkinson's disease model , 2015, Nature Biotechnology.

[35]  E. Seker,et al.  A Microfluidic Platform to Study Astrocyte Adhesion on Nanoporous Gold Thin Films , 2018, Nanomaterials.

[36]  Labchan Rajbhandari,et al.  Toll/Interleukin-1 Receptor Domain-Containing Adapter Inducing Interferon-β Mediates Microglial Phagocytosis of Degenerating Axons , 2012, The Journal of Neuroscience.

[37]  Kenji Yasuda,et al.  Microtechnologies to fuel neurobiological research with nanometer precision , 2013, Journal of Nanobiotechnology.

[38]  Peng Zhang,et al.  Microfluidic platforms for cell cultures and investigations , 2019, Microelectronic Engineering.

[39]  T. Houdayer,et al.  Neuronal activity promotes myelination via a cAMP pathway , 2013, Glia.

[40]  R. Fields,et al.  White matter in learning, cognition and psychiatric disorders , 2008, Trends in Neurosciences.

[41]  Jonathan A. Bernstein,et al.  Assembly of functionally integrated human forebrain spheroids , 2017, Nature.

[42]  Shuichi Takayama,et al.  Microfluidic system for formation of PC-3 prostate cancer co-culture spheroids. , 2009, Biomaterials.

[43]  Wilhelm Pfleging,et al.  A chip-based platform for the in vitro generation of tissues in three-dimensional organization. , 2007, Lab on a chip.

[44]  Nitish V. Thakor,et al.  Neuromuscular junction in a microfluidic device , 2013, 2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC).

[45]  Brendon M. Baker,et al.  Deconstructing the third dimension – how 3D culture microenvironments alter cellular cues , 2012, Journal of Cell Science.

[46]  Z. Nie,et al.  Microfluidic 3D cell culture: potential application for tissue-based bioassays. , 2012, Bioanalysis.

[47]  Hongjun Song,et al.  Generation of human brain region–specific organoids using a miniaturized spinning bioreactor , 2018, Nature Protocols.

[48]  M. Valtorta,et al.  Reconstitution of the Human Nigro-striatal Pathway on-a-Chip Reveals OPA1-Dependent Mitochondrial Defects and Loss of Dopaminergic Synapses , 2019, Cell reports.

[49]  P. Brites,et al.  Early axonal loss accompanied by impaired endocytosis, abnormal axonal transport, and decreased microtubule stability occur in the model of Krabbe's disease , 2014, Neurobiology of Disease.

[50]  Eitan Erez Zahavi,et al.  Compartmental microfluidic system for studying muscle-neuron communication and neuromuscular junction maintenance. , 2016, European journal of cell biology.

[51]  S. Pașca,et al.  The rise of three-dimensional human brain cultures , 2018, Nature.

[52]  Kenta Shimba,et al.  A co-culture microtunnel technique demonstrating a significant contribution of unmyelinated Schwann cells to the acceleration of axonal conduction in Schwann cell-regulated peripheral nerve development. , 2017, Integrative biology : quantitative biosciences from nano to macro.

[53]  Akimasa Takeuchi,et al.  Device for co-culture of sympathetic neurons and cardiomyocytes using microfabrication. , 2011, Lab on a chip.

[54]  L. Mei,et al.  Neuromuscular Junction Formation, Aging, and Disorders. , 2018, Annual review of physiology.

[55]  Hyun-Jung Kim,et al.  Neural Stem Cell Differentiation Using Microfluidic Device-Generated Growth Factor Gradient , 2018, Biomolecules & therapeutics.

[56]  Min Zhang,et al.  A dynamic in vivo-like organotypic blood-brain barrier model to probe metastatic brain tumors , 2016, Scientific Reports.

[57]  T. Reh,et al.  Guiding the morphogenesis of dissociated newborn mouse retinal cells and hES cell-derived retinal cells by soft lithography-patterned microchannel PLGA scaffolds. , 2012, Biomaterials.

[58]  R. Kamm,et al.  Microphysiological 3D model of amyotrophic lateral sclerosis (ALS) from human iPS-derived muscle cells and optogenetic motor neurons , 2018, Science Advances.

[59]  M. Théry,et al.  Micropatterning as a tool to decipher cell morphogenesis and functions , 2010, Journal of Cell Science.

[60]  Deyu Li,et al.  A versatile valve-enabled microfluidic cell co-culture platform and demonstration of its applications to neurobiology and cancer biology , 2011, Biomedical microdevices.

[61]  Nitish Thakor,et al.  Circular compartmentalized microfluidic platform: Study of axon-glia interactions. , 2010, Lab on a chip.

[62]  Enabling single cell electrical stimulation and response recording via a microfluidic platform. , 2019, Biomicrofluidics.

[63]  J. Heath,et al.  High-throughput screening of rare metabolically active tumor cells in pleural effusion and peripheral blood of lung cancer patients , 2017, Proceedings of the National Academy of Sciences.

[64]  Klaus-Armin Nave,et al.  Myelination of the nervous system: mechanisms and functions. , 2014, Annual review of cell and developmental biology.

[65]  Karl-Heinz Krause,et al.  A 3D printed microfluidic device for production of functionalized hydrogel microcapsules for culture and differentiation of human Neuronal Stem Cells (hNSC). , 2016, Lab on a chip.

[66]  N. Jeon,et al.  Microfluidic culture platform for neuroscience research , 2006, Nature Protocols.

[67]  Jun Li,et al.  An on-chip model for investigating the interaction between neurons and cancer cells. , 2016, Integrative biology : quantitative biosciences from nano to macro.

[68]  S. Quake,et al.  Biocompatibility and reduced drug absorption of sol-gel-treated poly(dimethyl siloxane) for microfluidic cell culture applications. , 2010, Analytical chemistry.

[69]  Hanry Yu,et al.  A practical guide to microfluidic perfusion culture of adherent mammalian cells. , 2007, Lab on a chip.

[70]  Nishant Ganesh Kumar,et al.  Toll‐like receptor 4 deficiency impairs microglial phagocytosis of degenerating axons , 2014, Glia.

[71]  A. Woolley,et al.  Advances in microfluidic materials, functions, integration, and applications. , 2013, Chemical reviews.

[72]  O. Kallioniemi,et al.  High-Throughput 3D Screening Reveals Differences in Drug Sensitivities between Culture Models of JIMT1 Breast Cancer Cells , 2013, PloS one.

[73]  Hossein Baharvand,et al.  Optogenetics in the Era of Cerebral Organoids. , 2019, Trends in biotechnology.

[74]  Nitish Thakor,et al.  Valve-based microfluidic compression platform: single axon injury and regrowth. , 2011, Lab on a chip.

[75]  D. Beebe,et al.  Cell culture models in microfluidic systems. , 2008, Annual review of analytical chemistry.

[76]  M. Toner,et al.  Microengineering of cellular interactions. , 2000, Annual review of biomedical engineering.

[77]  Emmanuel Roy,et al.  Thermoplastic elastomer with advanced hydrophilization and bonding performances for rapid (30 s) and easy molding of microfluidic devices. , 2017, Lab on a chip.

[78]  A. Abate,et al.  Glass coating for PDMS microfluidic channels by sol-gel methods. , 2008, Lab on a chip.

[79]  Nikolaj Gadegaard,et al.  30 years of microfluidics , 2019, Micro and Nano Engineering.

[80]  Jeff Mellen,et al.  High-Throughput Droplet Digital PCR System for Absolute Quantitation of DNA Copy Number , 2011, Analytical chemistry.

[81]  Anja Kunze,et al.  Compartmentalized Microfluidics for In Vitro Alzheimer’s Disease Studies , 2015 .

[82]  M. Gijs,et al.  Internal modification of poly(dimethylsiloxane) microchannels with a borosilicate glass coating. , 2008, Langmuir : the ACS journal of surfaces and colloids.

[83]  Vivian M. Hernández,et al.  Microfluidics for neuroscience: Novel tools and future implications , 2012 .

[84]  Anna E. King,et al.  Microfluidic primary culture model of the lower motor neuron–neuromuscular junction circuit , 2013, Journal of Neuroscience Methods.

[85]  David C. Johnson,et al.  Herpes Simplex Virus gE/gI Extracellular Domains Promote Axonal Transport and Spread from Neurons to Epithelial Cells , 2014, Journal of Virology.

[86]  Ari Glezer,et al.  A microperfused incubator for tissue mimetic 3D cultures , 2009, Biomedical microdevices.

[87]  K. Kim,et al.  Applications of Microfluidic Devices for Urology , 2017, International neurourology journal.

[88]  Sang-Hoon Lee,et al.  Central Nervous System and its Disease Models on a Chip. , 2015, Trends in biotechnology.

[89]  S. Leach,et al.  PanIN Neuroendocrine Cells Promote Tumorigenesis via Neuronal Cross-talk. , 2017, Cancer research.

[90]  Bingcheng Lin,et al.  Microfluidics : technologies and applications , 2011 .

[91]  Hanry Yu,et al.  A novel 3D mammalian cell perfusion-culture system in microfluidic channels. , 2007, Lab on a chip.

[92]  Paul J. A. Kenis,et al.  Microfluidic Generation of Gradient Hydrogels to Modulate Hematopoietic Stem Cell Culture Environment , 2014, Advanced healthcare materials.

[93]  Jeffrey M Karp,et al.  Engineering Stem Cell Organoids. , 2016, Cell stem cell.

[94]  D. Sinton,et al.  Evanescent cultivation of photosynthetic bacteria on thin waveguides , 2014 .

[95]  Yana Pigareva,et al.  Design of Cultured Neuron Networks in vitro with Predefined Connectivity Using Asymmetric Microfluidic Channels , 2017, Scientific Reports.

[96]  J. Samitier,et al.  Neuromuscular Activity Induces Paracrine Signaling and Triggers Axonal Regrowth after Injury in Microfluidic Lab-On-Chip Devices , 2020, Cells.

[97]  R. Sandberg,et al.  Gene expression perturbation in vitro--a growing case for three-dimensional (3D) culture systems. , 2005, Seminars in cancer biology.

[98]  Krisna C. Bhargava,et al.  Discrete elements for 3D microfluidics , 2014, Proceedings of the National Academy of Sciences.

[99]  Shoji Takeuchi,et al.  Three-dimensional neuron-muscle constructs with neuromuscular junctions. , 2013, Biomaterials.

[100]  Michael R Hamblin,et al.  Microfluidic systems for stem cell-based neural tissue engineering. , 2016, Lab on a chip.

[101]  John R. Huguenard,et al.  Differentiation and Maturation of Oligodendrocytes in Human Three-Dimensional Neural Cultures , 2018, Nature Neuroscience.

[102]  Eitan Erez Zahavi,et al.  A compartmentalized microfluidic neuromuscular co-culture system reveals spatial aspects of GDNF functions , 2015, Journal of Cell Science.

[103]  S. Leach,et al.  PanIN neuroendocrine cells promote tumorigenesis via neuronal crosstalk. , 2017, Cancer research.

[104]  E. Bertagnolli,et al.  Investigation of neurotrophic factor concentrations with a novel in vitro concept for peripheral nerve regeneration , 2015, Journal of neuroscience research.

[105]  H. Clevers,et al.  Single Lgr5 stem cells build crypt–villus structures in vitro without a mesenchymal niche , 2009, Nature.

[106]  D. Beebe,et al.  PDMS absorption of small molecules and consequences in microfluidic applications. , 2006, Lab on a chip.

[107]  Scott T. Brady,et al.  Local modulation of neurofilament phosphorylation, axonal caliber, and slow axonal transport by myelinating Schwann cells , 1992, Cell.

[108]  R. Mukhopadhyay.  When PDMS isn't the best , 2007 .

[109]  Zhilian Zhou,et al.  The pursuit of a scalable nanofabrication platform for use in material and life science applications. , 2008, Accounts of chemical research.

[110]  Chia-Wen Tsao,et al.  Polymer Microfluidics: Simple, Low-Cost Fabrication Process Bridging Academic Lab Research to Commercialized Production , 2016, Micromachines.

[111]  Conrad D. James,et al.  Patterning Axonal Guidance Molecules Using a Novel Strategy for Microcontact Printing , 2003, Neurochemical Research.

[112]  Ali Khademhosseini,et al.  Microfluidic techniques for development of 3D vascularized tissue. , 2014, Biomaterials.

[113]  J. Salzer,et al.  Myelination , 2016, Current Biology.

[114]  Wytse J. Wadman,et al.  Source (or Part of the following Source): Type Article Title Dual-compartment Neurofluidic System for Electrophysiological Measurements in Physically Segregated and Functionally Connected Neuronal Cell Culture Author(s) Neuroengineering Original Research Article Dual-compartment Neurofluidic System , 2022 .

[115]  F. Pampaloni,et al.  The third dimension bridges the gap between cell culture and live tissue , 2007, Nature Reviews Molecular Cell Biology.

[116]  Noo Li Jeon,et al.  Recreating the perivascular niche ex vivo using a microfluidic approach , 2010, Biotechnology and bioengineering.

[117]  Shuichi Takayama,et al.  Quantitative Analysis of Molecular Absorption into PDMS Microfluidic Channels , 2012, Annals of Biomedical Engineering.

[118]  Fred H. Gage,et al.  In vitro myelin formation using embryonic stem cells , 2015, Development.

[119]  C. Slater.  The Structure of Human Neuromuscular Junctions: Some Unanswered Molecular Questions , 2017, International journal of molecular sciences.

[120]  C. McElroy,et al.  Modeling Human Brain Circuitry Using Pluripotent Stem Cell Platforms , 2019, Front. Pediatr..

[121]  James H Nichols,et al.  Point of care testing. , 2007, Clinics in laboratory medicine.

[122]  David J Beebe,et al.  Micromilling: a method for ultra-rapid prototyping of plastic microfluidic devices. , 2015, Lab on a chip.

[123]  A. Heiligenhaus,et al.  A Therapeutic Antiviral Antibody Inhibits the Anterograde Directed Neuron-to-Cell Spread of Herpes Simplex Virus and Protects against Ocular Disease , 2017, Front. Microbiol..

[124]  Erin K Purcell,et al.  Genetic Modulation at the Neural Microelectrode Interface: Methods and Applications , 2018, Micromachines.

[125]  Daniel R. Berger,et al.  Cell diversity and network dynamics in photosensitive human brain organoids , 2017, Nature.

[126]  Daniele Poli,et al.  Experimental and Computational Methods for the Study of Cerebral Organoids: A Review , 2019, Front. Neurosci..

[127]  Volker Busskamp,et al.  On-demand optogenetic activation of human stem-cell-derived neurons , 2017, Scientific Reports.

[128]  Orly Reiner,et al.  Human Brain Organoids on a Chip Reveal the Physics of Folding , 2018, Nature physics.

[129]  Changkyun Im,et al.  A Low Permeability Microfluidic Blood-Brain Barrier Platform with Direct Contact between Perfusable Vascular Network and Astrocytes , 2017, Scientific Reports.

[130]  Madeline A. Lancaster,et al.  Cerebral organoids model human brain development and microcephaly , 2013, Nature.

[131]  Lance C Kam,et al.  Local presentation of L1 and N‐cadherin in multicomponent, microscale patterns differentially direct neuron function in vitro , 2007, Developmental neurobiology.

[132]  S. Quake,et al.  Monolithic microfabricated valves and pumps by multilayer soft lithography. , 2000, Science.

[133]  Albert Folch,et al.  Mail-order microfluidics: evaluation of stereolithography for the production of microfluidic devices. , 2014, Lab on a chip.

[134]  J. Hickman,et al.  Stem cell derived phenotypic human neuromuscular junction model for dose response evaluation of therapeutics. , 2018, Biomaterials.

[135]  K. Ren,et al.  Materials for microfluidic chip fabrication. , 2013, Accounts of chemical research.

[136]  Nitish V Thakor,et al.  Subcellular electrical stimulation of neurons enhances the myelination of axons by oligodendrocytes , 2017, PloS one.

[137]  M. Lutolf,et al.  Microfluidic patterning of protein gradients on biomimetic hydrogel substrates. , 2014, Methods in cell biology.

[138]  Roger D. Kamm,et al.  Microfluidic device for the formation of optically excitable, three-dimensional, compartmentalized motor units , 2016, Science Advances.

[139]  Ronan M. T. Fleming,et al.  Advantages and challenges of microfluidic cell culture in polydimethylsiloxane devices. , 2015, Biosensors & bioelectronics.

[140]  J. Voldman,et al.  Microfluidic Perfusion for Regulating Diffusible Signaling in Stem Cells , 2011, PloS one.

[141]  A. M. Taylor,et al.  Passive microfluidic chamber for long-term imaging of axon guidance in response to soluble gradients. , 2015, Lab on a chip.

[142]  Kyongbum Lee,et al.  Adipocyte induction of preadipocyte differentiation in a gradient chamber. , 2012, Tissue engineering. Part C, Methods.

[143]  S. Mar,et al.  Axonal damage in leukodystrophies. , 2010, Pediatric neurology.

[144]  Po Ki Yuen,et al.  Multidimensional modular microfluidic system. , 2009, Lab on a chip.

[145]  Labchan Rajbhandari,et al.  Curcumin protects axons from degeneration in the setting of local neuroinflammation , 2014, Experimental Neurology.

[146]  C. Cotman,et al.  A microfluidic culture platform for CNS axonal injury, regeneration and transport , 2005, Nature Methods.

[147]  Julian H. George,et al.  Optogenetic control of iPS cell‐derived neurons in 2D and 3D culture systems using channelrhodopsin‐2 expression driven by the synapsin‐1 and calcium‐calmodulin kinase II promoters , 2019, Journal of tissue engineering and regenerative medicine.

[148]  Anup D. Sharma,et al.  Engineering a 3D functional human peripheral nerve in vitro using the Nerve-on-a-Chip platform , 2019, Scientific Reports.

[149]  Matthew P Taylor,et al.  Alphaherpesvirus axon-to-cell spread involves limited virion transmission , 2012, Proceedings of the National Academy of Sciences.

[150]  Ronan M. T. Fleming,et al.  Derivation of Human Midbrain-Specific Organoids from Neuroepithelial Stem Cells , 2017, Stem cell reports.