论文信息 - FORMULATION AND EVALUATION OF EFFERVESCENT FLOATING TABLETS OF GLIPIZIDE

FORMULATION AND EVALUATION OF EFFERVESCENT FLOATING TABLETS OF GLIPIZIDE

The aim of the present research work was to develop a novel control drug delivery, to improve the solubility of poorly soluble drugs by effervescent technology. Six formulation of effervescent floating tablets of Glipizide were prepared by direct Compression method by using HPMC 100, Eudragit R400, ethyl cellulose as a polymers and sodium bicarbonate, citric acid as an effervescent mixture. They were subjected to Various pre and post compression evaluation parameters and results found to be within I.P limits. From all formulations F4 formulation shows controlled and complete release of drug over a period of 7 hours containing polymer as HPMC 100 and Eudragit Rc100 and shows 98.24% drug release.

[1] Ramandeep Singh Satinderkakar,et al. Gastroretentive drug delivery systems: A review , 2015 .

[2] A. Ojha,et al. Review on Gastro Retentive Drug Delivery System , 2012 .

[3] R. Garg,et al. Progress in Controlled Gastroretentive Delivery Systems , 2008 .

[4] K. Amighi,et al. Development and evaluation of new multiple-unit levodopa sustained-release floating dosage forms. , 2007, International journal of pharmaceutics.

[5] L. Balant,et al. Comparative pharmacokinetic study of a floating multiple-unit capsule, a high-density multiple-unit capsule and an immediate-release tablet containing 25 mg atenolol. , 1998, Pharmaceutica acta Helvetiae.

[6] P. Kothiyal,et al. ON GASTRORETENTIVE DRUG DELIVERY SYSTEM , 2016 .

[7] Paramita Saha,et al. FLOATING DRUG DELIVERY SYSTEM , 2013 .

[8] Biswarup Das,et al. Gastroretentive drug delivery systems: a review , 2010 .

[9] Sanjay S. Patel,et al. Formualtion and evaluation of floating drug delivery system containing clarithromycin for Helicobacter pylori. , 2006, Acta poloniae pharmaceutica.

[10] J. Siepmann,et al. Multiple unit gastroretentive drug delivery systems: a new preparation method for low density microparticles. , 2003, Journal of microencapsulation.