Loss of Acot12 contributes to NAFLD independent of lipolysis of adipose tissue
暂无分享,去创建一个
K. Jang | B. Raught | P. Kim | D. Jun | J. Song | E. Jin | In-Jeoung Baek | Sujeong Park | Chang Yeob Han | C. Han
[1] N. Chandel,et al. Mitochondrial TCA cycle metabolites control physiology and disease , 2020, Nature Communications.
[2] S. Burgess,et al. Impaired ketogenesis and increased acetyl-CoA oxidation promote hyperglycemia in human fatty liver. , 2019, JCI insight.
[3] E. Gratton,et al. StarD5: an ER stress protein regulates plasma membrane and intracellular cholesterol homeostasis[S] , 2019, Journal of Lipid Research.
[4] L. Qin,et al. ACOT12-Dependent Alteration of Acetyl-CoA Drives Hepatocellular Carcinoma Metastasis by Epigenetic Induction of Epithelial-Mesenchymal Transition. , 2019, Cell metabolism.
[5] G. Shulman,et al. Acetyl‐CoA Carboxylase Inhibition Reverses NAFLD and Hepatic Insulin Resistance but Promotes Hypertriglyceridemia in Rodents , 2018, Hepatology.
[6] T. Kodama,et al. Discovery of peroxisome proliferator–activated receptor α (PPARα) activators with a ligand-screening system using a human PPARα-expressing cell line , 2018, The Journal of Biological Chemistry.
[7] H. Shimano,et al. SREBP-regulated lipid metabolism: convergent physiology — divergent pathophysiology , 2017, Nature Reviews Endocrinology.
[8] D. Cohen,et al. Deactivating Fatty Acids: Acyl-CoA Thioesterase-Mediated Control of Lipid Metabolism , 2017, Trends in Endocrinology & Metabolism.
[9] G. Drin,et al. STARD3 mediates endoplasmic reticulum‐to‐endosome cholesterol transport at membrane contact sites , 2017, The EMBO journal.
[10] D. Vance,et al. Fenofibrate, but not ezetimibe, prevents fatty liver disease in mice lacking phosphatidylethanolamine N-methyltransferase[S] , 2017, Journal of Lipid Research.
[11] Jun Wu,et al. Isolation of Mouse Stromal Vascular Cells for Monolayer Culture. , 2017, Methods in molecular biology.
[12] K. Reiss,et al. Regulation of Ketone Body Metabolism and the Role of PPARα , 2016, International journal of molecular sciences.
[13] K. Tsuneyama,et al. High‐fat and high‐cholesterol diet rapidly induces non‐alcoholic steatohepatitis with advanced fibrosis in Sprague–Dawley rats , 2015, Hepatology research : the official journal of the Japan Society of Hepatology.
[14] Philippe Lefebvre,et al. Molecular mechanism of PPARα action and its impact on lipid metabolism, inflammation and fibrosis in non-alcoholic fatty liver disease. , 2015, Journal of hepatology.
[15] M. Trauner,et al. Role of metabolic lipases and lipolytic metabolites in the pathogenesis of NAFLD , 2014, Trends in Endocrinology & Metabolism.
[16] N. Cowieson,et al. Structural Basis for Regulation of the Human Acetyl-CoA Thioesterase 12 and Interactions with the Steroidogenic Acute Regulatory Protein-related Lipid Transfer (START) Domain , 2014, The Journal of Biological Chemistry.
[17] H. Kalbacher,et al. De novo lipogenesis in health and disease. , 2014, Metabolism: clinical and experimental.
[18] N. Møller,et al. Dissecting adipose tissue lipolysis: molecular regulation and implications for metabolic disease. , 2014, Journal of molecular endocrinology.
[19] S. King,et al. STARD6 is expressed in steroidogenic cells of the ovary and can enhance de novo steroidogenesis , 2014, Experimental biology and medicine.
[20] S. D. Rider,et al. Divergence between human and murine peroxisome proliferator-activated receptor alpha ligand specificities[S] , 2013, Journal of Lipid Research.
[21] M. Itoh,et al. Enzymatic and transcriptional regulation of the cytoplasmic acetyl-CoA hydrolase ACOT12[S] , 2013, Journal of Lipid Research.
[22] H. Balderhaar,et al. CORVET and HOPS tethering complexes – coordinators of endosome and lysosome fusion , 2013, Journal of Cell Science.
[23] J. Ellis,et al. Acyl Coenzyme A Thioesterase 7 Regulates Neuronal Fatty Acid Metabolism To Prevent Neurotoxicity , 2013, Molecular and Cellular Biology.
[24] K. Zatloukal,et al. Gene Expression Profiling Unravels Cancer-Related Hepatic Molecular Signatures in Steatohepatitis but Not in Steatosis , 2012, PloS one.
[25] M. Siponen,et al. The emerging role of acyl-CoA thioesterases and acyltransferases in regulating peroxisomal lipid metabolism. , 2012, Biochimica et biophysica acta.
[26] A. Sanyal,et al. Increased hepatic synthesis and dysregulation of cholesterol metabolism is associated with the severity of nonalcoholic fatty liver disease. , 2012, Cell metabolism.
[27] K. Cusi,et al. Role of obesity and lipotoxicity in the development of nonalcoholic steatohepatitis: pathophysiology and clinical implications. , 2012, Gastroenterology.
[28] P. Larsen,et al. Targeted deletion of thioesterase superfamily member 1 promotes energy expenditure and protects against obesity and insulin resistance , 2012, Proceedings of the National Academy of Sciences.
[29] S. Burgess,et al. Excessive hepatic mitochondrial TCA cycle and gluconeogenesis in humans with nonalcoholic fatty liver disease. , 2011, Cell metabolism.
[30] Y. Barak,et al. Role for PPARγ in obesity‐induced hepatic steatosis as determined by hepatocyte‐ and macrophage‐specific conditional knockouts , 2011, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[31] B. Neuschwander‐Tetri. Hepatic lipotoxicity and the pathogenesis of nonalcoholic steatohepatitis: The central role of nontriglyceride fatty acid metabolites , 2010, Hepatology.
[32] Michelle M Wiest,et al. The plasma lipidomic signature of nonalcoholic steatohepatitis , 2009, Hepatology.
[33] Puneet Puri,et al. Nonalcoholic steatohepatitis is associated with altered hepatic MicroRNA expression , 2008, Hepatology.
[34] Z. Huang,et al. Activation of peroxisome proliferator-activated receptor-α in mice induces expression of the hepatic low-density lipoprotein receptor , 2008, British journal of pharmacology.
[35] W. Miller. Mechanism of StAR's regulation of mitochondrial cholesterol import , 2007, Molecular and Cellular Endocrinology.
[36] N. Kaplowitz,et al. Predominant role of sterol response element binding proteins (SREBP) lipogenic pathways in hepatic steatosis in the murine intragastric ethanol feeding model. , 2006, Journal of hepatology.
[37] K. Gumireddy,et al. Free fatty acids produce insulin resistance and activate the proinflammatory nuclear factor-kappaB pathway in rat liver. , 2005, Diabetes.
[38] G. Gibbons,et al. A role for PPARalpha in the control of SREBP activity and lipid synthesis in the liver. , 2005, The Biochemical journal.
[39] J. Jessurun,et al. Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease. , 2005, The Journal of clinical investigation.
[40] J. Schneider,et al. "New" hepatic fat activates PPARalpha to maintain glucose, lipid, and cholesterol homeostasis. , 2005, Cell metabolism.
[41] I. Leclercq,et al. Administration of the potent PPARα agonist, Wy‐14,643, reverses nutritional fibrosis and steatohepatitis in mice , 2004, Hepatology.
[42] I. Leclercq,et al. Central role of PPARα‐dependent hepatic lipid turnover in dietary steatohepatitis in mice , 2003, Hepatology.
[43] F. Foufelle,et al. New perspectives in the regulation of hepatic glycolytic and lipogenic genes by insulin and glucose: a role for the transcription factor sterol regulatory element binding protein-1c. , 2002, The Biochemical journal.
[44] D. Severson,et al. A Role for Peroxisome Proliferator-activated Receptor α (PPARα) in the Control of Cardiac Malonyl-CoA Levels , 2002, The Journal of Biological Chemistry.
[45] S. Colman,et al. BFIT, a unique acyl-CoA thioesterase induced in thermogenic brown adipose tissue: cloning, organization of the human gene and assessment of a potential link to obesity. , 2001, The Biochemical journal.
[46] J. Lehmann,et al. Molecular recognition of fatty acids by peroxisome proliferator-activated receptors. , 2000, Molecular cell.
[47] G. Gores,et al. Ursodeoxycholic acid or clofibrate in the treatment of non‐alcohol‐induced steatohepatitis: A pilot study , 1996, Hepatology.