α2-Fucosyltransferases (FUT1,FUT2, and Sec1)

The human FUT1 and FUT2 α2-fucosyltransferases corresponding to the H and Se enzymes transfer Fuc in α1,2-linkages onto the terminal galactose of lactosamine. Individuals of histoblood-group “O” express the H antigen under control of the FUT1 gene on red cells and vascular endothelium, and the H antigen under control of the FUT2 gene in exocrine secretions.

[1]  Christian Cambillau,et al.  Crystal structures of the bovine β4galactosyltransferase catalytic domain and its complex with uridine diphosphogalactose , 1999, The EMBO journal.

[2]  R. Gale,et al.  Insights into the expression of ABH and Lewis antigens through human bone marrow transplantation. , 1981, American journal of human genetics.

[3]  M. Blaszczyk-Thurin,et al.  Purification of H gene-encoded beta-galactoside alpha 1----2 fucosyltransferase from human serum. , 1990, The Journal of biological chemistry.

[4]  G. Larson,et al.  A Second Nonsecretor Allele of the Blood Group α(1,2)Fucosyl‐transferase Gene (FUT2) , 1996 .

[5]  Y. Koda,et al.  Two Missense Mutations of H Type α(1,2)Fucosyltransferase Gene (FUT1)Responsible for Para‐Bombay Phenotype , 1997, Vox sanguinis.

[6]  M. Kao,et al.  Molecular characterization of secretor type α(1,2)-fucosyltransferase gene deficiency in the Philippine population , 1999, Annals of Hematology.

[7]  W. Morgan,et al.  The detection of a product of the blood group O gene and the relationship of the so-called O-substance to the agglutinates A and B. , 1948, British journal of experimental pathology.

[8]  T. Kumazaki,et al.  Biochemical evidence that secretor gene, Se, is a structural gene encoding a specific fucosyltransferase. , 1984, Proceedings of the National Academy of Sciences of the United States of America.

[9]  N. Raikhel,et al.  Biochemical Characterization and Molecular Cloning of an α-1,2-Fucosyltransferase That Catalyzes the Last Step of Cell Wall Xyloglucan Biosynthesis in Pea* , 2000, The Journal of Biological Chemistry.

[10]  Y. Chen,et al.  Correlation of a missense mutation in the human Secretor alpha 1,2-fucosyltransferase gene with the Lewis(a+b+) phenotype: a potential molecular basis for the weak Secretor allele (Sew). , 1995, The Biochemical journal.

[11]  M. Costache,et al.  Evolution of Fucosyltransferase Genes in Vertebrates* , 1997, The Journal of Biological Chemistry.

[12]  R. Oriol,et al.  Three bovine α2-fucosyltransferase genes encode enzymes that preferentially transfer fucose on Galβ1-3GalNAc acceptor substrates , 2000 .

[13]  G. Lennon,et al.  Molecular cloning of a human genomic region containing the H blood group alpha(1,2)fucosyltransferase gene and two H locus-related DNA restriction fragments. Isolation of a candidate for the human Secretor blood group locus. , 1995, The Journal of biological chemistry.

[14]  P. Levine,et al.  Gene interaction resulting in suppression of blood group substance B. , 1955, Blood.

[15]  R. Sanger,et al.  A "new" blood group character related to the ABO system. , 1952, Lancet.

[16]  J. Lowe,et al.  Molecular basis for H blood group deficiency in Bombay (Oh) and para-Bombay individuals. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[17]  M. Costache,et al.  Molecular Cloning and Expression of a Bovine α(1,3)-Fucosyltransferase Gene Homologous to a Putative Ancestor Gene of the Human FUT3-FUT5-FUT6 Cluster* , 1997, The Journal of Biological Chemistry.

[18]  J. Lowe,et al.  A cloned human DNA restriction fragment determines expression of a GDP-L-fucose: beta-D-galactoside 2-alpha-L-fucosyltransferase in transfected cells. Evidence for isolation and transfer of the human H blood group locus. , 1989, The Journal of biological chemistry.

[19]  R Mollicone,et al.  Divergent evolution of fucosyltransferase genes from vertebrates, invertebrates, and bacteria. , 1999, Glycobiology.

[20]  A. Imberty,et al.  Conserved structural features in eukaryotic and prokaryotic fucosyltransferases. , 1998, Glycobiology.

[21]  Marie Lin,et al.  Heterogeneity of the HumanSecretorα(1,2)Fucosyltransferase Gene among Lewis(a+b−) Non-secretors , 1996 .

[22]  Y. Koda,et al.  Extensive polymorphism of the FUT2 gene in an African (Xhosa) population of South Africa , 1998, Human Genetics.

[23]  Y Koda,et al.  Molecular basis for secretor type alpha(1,2)-fucosyltransferase gene deficiency in a Japanese population: a fusion gene generated by unequal crossover responsible for the enzyme deficiency. , 1996, American journal of human genetics.

[24]  Y. Koda,et al.  Ancient Origin of the Null Allele se428 of the Human ABO-Secretor Locus (FUT2) , 2000, Journal of Molecular Evolution.

[25]  K. Landsteiner,et al.  Ueber Agglutinationserscheinungen normalen menschlichen Blutes , 1901 .

[26]  A. Imberty,et al.  Letters to the Glyco-Forum Sequence alignment and fold recognition of fucosyltransferases , 1996 .

[27]  Marie Lin,et al.  Heterogeneity of the Human H Blood Group α (1,2) Fucosyltransferase Gene among Para‐Bombay Individuals , 1997, Vox sanguinis.

[28]  W. Flegel,et al.  Polymorphism of the h allele and the population frequency of sporadic nonfunctional alleles , 1997, Transfusion.

[29]  M. Kaneko,et al.  Wide variety of point mutations in the H gene of Bombay and para-Bombay individuals that inactivate H enzyme. , 1997, Blood.

[30]  R. Oriol,et al.  Relative positions of two clusters of human alpha-L-fucosyltransferases in 19q (FUT1-FUT2) and 19p (FUT6-FUT3-FUT5) within the microsatellite genetic map of chromosome 19. , 1995, Cytogenetics and cell genetics.

[31]  Point Mutations and Deletion Responsible for the Bombay H null and the Reunion H weak Blood Groups , 1998, Vox sanguinis.

[32]  R. Oriol,et al.  Homozygous expression of a missense mutation at nucleotide 385 in the FUT2 gene associates with the Le(a+b+) partial-secretor phenotype in an Indonesian family. , 1996, Biochemical and Biophysical Research Communications - BBRC.

[33]  J. Lowe,et al.  Molecular cloning, sequence, and expression of a human GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase cDNA that can form the H blood group antigen. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[34]  T. Ando,et al.  Molecular Genetic Analysis of the Human Lewis Histo-blood Group System , 1994, The Journal of Biological Chemistry.

[35]  J. Le Pendu,et al.  The presence of at least two different H-blood-group-related beta-D-gal alpha-2-L-fucosyltransferases in human serum and the genetics of blood group H substances. , 1985, American journal of human genetics.

[36]  N. Raikhel,et al.  Xyloglucan fucosyltransferase, an enzyme involved in plant cell wall biosynthesis. , 1999, Science.

[37]  R. Oriol,et al.  Genetic regulation of the expression of ABH and Lewis antigens in tissues. , 1992, APMIS. Supplementum.

[38]  R. Oriol,et al.  A new genetic model proposing that the Se gene is a structural gene closely linked to the H gene. , 1981, American journal of human genetics.

[39]  R Mollicone,et al.  Evolution of alpha 2-fucosyltransferase genes in primates: relation between an intronic Alu-Y element and red cell expression of ABH antigens. , 2000, Molecular biology and evolution.

[40]  M. Blaszczyk-Thurin,et al.  Purification of the secretor-type beta-galactoside alpha 1----2-fucosyltransferase from human serum. , 1992, The Journal of biological chemistry.

[41]  J. Lowe,et al.  Isolation of a novel human alpha (1,3)fucosyltransferase gene and molecular comparison to the human Lewis blood group alpha (1,3/1,4)fucosyltransferase gene. Syntenic, homologous, nonallelic genes encoding enzymes with distinct acceptor substrate specificities. , 1992, The Journal of biological chemistry.

[42]  C. Chu,et al.  A Newly Identified Nonsecretor Allele of the Human Histo–Blood Group α(1,2)Fucosyltransferase Gene (FUT2) , 1999, Vox Sanguinis.

[43]  P. Toy.  Audit and Education in Transfusion Medicine , 1996, Vox sanguinis.

[44]  G. Lennon,et al.  Sequence and expression of a candidate for the human Secretor blood group alpha(1,2)fucosyltransferase gene (FUT2). Homozygosity for an enzyme-inactivating nonsense mutation commonly correlates with the non-secretor phenotype. , 1995, The Journal of biological chemistry.

[45]  Y. Koda,et al.  Missense mutation of FUT1 and deletion of FUT2 are responsible for Indian Bombay phenotype of ABO blood group system. , 1997, Biochemical and biophysical research communications.

[46]  M. Blajchman,et al.  BACTERIAL CONTAMINATION OF CELLULAR BLOOD COMPONENTS , 1994, Vox sanguinis.

[47]  Y. Koda,et al.  The Fusion Gene at the ABO-Secretor Locus (FUT2): absence in Chinese populations , 1999, Journal of Human Genetics.

[48]  W. Watkins.  Biochemistry and Genetics of the ABO, Lewis, and P blood group systems. , 1980, Advances in human genetics.