Clinical application of image‐based CFD for cerebral aneurysms

During the last decade, the convergence of medical imaging and computational modeling technologies has enabled tremendous progress in the development and application of image-based computational fluid dynamics modeling of patient-specific blood flows. These techniques have been used for studying the basic mechanisms involved in the initiation and progression of vascular diseases, for studying possible ways to improve the diagnosis and evaluation of patients by incorporating hemodynamics information to the anatomical data typically available, and for the development of computational tools that can be used to improve surgical and endovascular treatment planning. However, before these technologies can have a significant impact on the routine clinical practice, it is still necessary to demonstrate the connection between the extra information provided by the models and the natural progression of vascular diseases and the outcome of interventions. This paper summarizes some of our contributions in this direction, focusing in particular on cerebral aneurysms.

[1]  C. Putman,et al.  Flow–area relationship in internal carotid and vertebral arteries , 2008, Physiological measurement.

[2]  Christopher M. Putman,et al.  Analysis of intracranial aneurysm wall motion and its effects on hemodynamic patterns , 2007, SPIE Medical Imaging.

[3]  Joachim Weickert,et al.  Anisotropic diffusion in image processing , 1996 .

[4]  T. N. Stevenson,et al.  Fluid Mechanics , 2021, Nature.

[5]  K. Baráth,et al.  Endovascular treatment of intracranial aneurysms with parent vessel reconstruction using balloon and self expandable stents , 2006, Acta Neurochirurgica.

[6]  Milan Sonka,et al.  "Handbook of Medical Imaging, Volume 2. Medical Image Processing and Analysis " , 2000 .

[7]  Peter L. Choyke,et al.  Isosurfaces as deformable models for magnetic resonance angiography , 2003, IEEE Transactions on Medical Imaging.

[8]  Alejandro F Frangi,et al.  Reproducibility of haemodynamical simulations in a subject-specific stented aneurysm model--a report on the Virtual Intracranial Stenting Challenge 2007. , 2008, Journal of biomechanics.

[9]  Carlos Miranda,et al.  Buenos Aires experience with the Neuroform self-expanding stent for the treatment of intracranial aneurysms. , 2005, Journal of neurosurgery.

[10]  C M Putman,et al.  Hemodynamics in a Lethal Basilar Artery Aneurysm Just before Its Rupture , 2009, American Journal of Neuroradiology.

[11]  C. Putman,et al.  Characterization of cerebral aneurysms for assessing risk of rupture by using patient-specific computational hemodynamics models. , 2005, AJNR. American journal of neuroradiology.

[12]  Alejandro F. Frangi,et al.  Efficient pipeline for image-based patient-specific analysis of cerebral aneurysm hemodynamics: technique and sensitivity , 2005, IEEE Transactions on Medical Imaging.

[13]  Philippe Bijlenga,et al.  Intracranial aneurysm stenting: Follow‐up with MR angiography , 2006, Journal of magnetic resonance imaging : JMRI.

[14]  C M Putman,et al.  Hemodynamics and Bleb Formation in Intracranial Aneurysms , 2010, American Journal of Neuroradiology.

[15]  Alejandro F. Frangi,et al.  Muliscale Vessel Enhancement Filtering , 1998, MICCAI.

[16]  E. Scrivano,et al.  Blood-Flow Characteristics in a Terminal Basilar Tip Aneurysm Prior to Its Fatal Rupture , 2010, American Journal of Neuroradiology.

[17]  Michael P. Szymanski,et al.  A MODEL SYSTEM FOR MAPPING VASCULAR RESPONSES TO COMPLEX HEMODYNAMICS AT ARTERIAL BIFURCATIONS IN VIVO , 2006, Neurosurgery.

[18]  Alejandro F. Frangi,et al.  CFD Analysis Incorporating the Influence of Wall Motion: Application to Intracranial Aneurysms , 2006, MICCAI.

[19]  Michael M. Resch,et al.  Pulsatile non-Newtonian blood flow simulation through a bifurcation with an aneurysm. , 1989, Biorheology.

[20]  M. Negoro,et al.  CT angiography with electrocardiographically gated reconstruction for visualizing pulsation of intracranial aneurysms: identification of aneurysmal protuberance presumably associated with wall thinning. , 2005, AJNR. American journal of neuroradiology.

[21]  Alejandro F Frangi,et al.  Hemodynamics and rupture of terminal cerebral aneurysms. , 2009, Academic radiology.

[22]  F. Meyer,et al.  Pathogenesis, Natural History, and Treatment of Unruptured Intracranial Aneurysms , 2004, Mayo Clinic proceedings.

[23]  T. Papanastasiou Flows of Materials with Yield , 1987 .

[24]  Juan R Cebral,et al.  Patient-specific computational modeling of cerebral aneurysms with multiple avenues of flow from 3D rotational angiography images. , 2006, Academic radiology.

[25]  R. Löhner Regridding Surface Triangulations , 1996 .

[26]  Luca Antiga,et al.  Centerline Computation and Geometric Analysis of Branching Tubular Surfaces with Application to Blood Vessel Modeling , 2003, WSCG.

[27]  Gabriel Taubin,et al.  A signal processing approach to fair surface design , 1995, SIGGRAPH.

[28]  C M Putman,et al.  Hemodynamic Patterns of Anterior Communicating Artery Aneurysms: A Possible Association with Rupture , 2009, American Journal of Neuroradiology.

[29]  Thomas J. R. Hughes,et al.  Finite element modeling of blood flow in arteries , 1998 .

[30]  Rainald Löhner,et al.  Deflated preconditioned conjugate gradient solvers for the Pressure-Poisson equation , 2008, J. Comput. Phys..

[31]  Rainald Löhner,et al.  Automatic unstructured grid generators , 1997 .

[32]  Rainald Löhner,et al.  Efficient simulation of blood flow past complex endovascular devices using an adaptive embedding technique , 2005, IEEE Transactions on Medical Imaging.

[33]  Rainald Löhner,et al.  Computational fluid dynamics of stented intracranial aneurysms using adaptive embedded unstructured grids , 2008 .

[34]  Christopher M. Putman,et al.  Hemodynamics before and after bleb formation in cerebral aneurysms , 2007, SPIE Medical Imaging.

[35]  Rainald Löhner,et al.  From medical images to anatomically accurate finite element grids , 2001 .

[36]  Christopher M. Putman,et al.  Estimation of wall motion in intracranial aneurysms and its effects on hemodynamic patterns , 2006 .

[37]  Fernando Mut,et al.  Simulation of Stent Deployment in Patient-Specific Cerebral Aneurysm Models for Their Hemodynamics Analysis , 2008 .

[38]  B. Weir Unruptured intracranial aneurysms: a review. , 2002, Journal of neurosurgery.

[39]  T F Sherman,et al.  On connecting large vessels to small. The meaning of Murray's law , 1981, The Journal of general physiology.