A model for UV-induction of skin cancer

The cellular and molecular events that contribute to the development of UV-induced skin cancer is a complex process involving at least two distinct pathways that interact or converge to cause skin cancer (Figure ​(Figure1).1). One pathway involves the action of UV on target cells (keratinocytes) for neoplastic transformation, and the other involves the effects of UV on the host's immune system [1]. There is evidence to indicate that UV-induced DNA damage plays an important role in both pathways.

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