Chapter 10 – Information Technology

Publisher Summary Though related to clinical information technology, clinical research information technology poses its own set of data management challenges that are unique. The problems of using clinical data repositories as a data source for research are examined in this chapter, as are the advantages of using pre-research clinical registries. Clinical data warehousing principles are described, including detail on database design, the organization of metadata, and work processes. Techniques for applying information technology to the vexing problem of study participant recruitment are discussed. A review of the principles of data collection for clinical research covers issues of automation, data validity and the integration of research data collection with clinical care. The discussion also touches briefly on data standards in clinical research, clinical trial management systems, publicly available biomedical literature databases, and emerging approaches to data integration using new Web technologies.

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