Analysis of Mammalian Carboxylesterase Inhibition by Trifluoromethylketone-Containing Compounds
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Bruce D. Hammock | Matthew R. Redinbo | Paul D. Jones | M. Redinbo | P. Potter | C. Wheelock | B. Hammock | R. M. Wadkins | Craig E. Wheelock | Lyudmila Tsurkan | Randy M. Wadkins | Philip M. Potter | Janice L. Hyatt | Carol C. Edwards | C. Edwards | L. Tsurkan | J. Hyatt
[1] C. Morton,et al. Isolation and partial characterization of a cDNA encoding a rabbit liver carboxylesterase that activates the prodrug irinotecan (CPT-11). , 1998, Cancer research.
[2] M. Redinbo,et al. Mammalian carboxylesterases: from drug targets to protein therapeutics. , 2005, Drug discovery today.
[3] J. L. Webb. General principles of inhibition , 1963 .
[4] C. Wheelock,et al. Overview of Carboxylesterases and Their Role in the Metabolism of Insecticides , 2005 .
[5] G. Rosell,et al. New trifluoromethyl ketones as potent inhibitors of esterases: 19F NMR spectroscopy of transition state analog complexes and structure-activity relationships. , 1996, Biochemical and biophysical research communications.
[6] R. Roe,et al. Inhibition of insect juvenile hormone esterase by α,β-unsaturated and α-acetylenic trifluoromethyl ketones , 1989 .
[7] B. Hammock,et al. Substituted thiotrifluoropropanones as potent selective inhibitors of juvenile hormone esterase , 1984 .
[8] D. V. Von Hoff,et al. Water soluble 20(S)-glycinate esters of 10,11-methylenedioxycamptothecins are highly active against human breast cancer xenografts. , 1999, Cancer research.
[9] John Leyden. Webb,et al. Enzyme and metabolic inhibitors , 1963 .
[10] E A Merritt,et al. Raster3D: photorealistic molecular graphics. , 1997, Methods in enzymology.
[11] Araz Jakalian,et al. Fast, efficient generation of high‐quality atomic charges. AM1‐BCC model: I. Method , 2000 .
[12] C. Wheelock,et al. Synthesis of new carboxylesterase inhibitors and evaluation of potency and water solubility. , 2001, Chemical research in toxicology.
[13] Max Dobler,et al. Multidimensional QSAR: Moving from three‐ to five‐dimensional concepts , 2002 .
[14] J R Cashman,et al. Pharmacokinetics and molecular detoxication. , 1996, Environmental health perspectives.
[15] D. M. Graves,et al. A novel geminal diol as a highly specific and stable in vivo inhibitor of insect juvenile hormone esterase , 1997 .
[16] P. Beroza,et al. Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases. , 2005, Journal of medicinal chemistry.
[17] P. Kraulis. A program to produce both detailed and schematic plots of protein structures , 1991 .
[18] T. Lundstedt,et al. Experimental design and optimization , 1998 .
[19] M. Redinbo,et al. Structural insights into CPT-11 activation by mammalian carboxylesterases , 2002, Nature Structural Biology.
[20] Sompop Bencharit,et al. Structural insights into drug processing by human carboxylesterase 1: tamoxifen, mevastatin, and inhibition by benzil. , 2005, Journal of molecular biology.
[21] C. Morton,et al. Comparison of Escherichia coli, Saccharomyces cerevisiae, Pichia pastoris, Spodoptera frugiperda, and COS7 cells for recombinant gene expression , 2000, Molecular biotechnology.
[22] P. Kuhn,et al. Crystal structure of human carboxylesterase 1 complexed with the Alzheimer's drug tacrine: from binding promiscuity to selective inhibition. , 2003, Chemistry & biology.
[23] M. Akamatsu,et al. Use of classical and 3-D QSAR to examine the hydration state of juvenile hormone esterase inhibitors. , 2003, Bioorganic & medicinal chemistry.
[24] M. Rottenberg,et al. Fluorinated aldehydes and ketones acting as quasi-substrate inhibitors of acetylcholinesterase. , 1979, Biochimica et biophysica acta.
[25] Christopher I. Bayly,et al. Fast, efficient generation of high‐quality atomic charges. AM1‐BCC model: II. Parameterization and validation , 2002, J. Comput. Chem..
[26] K. D. Wing,et al. Trifluoromethylketones as possible transition state analog inhibitors of juvenile hormone esterase , 1982 .
[27] P. Potter,et al. Hydrolytic metabolism of pyrethroids by human and other mammalian carboxylesterases. , 2006, Biochemical pharmacology.
[28] C. Pratt,et al. St. Jude Children's Research Hospital. , 1997, Pediatric hematology and oncology.
[29] A. Vedani,et al. Combining protein modeling and 6D-QSAR. Simulating the binding of structurally diverse ligands to the estrogen receptor. , 2005, Journal of medicinal chemistry.
[30] H. Chapman,et al. A serine esterase released by human alveolar macrophages is closely related to liver microsomal carboxylesterases. , 1991, The Journal of biological chemistry.
[31] C. Walsh,et al. The behavior and significance of slow-binding enzyme inhibitors. , 2006, Advances in enzymology and related areas of molecular biology.
[32] Sami Ahmad,et al. Nonoxidative enzymes in the metabolism of insecticides. , 1976, Annals of clinical biochemistry.
[33] A. D. Jones,et al. Use of ab initio calculations to predict the biological potency of carboxylesterase inhibitors. , 2002, Journal of medicinal chemistry.
[34] I. Silman,et al. Microtiter assay for acetylcholinesterase. , 1987, Analytical biochemistry.
[35] Max Dobler,et al. 5D-QSAR: the key for simulating induced fit? , 2002, Journal of medicinal chemistry.
[36] T. Langmann,et al. Molecular cloning and characterization of a novel putative carboxylesterase, present in human intestine and liver. , 1997, Biochemical and biophysical research communications.
[37] James J. P. Stewart,et al. MOPAC: A semiempirical molecular orbital program , 1990, J. Comput. Aided Mol. Des..
[38] B. Hammock,et al. Substituted trifluoroketones as potent, selective inhibitors of mammalian carboxylesterases. , 1987, Biochemical pharmacology.
[39] C. Morton,et al. The anticancer prodrug CPT-11 is a potent inhibitor of acetylcholinesterase but is rapidly catalyzed to SN-38 by butyrylcholinesterase. , 1999, Cancer research.
[40] W. Draber,et al. Rational Approaches to Structure, Activity, and Ecotoxicology of Agrochemicals , 1992 .
[41] P. Beroza,et al. Discovery of novel selective inhibitors of human intestinal carboxylesterase for the amelioration of irinotecan-induced diarrhea: synthesis, quantitative structure-activity relationship analysis, and biological activity. , 2004, Molecular pharmacology.
[42] M. Zeller,et al. Inhibition of carboxylesterases by benzil (diphenylethane-1,2-dione) and heterocyclic analogues is dependent upon the aromaticity of the ring and the flexibility of the dione moiety. , 2005, Journal of medicinal chemistry.