Widespread epileptic networks in focal epilepsies: EEG‐fMRI study

Purpose:  To assess the extent of brain involvement during focal epileptic activity, we studied patterns of cortical and subcortical metabolic changes coinciding with interictal epileptic discharges (IEDs) using group analysis of simultaneous electroencephalography and functional magnetic resonance imaging (EEG‐fMRI) scans in patients with focal epilepsy.

[1]  W. Oertel,et al.  Motor cortex excitability in focal epilepsies not including the primary motor area--a TMS study. , 2005, Brain : a journal of neurology.

[2]  S. Spencer,et al.  Localization of extratemporal epileptic foci during ictal single photon emission computed tomography , 1992, Annals of neurology.

[3]  M. Fox,et al.  Noninvasive functional and structural connectivity mapping of the human thalamocortical system. , 2010, Cerebral cortex.

[4]  Luis Concha,et al.  Bilateral White Matter Diffusion Changes Persist after Epilepsy Surgery , 2007, Epilepsia.

[5]  Leonardo Bonilha,et al.  NETWORK ATROPHY IN TEMPORAL LOBE EPILEPSY: A VOXEL-BASED MORPHOMETRY STUDY , 2009, Neurology.

[6]  Colin Studholme,et al.  Positive and negative network correlations in temporal lobe epilepsy. , 2004, Cerebral cortex.

[7]  L. Lemieux,et al.  Neuronal networks in children with continuous spikes and waves during slow sleep. , 2010, Brain : a journal of neurology.

[8]  J. Gotman,et al.  Quality of EEG in simultaneous EEG-fMRI for epilepsy , 2003, Clinical Neurophysiology.

[9]  D. Perani,et al.  Interhemispheric transmission of visuomotor information in humans: fMRI evidence. , 2002, Journal of neurophysiology.

[10]  M. Walker,et al.  EEG correlated functional MRI and postoperative outcome in focal epilepsy , 2010, Journal of Neurology, Neurosurgery & Psychiatry.

[11]  Thomas E. Nichols,et al.  Non-white noise in fMRI: Does modelling have an impact? , 2006, NeuroImage.

[12]  A. Kleinschmidt,et al.  Temporal lobe interictal epileptic discharges affect cerebral activity in “default mode” brain regions , 2006, Human brain mapping.

[13]  Jerome Engel,et al.  Role of the Frontal Lobes in the Propagation of Mesial Temporal Lobe Seizures , 1991, Epilepsia.

[14]  J. Gotman Epileptic networks studied with EEG‐fMRI , 2008, Epilepsia.

[15]  Ulrich Stephani,et al.  EEG‐fMRI reveals activation of brainstem and thalamus in patients with Lennox‐Gastaut syndrome , 2011, Epilepsia.

[16]  F. Leijten,et al.  EEG-fMRI in the preoperative work-up for epilepsy surgery. , 2007, Brain : a journal of neurology.

[17]  L Lemieux,et al.  Converging PET and fMRI evidence for a common area involved in human focal epilepsies , 2011, Neurology.

[18]  C D Binnie,et al.  Selective cognitive impairment during focal and generalized epileptiform EEG activity. , 1984, Brain : a journal of neurology.

[19]  L S Adelman,et al.  Location of human pyramidal tract in the internal capsule , 1975, Neurology.

[20]  E. Dietrichs Divergent axon collaterals to cerebellum and amygdala from neurons in the parabrachial nucleus, the nucleus locus coeruleus and some adjacent nuclei , 1985, Anatomy and Embryology.

[21]  Jean Gotman,et al.  EEG‐fMRI of focal epileptic spikes: Analysis with multiple haemodynamic functions and comparison with gadolinium‐enhanced MR angiograms , 2004, Human brain mapping.

[22]  J. Gotman,et al.  Generalized epileptic discharges show thalamocortical activation and suspension of the default state of the brain. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[23]  Devin K. Binder,et al.  Altered white matter integrity in temporal lobe epilepsy: Association with cognitive and clinical profiles , 2010, Epilepsia.

[24]  Timothy Edward John Behrens,et al.  Non-invasive mapping of connections between human thalamus and cortex using diffusion imaging , 2003, Nature Neuroscience.

[25]  Jean Gotman,et al.  Structures involved at the time of temporal lobe spikes revealed by interindividual group analysis of EEG/fMRI data , 2009, Epilepsia.

[26]  D. Collins,et al.  Automatic 3D Intersubject Registration of MR Volumetric Data in Standardized Talairach Space , 1994, Journal of computer assisted tomography.

[27]  A. Brodal Cerebrocerebellar pathways. Anatomical data and some functional implications. , 1972, Acta neurologica Scandinavica. Supplementum.

[28]  T. Shiga,et al.  Thalamic asymmetry on interictal SPECT in patients with frontal lobe epilepsy , 2001, Nuclear medicine communications.

[29]  Xiang-Qing Wang,et al.  Changes in extrafrontal integrity and cognition in frontal lobe epilepsy: A diffusion tensor imaging study , 2011, Epilepsy & Behavior.

[30]  I. Scheffer,et al.  The core network in absence epilepsy , 2010, Neurology.

[31]  Neda Bernasconi,et al.  MRI volumetry of the thalamus in temporal, extratemporal, and idiopathic generalized epilepsy , 2003, Neurology.

[32]  D. Louis Collins,et al.  Whole-brain voxel-based statistical analysis of gray matter and white matter in temporal lobe epilepsy , 2004, NeuroImage.

[33]  D. Hadley,et al.  Ictal regional cerebral blood flow in frontal lobe seizures , 1997, Seizure.

[34]  Sina Zarei Mahmoodabadi,et al.  Widespread cortical thinning in children with frontal lobe epilepsy , 2011, Epilepsia.

[35]  Alan C. Evans,et al.  A General Statistical Analysis for fMRI Data , 2000, NeuroImage.

[36]  R. Heath,et al.  Ascending projections of the cerebellar fastigial nucleus to the hippocampus, amygdala, and other temporal lobe sites: evoked potential and histological studies in monkeys and cats. , 1974, Experimental neurology.

[37]  Robert Turner,et al.  A Method for Removing Imaging Artifact from Continuous EEG Recorded during Functional MRI , 2000, NeuroImage.

[38]  C. Binnie,et al.  Cognitive impairment during epileptiform discharges: is it ever justifiable to treat the EEG? , 2003, The Lancet Neurology.

[39]  Erin L. Mazerolle,et al.  Investigation of fMRI activation in the internal capsule , 2011, BMC Neuroscience.

[40]  Luis Concha,et al.  Bilateral limbic diffusion abnormalities in unilateral temporal lobe epilepsy , 2005, Annals of neurology.

[41]  J. Zentner,et al.  Surgical treatment of epilepsies. , 2002, Acta neurochirurgica. Supplement.

[42]  O. Muzik,et al.  Metabolic Changes of Subcortical Structures in Intractable Focal Epilepsy , 2004, Epilepsia.

[43]  R. Buckner,et al.  Functional-Anatomic Fractionation of the Brain's Default Network , 2010, Neuron.

[44]  Steven D Beyea,et al.  Detecting functional magnetic resonance imaging activation in white matter: Interhemispheric transfer across the corpus callosum , 2008, BMC Neuroscience.