Insulin Effectiveness, a Measure Consisting of Insulin Sensitivity, 1 Secretion, and Clearance, Captures Differences Between Diabetic and 2 Nondiabetic States 3

[1]  K. Kajiwara,et al.  Potential Identification of Type 2 Diabetes with Elevated Insulin Clearance , 2022, NEJM Evidence.

[2]  C. Cobelli,et al.  Minimal and Maximal Models to Quantitate Glucose Metabolism: Tools to Measure, to Simulate and to Run in Silico Clinical Trials , 2021, Journal of diabetes science and technology.

[3]  A. Tura,et al.  Insulin resistance in congenital adrenal hyperplasia is compensated for by reduced insulin clearance. , 2021, The Journal of clinical endocrinology and metabolism.

[4]  Roberto Bizzotto,et al.  Mathematical Modeling for the Physiological and Clinical Investigation of Glucose Homeostasis and Diabetes , 2020, Frontiers in Physiology.

[5]  R. DeFronzo,et al.  Adaptation of Insulin Clearance to Metabolic Demand Is a Key Determinant of Glucose Tolerance , 2020, Diabetes.

[6]  R. Bergman,et al.  The Measurement of Insulin Clearance , 2020, Diabetes Care.

[7]  G. Charles-Edwards,et al.  Insulin clearance as the major player in the hyperinsulinaemia of black African men without diabetes , 2020, Diabetes, obesity & metabolism.

[8]  A. De Gaetano,et al.  A novel fast-slow model of diabetes progression: Insights into mechanisms of response to the interventions in the Diabetes Prevention Program , 2019, PloS one.

[9]  R. Bergman,et al.  Hypothesis: Role of Reduced Hepatic Insulin Clearance in the Pathogenesis of Type 2 Diabetes , 2019, Diabetes.

[10]  S. Caprio,et al.  Lower Insulin Clearance Parallels a Reduced Insulin Sensitivity in Obese Youths and Is Associated With a Decline in β-Cell Function Over Time , 2019, Diabetes.

[11]  A. Sherman,et al.  Type 2 Diabetes: One Disease, Many Pathways , 2019, bioRxiv.

[12]  Shinya Kuroda,et al.  Increase in hepatic and decrease in peripheral insulin clearance characterize abnormal temporal patterns of serum insulin in diabetic subjects , 2018, npj Systems Biology and Applications.

[13]  U. Alon,et al.  Dynamical compensation in physiological circuits , 2016, Molecular systems biology.

[14]  G. Reaven,et al.  Insulin clearance: an underappreciated modulator of plasma insulin concentration , 2016, Journal of Investigative Medicine.

[15]  R. Unger,et al.  Glucagon is the key factor in the development of diabetes , 2016, Diabetologia.

[16]  A. Basu,et al.  The Forgotten Role of Glucose Effectiveness in the Regulation of Glucose Tolerance , 2015, Current Diabetes Reports.

[17]  R. DeFronzo,et al.  The disposition index does not reflect β-cell function in IGT subjects treated with pioglitazone. , 2014, The Journal of clinical endocrinology and metabolism.

[18]  S. Seino,et al.  Postprandial serum C-peptide to plasma glucose concentration ratio correlates with oral glucose tolerance test- and glucose clamp-based disposition indexes. , 2013, Metabolism: clinical and experimental.

[19]  Claudio Cobelli,et al.  The disposition index: from individual to population approach. , 2012, American journal of physiology. Endocrinology and metabolism.

[20]  Sara Taskinen,et al.  smatr 3– an R package for estimation and inference about allometric lines , 2012 .

[21]  J. Rotter,et al.  Fasting insulin reflects heterogeneous physiological processes: role of insulin clearance. , 2011, American journal of physiology. Endocrinology and metabolism.

[22]  Greg Gibson,et al.  Decanalization and the origin of complex disease , 2009, Nature Reviews Genetics.

[23]  Claudio Cobelli,et al.  Assessment of beta-cell function in humans, simultaneously with insulin sensitivity and hepatic extraction, from intravenous and oral glucose tests. , 2007, American journal of physiology. Endocrinology and metabolism.

[24]  R. Bergman,et al.  Beta-cell "rest" accompanies reduced first-pass hepatic insulin extraction in the insulin-resistant, fat-fed canine model. , 2007, American journal of physiology. Endocrinology and metabolism.

[25]  R. Bergman,et al.  Longitudinal Compensation for Fat-induced Insulin Resistance Includes Reduced Insulin Clearance and Enhanced ␤-cell Response Research Design and Methods , 2022 .

[26]  R. Miura,et al.  A Model of β -Cell Mass, Insulin, and Glucose Kinetics: Pathways to Diabetes , 2000 .

[27]  K. Polonsky,et al.  Alterations in the glucose-stimulated insulin secretory dose-response curve and in insulin clearance in nondiabetic insulin-resistant individuals. , 1997, The Journal of clinical endocrinology and metabolism.

[28]  R. Bergman,et al.  Short-term hyperglycemia and hyperinsulinemia improve insulin action but do not alter glucose action in normal humans. , 1992, The American journal of physiology.

[29]  R. Bergman,et al.  Relationship of insulin clearance and secretion to insulin sensitivity in non‐diabetic Mexican Americans , 1992, European journal of clinical investigation.

[30]  R. DeFronzo,et al.  Glucose clamp technique: a method for quantifying insulin secretion and resistance. , 1979, The American journal of physiology.

[31]  SoJung Lee,et al.  Measuring b-Cell Function Relative to Insulin Sensitivity in Youth Does the hyperglycemic clamp suffice? , 2012 .

[32]  Michael Stumvoll,et al.  Glucose allostasis. , 2003, Diabetes.