Discovery of N-(2-chloro-5-(3-(pyridin-4-yl)-1H-pyrazolo[3,4-b]pyridin-5-yl)pyridin-3-yl)-4-fluorobenzenesulfonamide (FD274) as a highly potent PI3K/mTOR dual inhibitor for the treatment of acute myeloid leukemia.
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Yaming Zhou | Jianxin Wang | Xiaofeng Liu | Yun Ling | Mingli Deng | Yu Jia | Yi Chen | Yongtai Yang | Tianze Wu | Chen‐Yui Yang | Yu-Jun Gao