The (cid:1) 256T (cid:2) C Polymorphism in the Apolipoprotein A-II Gene Promoter Is Associated with Body Mass Index and Food Intake in the Genetics of Lipid Lowering Drugs and Diet Network Study

Background: Apolipoprotein A-II (APOA2) plays an ambiguous role in lipid metabolism, obesity, and atherosclerosis. Methods: We studied the association between a functional APOA2 promoter polymorphism ( (cid:1) 265T > C) and plasma lipids (fasting and postprandial), anthropometric variables, and food intake in 514 men and 564 women who participated in the Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) study. We obtained fasting and postprandial (after consuming a high-fat meal) measures. We measured lipoprotein particle concentrations by proton nuclear magnetic resonance spectroscopy and estimated dietary intake by use of a validated questionnaire. Results: We observed recessive effects for this polymorphism that were homogeneous by sex. Individuals homozygous for the (cid:1) 265C allele had statistically higher body mass index (BMI) than did carriers of the T allele. Consistently, after multivariate adjustment, the odds ratio for obesity in CC individuals compared with T allele carriers was 1.70 (95% CI 1.02–2.80, P (cid:2) 0.039). Interestingly, total energy intake in CC individuals was statistically higher [mean (SE) 9371 (497) vs 8456 (413) kJ/d, P (cid:2) 0.005] than in T allele carriers. Likewise, total fat and protein intakes (expressed in grams per day) were statistically

[1]  Melinda E. Lull,et al.  Apo-AII is an elevated biomarker of chronic non-human primate ethanol self-administration. , 2006, Alcohol and alcoholism.

[2]  Claude Bouchard,et al.  The Human Obesity Gene Map: The 2005 Update , 2006, Obesity.

[3]  N. Cook,et al.  Non-HDL cholesterol, apolipoproteins A-I and B100, standard lipid measures, lipid ratios, and CRP as risk factors for cardiovascular disease in women. , 2005, JAMA.

[4]  Jan Karlsson,et al.  Genetic and environmental influences on eating behavior: the Swedish Young Male Twins Study. , 2005, The American journal of clinical nutrition.

[5]  J. Lovejoy,et al.  Apolipoprotein A-II polymorphism and visceral adiposity in African-American and white women. , 2005, Obesity research.

[6]  William E Grizzle,et al.  Serum levels of an isoform of apolipoprotein A-II as a potential marker for prostate cancer. , 2005, Clinical cancer research : an official journal of the American Association for Cancer Research.

[7]  Frédéric Fumeron,et al.  Polymorphism of the 5-HT2A receptor gene and food intakes in children and adolescents: the Stanislas Family Study. , 2005, The American journal of clinical nutrition.

[8]  R. Jandacek,et al.  Diurnal changes in intestinal apolipoprotein A-IV and its relation to food intake and corticosterone in rats. , 2005, American journal of physiology. Gastrointestinal and liver physiology.

[9]  Alberto Riva,et al.  MAPPER: a search engine for the computational identification of putative transcription factor binding sites in multiple genomes , 2005, BMC Bioinformatics.

[10]  P. Tso,et al.  Apolipoprotein A-IV, food intake, and obesity , 2004, Physiology & Behavior.

[11]  D. Arnett,et al.  Comparison of ultracentrifugation and nuclear magnetic resonance spectroscopy in the quantification of triglyceride-rich lipoproteins after an oral fat load. , 2004, Clinical chemistry.

[12]  F. Blanco-Vaca,et al.  Apolipoprotein A-II, genetic variation on chromosome 1q21-q24, and disease susceptibility , 2004, Current opinion in lipidology.

[13]  C. Bouchard,et al.  A genome-wide linkage scan for dietary energy and nutrient intakes: the Health, Risk Factors, Exercise Training, and Genetics (HERITAGE) Family Study. , 2004, The American journal of clinical nutrition.

[14]  C. Shelley,et al.  A DNA polymorphism of the apoprotein AII gene in hypertriglyceridaemia , 1986, Human Genetics.

[15]  J. Chambaz,et al.  Apolipoprotein A-II: beyond genetic associations with lipid disorders and insulin resistance , 2003, Current opinion in lipidology.

[16]  M. Emi,et al.  Interaction between the LDL-receptor gene bearing a novel mutation and a variant in the apolipoprotein A-II promoter: molecular study in a 1135-member familial hypercholesterolemia kindred , 2002, Journal of Human Genetics.

[17]  E. Boerwinkle,et al.  Sequence polymorphism at the human apolipoprotein AII gene (APOA2): unexpected deficit of variation in an African-American sample , 2002, Human Genetics.

[18]  J. Fruchart,et al.  Apolipoprotein A-II, HDL metabolism and atherosclerosis. , 2002, Atherosclerosis.

[19]  J. Jobe,et al.  Cognitive research enhances accuracy of food frequency questionnaire reports: results of an experimental validation study. , 2002, Journal of the American Dietetic Association.

[20]  J. Otvos,et al.  Measurement of lipoprotein subclass profiles by nuclear magnetic resonance spectroscopy. , 2002, Clinical laboratory.

[21]  D. Midthune,et al.  Comparative validation of the Block, Willett, and National Cancer Institute food frequency questionnaires : the Eating at America's Table Study. , 2001, American journal of epidemiology.

[22]  F. Blanco-Vaca,et al.  Role of apoA-II in lipid metabolism and atherosclerosis: advances in the study of an enigmatic protein. , 2001, Journal of lipid research.

[23]  A. Hamsten,et al.  Human Evidence That the Apolipoprotein A-II Gene Is Implicated in Visceral Fat Accumulation and Metabolism of Triglyceride-Rich Lipoproteins , 2001, Circulation.

[24]  A. Lusis,et al.  Studies with apolipoprotein A-II transgenic mice indicate a role for HDLs in adiposity and insulin resistance. , 2001, Diabetes.

[25]  G. Siest,et al.  Association of a functional 5-HT transporter gene polymorphism with anorexia nervosa and food intake , 2001, Molecular Psychiatry.

[26]  G. Luc,et al.  Decreased Susceptibility to Diet-Induced Atherosclerosis in Human Apolipoprotein A-II Transgenic Mice , 2000, Arteriosclerosis, thrombosis, and vascular biology.

[27]  G Siest,et al.  5-HT2A receptor gene polymorphism is associated with food and alcohol intake in obese people , 2000, International Journal of Obesity.

[28]  T. Bouchard,et al.  Genetic and environmental influences on self-reported diet: a reared-apart twin study , 1998, Physiology & Behavior.

[29]  J. Ordóñez‐Llanos,et al.  Human apolipoprotein A-II is a pro-atherogenic molecule when it is expressed in transgenic mice at a level similar to that in humans: evidence of a potentially relevant species-specific interaction with diet. , 1998, Journal of lipid research.

[30]  A. Lusis,et al.  Overexpression of apolipoprotein AII in transgenic mice converts high density lipoproteins to proinflammatory particles. , 1997, The Journal of clinical investigation.

[31]  C. Bouchard,et al.  The MspI polymorphism of the apolipoprotein A-II gene as a modulator of the dyslipidemic state found in visceral obesity. , 1997, Atherosclerosis.

[32]  D C Rao,et al.  NHLBI Family Heart Study: objectives and design. , 1996, American journal of epidemiology.

[33]  A. Lusis,et al.  Apolipoprotein A-II: a protein in search of a function. , 1994, The Canadian journal of cardiology.

[34]  A. Daluiski,et al.  Evidence for linkage of the apolipoprotein A-II locus to plasma apolipoprotein A-II and free fatty acid levels in mice and humans. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[35]  J. K. Dunn,et al.  Relation of triglyceride metabolism and coronary artery disease. Studies in the postprandial state. , 1992, Arteriosclerosis and thrombosis : a journal of vascular biology.

[36]  E. Rubin,et al.  Expression of human apolipoprotein A-II and its effect on high density lipoproteins in transgenic mice. , 1992, The Journal of biological chemistry.

[37]  J. Cardelli,et al.  Increased apolipoprotein A-IV in rat mesenteric lymph after lipid meal acts as a physiological signal for satiation. , 1992, The American journal of physiology.

[38]  J. Buring,et al.  Decreased HDL2 and HDL3 Cholesterol, Apo A‐I and Apo A‐II, and Increased Risk of Myocardial Infarction , 1992, Circulation.

[39]  J. Scott,et al.  HIGH-DENSITY LIPOPROTEIN COMPOSITION IS ALTERED BY A COMMON DNA POLYMORPHISM ADJACENT TO APOPROTEIN AII GENE IN MAN , 1985, The Lancet.

[40]  L Wilhelmsen,et al.  Multivariate Analyses of Serum Apolipoproteins and Risk Factors in Relation to Acute Myocardial Infarction , 1981, Arteriosclerosis.