Circulating Oxidized Low-Density Lipoprotein and Common Carotid Artery Intima-Media Thickness in a Random Sample of Middle-Aged Men

Circulating oxidized low-density lipoprotein (oxLDL) has been suggested to play an important role in atherosclerosis development. According to previous observations, oxLDL correlates with clinically manifest coronary and carotid artery disease. We investigated the association between the oxLDL concentration measured directly in plasma and common carotid artery intima-media thickness (IMT) in a population-based, case-control study in middle-aged men from Southern Finland. oxLDL was determined in 214 men by a commercially available sandwich ELISA test (Mercodia). Carotid artery IMT was measured at 12 standardized segments by B-mode ultrasonography (at the near and far wall of the left and right common carotid arteries, bifurcations and internal carotid arteries), and the overall mean maximum IMT (MMaxIMT) was calculated. The MMaxIMT of the carotid arteries was significantly associated with circulating oxLDL (rs = 0.16, p = 0.018). In a stepwise multiple regression model with MMaxIMT as dependent variable and systolic blood pressure, smoking, oxLDL, HDL cholesterol and apolipoprotein B as covariates, systolic blood pressure (β = 0.22, p < 0.001), oxLDL (β = 0.15, p = 0.022) and smoking (β = 0.17, p = 0.014) showed an independent association with IMT (R2 = 0.10, p < 0.001). Our results show that oxLDL measured directly from plasma is independently associated with subclinical carotid artery atherosclerosis in middle-aged men.

[1]  T. Lehtimäki,et al.  Oxidized LDL autoantibodies are related to apolipoprotein E phenotype, independently of postprandial change in plasma triglycerides and LDL size, among patients with angiographically verified coronary artery disease and healthy controls. , 2003, Journal of biomedical science.

[2]  H. Horiguchi,et al.  Oxidized LDL in Carotid Plaques and Plasma Associates With Plaque Instability , 2002, Arteriosclerosis, thrombosis, and vascular biology.

[3]  S. Azen,et al.  Alpha-Tocopherol Supplementation in Healthy Individuals Reduces Low-Density Lipoprotein Oxidation but Not Atherosclerosis: The Vitamin E Atherosclerosis Prevention Study (VEAPS) , 2002, Circulation.

[4]  B. Fagerberg,et al.  Circulating Oxidized LDL Is Associated With Subclinical Atherosclerosis Development and Inflammatory Cytokines (AIR Study) , 2002, Arteriosclerosis, thrombosis, and vascular biology.

[5]  F. Van de Werf,et al.  Circulating Oxidized LDL Is a Useful Marker for Identifying Patients With Coronary Artery Disease , 2001, Arteriosclerosis, thrombosis, and vascular biology.

[6]  J. Viikari,et al.  Oxidized LDL and thickness of carotid intima-media are associated with coronary atherosclerosis in middle-aged men: lower levels of oxidized LDL with statin therapy. , 2001, Atherosclerosis.

[7]  M. Kurabayashi,et al.  Circulating Oxidized Low Density Lipoprotein Levels: A Biochemical Risk Marker for Coronary Heart Disease , 2000, Arteriosclerosis, thrombosis, and vascular biology.

[8]  T. Shoji,et al.  Antibodies against oxidized LDL and carotid artery intima-media thickness in a healthy population. , 2000, Arteriosclerosis, thrombosis, and vascular biology.

[9]  T. Nikkari,et al.  Relationship of angiotensin-converting enzyme gene polymorphism to carotid wall thickness in middle-aged men , 1999, Journal of Molecular Medicine.

[10]  M. Mercuri.  Noninvasive imaging protocols to detect and monitor carotid atherosclerosis progression. , 1994, American journal of hypertension.

[11]  I. Winblad,et al.  Determinants of femoral and carotid artery atherosclerosis , 1994, Journal of internal medicine.

[12]  R W Barnes,et al.  Reproducibility of Noninvasive Ultrasonic Measurement of Carotid Atherosclerosis: The Asymptomatic Carotid Artery Plaque Study , 1992, Stroke.

[13]  J. Salonen,et al.  Autoantibody against oxidised LDL and progression of carotid atherosclerosis , 1992, The Lancet.

[14]  D. Steinberg,et al.  Role of oxidised low density lipoprotein in atherogenesis. , 1993, British heart journal.

[15]  W. Mckinney,et al.  Risk factors for site specific extracranial carotid artery plaque distribution as measured by B-mode ultrasound. , 1989, Journal of clinical epidemiology.