Molecular allergen profiling in horses by microarray reveals Fag e 2 from buckwheat as a frequent sensitizer

Companion animals are also affected by IgE‐mediated allergies, but the eliciting molecules are largely unknown. We aimed at refining an allergen microarray to explore sensitization in horses and compare it to the human IgE reactivity profiles.

[1]  M. Soral-Śmietana,et al.  Buckwheat Grains and Buckwheat Products - Nutritional and Prophylactic Value of their Components - a Review , 2018 .

[2]  B. Wagner,et al.  Longitudinal analysis of allergen‐specific IgE and IgG subclasses as potential predictors of insect bite hypersensitivity following first exposure to Culicoides in Icelandic horses , 2018, Veterinary dermatology.

[3]  I. Pali-Schöll,et al.  Comparing immediate‐type food allergy in humans and companion animals—revealing unmet needs , 2017, Allergy.

[4]  G. Canonica,et al.  Debates in allergy medicine: Molecular allergy diagnosis with ISAC will replace screenings by skin prick test in the future , 2017, The World Allergy Organization journal.

[5]  D. Larenas-Linnemann,et al.  Debates in Allergy Medicine: Allergy skin testing cannot be replaced by molecular diagnosis in the near future , 2017, The World Allergy Organization journal.

[6]  C. Graubner,et al.  Insect Bite Hypersensitivity in Horses is Associated with Airway Hyperreactivity , 2017, Journal of veterinary internal medicine.

[7]  L. Cecchi,et al.  Molecular Recognition Profiles and Clinical Patterns of PR-10 Sensitization in a Birch-Free Mediterranean Area , 2017, International Archives of Allergy and Immunology.

[8]  U. Jappe,et al.  Glycans and glycan-specific IgE in clinical and molecular allergology: Sensitization, diagnostics, and clinical symptoms. , 2017, The Journal of allergy and clinical immunology.

[9]  Laura H. Kahn,et al.  Checklist for One Health Epidemiological Reporting of Evidence (COHERE) , 2017, One health.

[10]  S. Ziegler,et al.  The atopic march: current insights into skin barrier dysfunction and epithelial cell‐derived cytokines , 2017, Immunological reviews.

[11]  T. Ovchinnikova,et al.  Plant Pathogenesis-Related Proteins PR-10 and PR-14 as Components of Innate Immunity System and Ubiquitous Allergens. , 2017, Current medicinal chemistry.

[12]  D. Erle,et al.  Intelectin contributes to allergen-induced IL-25, IL-33 and TSLP expression and type 2 response in asthma and atopic dermatitis , 2017, Mucosal Immunology.

[13]  R. Valenta,et al.  Molecular, Structural and Immunological Characterization of Der p 18, a Chitinase-Like House Dust Mite Allergen , 2016, PloS one.

[14]  J. Davies,et al.  EAACI Molecular Allergology User's Guide , 2016, Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology.

[15]  J. Lavoie,et al.  Inflammatory Airway Disease of Horses—Revised Consensus Statement , 2016, Journal of veterinary internal medicine.

[16]  H. Shokri.  Occurrence and distribution of Malassezia species on skin and external ear canal of horses , 2016, Mycoses.

[17]  M. Bublin,et al.  Mimotopes for Api g 5, a Relevant Cross-reactive Allergen, in the Celery-Mugwort-Birch-Spice Syndrome , 2015, Allergy, asthma & immunology research.

[18]  L. Tran,et al.  The Contribution of Buckwheat Genetic Resources to Health and Dietary Diversity , 2016, Current genomics.

[19]  R. Mueller,et al.  Allergens in veterinary medicine , 2015, Allergy.

[20]  M. Mildner,et al.  Papain Degrades Tight Junction Proteins of Human Keratinocytes In Vitro and Sensitizes C57BL/6 Mice via the Skin Independent of its Enzymatic Activity or TLR4 Activation. , 2015, The Journal of investigative dermatology.

[21]  S. Kreft,et al.  Fagopyrins and Protofagopyrins: Detection, Analysis, and Potential Phototoxicity in Buckwheat. , 2015, Journal of agricultural and food chemistry.

[22]  E. Jensen‐Jarolim,et al.  Pollen Allergies in Humans and their Dogs, Cats and Horses: Differences and Similarities , 2015, Clinical and Translational Allergy.

[23]  L. Gershwin.  Comparative immunology of allergic responses. , 2015, Annual review of animal biosciences.

[24]  M. Giuffrida,et al.  Shrimp allergy beyond Tropomyosin in Italy: clinical relevance of Arginine Kinase, Sarcoplasmic calcium binding protein and Hemocyanin. , 2014, European annals of allergy and clinical immunology.

[25]  J. Sastre,et al.  New shrimp IgE-binding proteins involved in mite-seafood cross-reactivity. , 2014, Molecular nutrition & food research.

[26]  L. Pacios,et al.  Bet v 1 from Birch Pollen Is a Lipocalin-like Protein Acting as Allergen Only When Devoid of Iron by Promoting Th2 Lymphocytes* , 2014, The Journal of Biological Chemistry.

[27]  H. Savelkoul,et al.  Evaluation of a diagnostic ELISA for insect bite hypersensitivity in horses using recombinant Obsoletus complex allergens. , 2014, Veterinary journal.

[28]  J. Bousquet,et al.  Advances in allergen-microarray technology for diagnosis and monitoring of allergy: the MeDALL allergen-chip. , 2014, Methods.

[29]  V. Fadok.  Update on equine allergies. , 2013, The Veterinary clinics of North America. Equine practice.

[30]  R. Marsella.  Equine allergy therapy: update on the treatment of environmental, insect bite hypersensitivity, and food allergies. , 2013, The Veterinary clinics of North America. Equine practice.

[31]  J. Bousquet,et al.  A WAO - ARIA - GA²LEN consensus document on molecular-based allergy diagnostics , 2013, The World Allergy Organization journal.

[32]  S. Imbesi,et al.  Italian Study on Buckwheat Allergy: Prevalence and Clinical Features of Buckwheat-Sensitized Patients in Italy , 2013, International journal of immunopathology and pharmacology.

[33]  A. Scheynius,et al.  Sensitization to Malassezia in children with atopic dermatitis combined with food allergy , 2013, Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology.

[34]  J. Heitman,et al.  Genomic Insights into the Atopic Eczema-Associated Skin Commensal Yeast Malassezia sympodialis , 2013, mBio.

[35]  R. Crameri,et al.  Equine insect bite hypersensitivity: what do we know? , 2012, Veterinary immunology and immunopathology.

[36]  J. Heitman,et al.  Malassezia Fungi Are Specialized to Live on Skin and Associated with Dandruff, Eczema, and Other Skin Diseases , 2012, PLoS pathogens.

[37]  P. Kass,et al.  Equine atopic skin disease and response to allergen-specific immunotherapy: a retrospective study at the University of California-Davis (1991-2008). , 2012, Veterinary dermatology.

[38]  P. Briza,et al.  Bet v 1‐like pollen allergens of multiple Fagales species can sensitize atopic individuals , 2011, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[39]  R. Kurukulaaratchy,et al.  Buckwheat allergy: a potential problem in 21st century Britain , 2011, BMJ Case Reports.

[40]  P. Mellor,et al.  Selective cloning, characterization, and production of the Culicoides nubeculosus salivary gland allergen repertoire associated with equine insect bite hypersensitivity. , 2011, Veterinary immunology and immunopathology.

[41]  I. Badiu,et al.  Clinical manifestations, co‐sensitizations, and immunoblotting profiles of buckwheat‐allergic patients , 2011, Allergy.

[42]  E. Cavalier,et al.  A new tool in the field of in-vitro diagnosis of allergy: preliminary results in the comparison of ImmunoCAP© 250 with the ImmunoCAP© ISAC , 2011, Clinical chemistry and laboratory medicine.

[43]  L. Vogelnest,et al.  Evaluation of the presence of house dust mites in horse rugs. , 2010, Veterinary dermatology.

[44]  R. Crameri,et al.  Cloning, production and characterization of antigen 5 like proteins from Simulium vittatum and Culicoides nubeculosus, the first cross-reactive allergen associated with equine insect bite hypersensitivity. , 2010, Veterinary immunology and immunopathology.

[45]  P. Bourdeau,et al.  Intradermal skin tests in equine dermatology: a study of 83 horses. , 2010, Equine veterinary journal.

[46]  H. Erb,et al.  Sensitization of skin mast cells with IgE antibodies to Culicoides allergens occurs frequently in clinically healthy horses. , 2009, Veterinary immunology and immunopathology.

[47]  M. de Carli,et al.  EpidemAAITO: Features of food allergy in Italian adults attending allergy clinics: a multi‐centre study , 2009, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[48]  F. Ehrensperger,et al.  Maternal transfer of IgE and subsequent development of IgE responses in the horse (Equus callabus). , 2009, Veterinary immunology and immunopathology.

[49]  J. Lidholm,et al.  Prostatic kallikrein: a new major dog allergen. , 2009, The Journal of allergy and clinical immunology.

[50]  N. E. Robinson,et al.  In vitro allergy tests compared to intradermal testing in horses with recurrent airway obstruction. , 2009, Veterinary immunology and immunopathology.

[51]  A. Egenvall,et al.  Allergen-specific IgE in Icelandic horses with insect bite hypersensitivity and healthy controls, assessed by FcepsilonR1alpha-based serology. , 2008, Veterinary immunology and immunopathology.

[52]  C. Akdis,et al.  The IgE-reactive autoantigen Hom s 2 induces damage of respiratory epithelial cells and keratinocytes via induction of IFN-gamma. , 2008, The Journal of investigative dermatology.

[53]  M. Ebisawa,et al.  A survey of patients with self‐reported severe food allergies in Japan , 2008, Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology.

[54]  B. Wagner,et al.  A comparison of intradermal testing and detection of allergen-specific immunoglobulin E in serum by enzyme-linked immunosorbent assay in horses affected with skin hypersensitivity. , 2007, Veterinary immunology and immunopathology.

[55]  C. Hong,et al.  Application of the 16-kDa buckwheat 2 S storage albumin protein for diagnosis of clinical reactivity. , 2007, Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.

[56]  H. Erb,et al.  IgE and IgG antibodies in skin allergy of the horse. , 2006, Veterinary research.

[57]  W. Thomas,et al.  The chitinase allergens Der p 15 and Der p 18 from Dermatophagoides pteronyssinus , 2006, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[58]  I. Bae,et al.  Purification and identification of angiotensin I-converting enzyme inhibitory peptide from buckwheat (Fagopyrum esculentum Moench) , 2006 .

[59]  R. Przybylski,et al.  Buckwheat concentrate reduces serum glucose in streptozotocin-diabetic rats. , 2003, Journal of agricultural and food chemistry.

[60]  T. Olivry,et al.  Identification, characterization, and cloning of a complementary DNA encoding a 60-kd house dust mite allergen (Der f 18) for human beings and dogs. , 2003, The Journal of allergy and clinical immunology.

[61]  A. Radbruch,et al.  Monoclonal anti-equine IgE antibodies with specificity for different epitopes on the immunoglobulin heavy chain of native IgE. , 2003, Veterinary immunology and immunopathology.

[62]  P. Chan.  Inhibition of tumor growth in vitro by the extract of fagopyrum cymosum (fago-c). , 2003, Life sciences.

[63]  M. W. Mueller,et al.  Microarrayed recombinant allergens for diagnosis of allergy , 2003, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[64]  T. Nagasu,et al.  Pepsin-Resistant 16-kD Buckwheat Protein Is Associated with Immediate Hypersensitivity Reaction in Patients with Buckwheat Allergy , 2002, International Archives of Allergy and Immunology.

[65]  Wayne Thomas,et al.  Microarrayed allergen molecules: diagnostic gatekeepers for allergy treatment , 2002, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[66]  D. Norbäck,et al.  Buckwheat allergy , 2001, Allergy.

[67]  G. Lorch,et al.  Comparison of immediate intradermal test reactivity with serum IgE quantitation by use of a radioallergosorbent test and two ELISA in horses with and without atopy. , 2001, Journal of the American Veterinary Medical Association.

[68]  T. Olivry,et al.  Characterization and cloning of a major high molecular weight house dust mite allergen (Der f 15) for dogs. , 2001, Veterinary immunology and immunopathology.

[69]  R. Crameri,et al.  Allergen-specific IgE levels against crude mould and storage mite extracts and recombinant mould allergens in sera from horses affected with chronic bronchitis. , 2000, Veterinary immunology and immunopathology.

[70]  J. Kayashita,et al.  Consumption of buckwheat protein lowers plasma cholesterol and raises fecal neutral sterols in cholesterol-Fed rats because of its low digestibility. , 1997, The Journal of nutrition.

[71]  B. McGorum,et al.  Quantification of histamine in plasma and pulmonary fluids from horses with chronic obstructive pulmonary disease, before and after 'natural (hay and straw) challenges'. , 1993, Veterinary immunology and immunopathology.

[72]  V. Fadok,et al.  Equine insect hypersensitivity: skin test and biopsy results correlated with clinical data. , 1990, Equine veterinary journal.

[73]  H. Larsen,et al.  Intradermal challenge of Icelandic horses with extracts of four species of the genus Culicoides. , 1989, Research in veterinary science.

[74]  E. Jensen‐Jarolim,et al.  Allergic and Atopic Eczema in Humans and Their Animals , 2017 .

[75]  B. Robibaro,et al.  Out of Breath: Asthma in Humans and Their Animals , 2017 .

[76]  I. Pali-Schöll,et al.  Allergies, with Focus on Food Allergies, in Humans and Their Animals , 2017 .

[77]  Sang-Heon Cho,et al.  Epidemiologic and clinical features of anaphylaxis in Korea. , 2008, Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.

[78]  I. Badiu,et al.  Anaphylaxis after eating Italian pizza containing buckwheat as the hidden food allergen. , 2007, Journal of investigational allergology & clinical immunology.

[79]  P. Schmid‐Grendelmeier,et al.  The role of sensitization to Malassezia sympodialis in atopic eczema. , 2006, Chemical immunology and allergy.

[80]  A. Sabbah,et al.  [Recurrent or chronic urticaria in thoroughbred race-horses: clinical observations]. , 2004, European annals of allergy and clinical immunology.

[81]  I. Kreft,et al.  Composition and technological properties of the flour and bran from common and tartary buckwheat , 2003 .

[82]  D. Norbäck,et al.  Editorial. Buckwheat allergy. 2001;56:703-704. , 2001 .

[83]  L. Poulsen,et al.  Atopic dermatitis of the face, scalp, and neck: type I reaction to the yeast Pityrosporum ovale? , 1992, The Journal of allergy and clinical immunology.