Dual opposing actions of STW 5 on TRP receptors mediate neuronal desensitisation in vitro.

[1]  H. Seeliger,et al.  Differential Desensitisation of Afferent NerveFibres by Iberis amara (STW 6) and Iberogast(STW 5) in the Murine Colon , 2018 .

[2]  P. Malfertheiner.  STW 5 (Iberogast) Therapy in Gastrointestinal Functional Disorders , 2018, Digestive Diseases.

[3]  A. Jačan,et al.  Visceral Inflammation and Immune Activation Stress the Brain , 2017, Front. Immunol..

[4]  M. Storr,et al.  Evaluating the Multitarget Effects of Combinations through Multistep Clustering of Pharmacological Data: the Example of the Commercial Preparation Iberogast , 2017, Planta Medica.

[5]  T. Smani,et al.  TRPs in Pain Sensation , 2017, Front. Physiol..

[6]  G. Boeckxstaens,et al.  Transient receptor potential ion channel function in sensory transduction and cellular signaling cascades underlying visceral hypersensitivity. , 2017, American journal of physiology. Gastrointestinal and liver physiology.

[7]  Jan Tack,et al.  Gastroduodenal Disorders. , 2016, Gastroenterology.

[8]  M. Tominaga,et al.  Reciprocal effects of capsaicin and menthol on thermosensation through regulated activities of TRPV1 and TRPM8 , 2015, The Journal of Physiological Sciences.

[9]  M. Neurath,et al.  Differential Contribution of TRPA1, TRPV4 and TRPM8 to Colonic Nociception in Mice , 2015, PloS one.

[10]  E. Kumamoto,et al.  Spontaneous L-glutamate release enhancement in rat substantia gelatinosa neurons by (-)-carvone and (+)-carvone which activate different types of TRP channel. , 2015, Biochemical and biophysical research communications.

[11]  M. Schemann,et al.  Tu1204 Mode of Action of the Herbal Medicine STW 5 to Evoke Gastric Relaxation , 2015 .

[12]  J. Cocjin,et al.  Visceral hypersensitivity and electromechanical dysfunction as therapeutic targets in pediatric functional dyspepsia. , 2014, World journal of gastrointestinal pharmacology and therapeutics.

[13]  O. Kelber,et al.  388 Effects of the Herbal Drug STW 5 and Its Individual Components on Human Intestinal Motility , 2014 .

[14]  A. Obukhov,et al.  Furanocoumarins Are a Novel Class of Modulators for the Transient Receptor Potential Vanilloid Type 1 (TRPV1) Channel* , 2014, The Journal of Biological Chemistry.

[15]  S. Jordt,et al.  TRPM8 is the principal mediator of menthol-induced analgesia of acute and inflammatory pain , 2013, PAIN®.

[16]  H. Ulrich,et al.  The monoterpene (–)‐carvone: A novel agonist of TRPV1 channels , 2013, Cytometry. Part A : the journal of the International Society for Analytical Cytology.

[17]  P. Malfertheiner,et al.  STW 5 (Iberogast®)—a safe and effective standard in the treatment of functional gastrointestinal disorders , 2012, Wiener Medizinische Wochenschrift.

[18]  T. Tomita,et al.  Role of Transient Receptor Potential Ankyrin 1 in Gastric Accommodation in Conscious Guinea Pigs , 2012, Journal of Pharmacology and Experimental Therapeutics.

[19]  A. Page,et al.  TRPA1 contributes to specific mechanically activated currents and sensory neuron mechanical hypersensitivity , 2011, The Journal of physiology.

[20]  P. Holzer.  Transient receptor potential (TRP) channels as drug targets for diseases of the digestive system , 2011, Pharmacology & therapeutics.

[21]  Jing Yang,et al.  A novel role for TRPM8 in visceral afferent function , 2011, PAIN®.

[22]  M. Kreis,et al.  Iberis Amara Desensitizes Colonic Afferent Nerve Fibers in the Mouse to 5-HT and Low-Threshold Distension but Not to Bradykinin and High-Threshold Distension , 2011 .

[23]  P. Anand,et al.  Expression of the TRPV1 receptor differs in quiescent inflammatory bowel disease with or without abdominal pain , 2010, Gut.

[24]  K. Nozawa,et al.  Molecular cloning and characterization of dog TRPA1 and AITC stimulate the gastrointestinal motility through TRPA1 in conscious dogs. , 2009, European journal of pharmacology.

[25]  K. Messlinger,et al.  High concentrations of morphine sensitize and activate mouse dorsal root ganglia via TRPV1 and TRPA1 receptors , 2009, Molecular pain.

[26]  A. Akopian,et al.  Homologous and heterologous desensitization of capsaicin and mustard oil responses utilize different cellular pathways in nociceptors , 2008, PAIN.

[27]  Kenjiro Matsumoto,et al.  Contractile effect of TRPA1 receptor agonists in the isolated mouse intestine. , 2007, European journal of pharmacology.

[28]  A. Akopian,et al.  Transient receptor potential TRPA1 channel desensitization in sensory neurons is agonist dependent and regulated by TRPV1‐directed internalization , 2007, The Journal of physiology.

[29]  B. Chizh,et al.  Potentiation of nociceptive responses to low pH injections in humans by prostaglandin E2. , 2007, The journal of pain : official journal of the American Pain Society.

[30]  Gerald Holtmann,et al.  Immune activation in patients with irritable bowel syndrome. , 2007, Gastroenterology.

[31]  P. Enck,et al.  STW 5 (Iberogast) reduces afferent sensitivity in the rat small intestine. , 2006, Phytomedicine : international journal of phytotherapy and phytopharmacology.

[32]  O. Kelber,et al.  Binding of STW 5 (Iberogast) and its components to intestinal 5-HT, muscarinic M3, and opioid receptors. , 2006, Phytomedicine : international journal of phytotherapy and phytopharmacology.

[33]  E. Quigley,et al.  Functional dyspepsia: the role of visceral hypersensitivity in its pathogenesis. , 2006, World journal of gastroenterology.

[34]  M. Simrén,et al.  A controlled study of colonic immune activity and beta7+ blood T lymphocytes in patients with irritable bowel syndrome. , 2005, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

[35]  Yi Dai,et al.  TRPA1 induced in sensory neurons contributes to cold hyperalgesia after inflammation and nerve injury. , 2005, The Journal of clinical investigation.

[36]  G. Boeckxstaens,et al.  Relationship between symptoms and hypersensitivity to rectal distension in patients with irritable bowel syndrome , 2005, Alimentary pharmacology & therapeutics.

[37]  J. Monnin,et al.  Trigeminal sensitization and desensitization in the nasal cavity: a study of cross interactions. , 2005, Rhinology.

[38]  P. Enck,et al.  The herbal preparation STW 5 (Iberogast®) desensitizes intestinal afferents in the rat small intestine 1 , 2004, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

[39]  A. Jancsó-Gábor,et al.  Functional and fine structural characteristics of the sensory neuron blocking effect of capsaicin , 2004, Naunyn-Schmiedeberg's Archives of Pharmacology.

[40]  Peter McIntyre,et al.  ANKTM1, a TRP-like Channel Expressed in Nociceptive Neurons, Is Activated by Cold Temperatures , 2003, Cell.

[41]  G. Brand,et al.  Sensitization and desensitization to allyl isothiocyanate (mustard oil) in the nasal cavity. , 2002, Chemical senses.

[42]  Z. Szallasi,et al.  Resiniferatoxin: an ultrapotent selective modulator of capsaicin-sensitive primary afferent neurons. , 1990, The Journal of pharmacology and experimental therapeutics.