Hereditary renal cell carcinoma in the Eker rat: a unique animal model for the study of cancer susceptibility.

[1]  R. Eker Familial renal adenomas in Wistar rats; a preliminary report. , 2009, Acta pathologica et microbiologica Scandinavica.

[2]  D. Wolf,et al.  Preneoplastic and Neoplastic Lesions of Rat Hereditary Renal Cell Tumors Express Markers of Proximal and Distal Nephron , 1995, Veterinary pathology.

[3]  M. Serrano,et al.  Association of rat p15INK4B/p16INK4 deletions with monosomy 5 in kidney epithelial cell lines but not primary renal tumors. , 1995, Cancer research.

[4]  T. Goldsworthy,et al.  p53 status in spontaneous and dimethylnitrosamine—induced renal cell tumors from rats , 1995, Molecular carcinogenesis.

[5]  Y. Kubo,et al.  Early detection of Knudson's two-hits in preneoplastic renal cells of the Eker rat model by the laser microdissection procedure. , 1995, Cancer research.

[6]  A. Knudson,et al.  Predisposition to renal carcinoma in the Eker rat is determined by germ-line mutation of the tuberous sclerosis 2 (TSC2) gene. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[7]  C. Walker,et al.  Increased susceptibility to in vitro transformation of cells carrying the Eker tumor susceptibility mutation. , 1994, Carcinogenesis.

[8]  A. Knudson,et al.  Genetic predisposition to transplacentally induced renal cell carcinomas in the Eker rat. , 1993, Cancer research.

[9]  T. Goldsworthy,et al.  Hereditary renal cell carcinoma in the Eker rat: a rodent familial cancer syndrome. , 1992, The Journal of urology.

[10]  T. Goldsworthy,et al.  Predisposition to renal cell carcinoma due to alteration of a cancer susceptibility gene. , 1992, Science.

[11]  A. Knudson,et al.  Hereditary renal cell carcinoma in the rat associated with nonrandom loss of chromosomes 5 and 6. , 1991, Cancer research.

[12]  A. Knudson,et al.  Altered Expression of Transforming Growth Factor-α in Hereditary Rat Renal Cell Carcinoma , 1991 .

[13]  J. Mossige,et al.  A Dominant Gene for Renal Adenomas in the Rat , 1961, Nature.

[14]  Y. Kubo,et al.  A germline insertion in the tuberous sclerosis (Tsc2) gene gives rise to the Eker rat model of dominantly inherited cancer , 1995, Nature Genetics.

[15]  A. Knudson,et al.  Spontaneous and radiation-induced renal tumors in the Eker rat model of dominantly inherited cancer. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[16]  C. Walker,et al.  Development of a quantitative in vitro transformation assay for kidney epithelial cells. , 1992, Carcinogenesis.

[17]  C. Walker,et al.  Analysis of ras DNA sequences in rat renal cell carcinoma , 1991, Molecular carcinogenesis.

[18]  J. V. Johannessen,et al.  Hereditary renal adenomas and adenocarcinomas in rats. , 1981, Diagnostic histopathology.