Multivariate Data-Driven Decision Guidance for clinical scientists

Clinical decision-support is gaining widespread attention as medical institutions and governing bodies turn towards utilising better information management for effective and efficient healthcare delivery and quality assured outcomes. A mass of data across all stages, from disease diagnosis to palliative care, is further indication of the opportunities and challenges created for effective data management, analysis, prediction and optimization techniques as parts of knowledge management in clinical environments. A Data-driven Decision Guidance Management System (DD-DGMS) architecture can encompass solutions into a single closed-loop integrated platform to empower clinical scientists to seamlessly explore a multivariate data space in search of novel patterns and correlations to inform their research and practice. The paper describes the components of such an architecture, which includes a robust data warehouse as an infrastructure for comprehensive clinical knowledge management. The proposed DD-DGMS architecture incorporates the dynamic dimensional data model as its elemental core. Given the heterogeneous nature of clinical contexts and corresponding data, the dimensional data model presents itself as an adaptive model that facilitates knowledge discovery, distribution and application, which is essential for clinical decision support. The paper reports on a trial of the DD-DGMS system prototype conducted on diabetes screening data which further establishes the relevance of the proposed architecture to a clinical context.

[1]  P. Chountas,et al.  Development of a clinical data warehouse , 2004, 2004 IDEAS Workshop on Medical Information Systems: The Digital Hospital (IDEAS-DH'04).

[2]  Carolyn McGregor,et al.  Temporal abstraction in intelligent clinical data analysis: A survey , 2007, Artif. Intell. Medicine.

[3]  Marleen de Mul,et al.  Development of a clinical data warehouse from an intensive care clinical information system , 2012, Comput. Methods Programs Biomed..

[4]  Stephan Biller,et al.  Decision-Guided Self-Architecting Framework for integrated distribution and Energy Management , 2011, ISGT 2011.

[5]  R. Glasgow,et al.  Patient age: a neglected factor when considering disease management in adults with type 2 diabetes. , 2011, Patient education and counseling.

[6]  Jun Gao,et al.  DW4TR: A Data Warehouse for Translational Research , 2011, J. Biomed. Informatics.

[7]  Jonathan M. Teich,et al.  Grand challenges in clinical decision support , 2008, J. Biomed. Informatics.

[8]  Xiaoyang Sean Wang,et al.  Decision-Guidance Management Systems (DGMS): Seamless Integration of Data Acquisition, Learning, Prediction and Optimization , 2008, Proceedings of the 41st Annual Hawaii International Conference on System Sciences (HICSS 2008).

[9]  Andrew Stranieri,et al.  Exploring novel features and decision rules to identify cardiovascular autonomic neuropathy using a hybrid of wrapper-filter based feature selection , 2010, 2010 Sixth International Conference on Intelligent Sensors, Sensor Networks and Information Processing.

[10]  D. Ewing,et al.  The natural history of diabetic autonomic neuropathy. , 1980, The Quarterly journal of medicine.

[11]  Adam Wright,et al.  A four-phase model of the evolution of clinical decision support architectures , 2008, Int. J. Medical Informatics.

[12]  S. Kotsiantis,et al.  Discretization Techniques: A recent survey , 2006 .

[13]  Herbert F. Jelinek,et al.  An innovative Multi-disciplinary Diabetes Complications Screening Program in a Rural Community: A Description and Preliminary Results of the Screening , 2006 .

[14]  Ralph Kimball,et al.  The Data Warehouse Lifecycle Toolkit , 2009 .

[15]  Andrew Stranieri,et al.  AWSum-Combining Classification with Knowledge Aquisition , 2008, Int. J. Softw. Informatics.

[16]  Christopher G. Chute,et al.  The Enterprise Data Trust at Mayo Clinic: a semantically integrated warehouse of biomedical data , 2010, J. Am. Medical Informatics Assoc..

[17]  D. Butler Translational research: Crossing the valley of death , 2008, Nature.

[18]  S. F. Roberts,et al.  Perspective: Transforming Science Into Medicine How Clinician–Scientists Can Build Bridges Across Research's “Valley of Death” , 2012, Academic medicine : journal of the Association of American Medical Colleges.

[19]  Herbert F. Jelinek,et al.  Automated classification reveals morphological factors associated with dementia , 2008, Appl. Soft Comput..

[20]  Amarnath Banerjee,et al.  Clinical decision support: Converging toward an integrated architecture , 2012, J. Biomed. Informatics.

[21]  Rómer Rosales,et al.  Guest Editorial: Special Issue on impacting patient care by mining medical data , 2010, Data Mining and Knowledge Discovery.

[22]  Sunita Sarawagi,et al.  Modeling multidimensional databases , 1997, Proceedings 13th International Conference on Data Engineering.