Clazosentan, an endothelin receptor antagonist, in patients with aneurysmal subarachnoid haemorrhage undergoing surgical clipping: a randomised, double-blind, placebo-controlled phase 3 trial (CONSCIOUS-2)

[1]  Paul Vespa,et al.  Guidelines for the Management of Aneurysmal Subarachnoid Hemorrhage: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association , 2012, Stroke.

[2]  R. Macdonald,et al.  Effect of pharmaceutical treatment on vasospasm, delayed cerebral ischemia, and clinical outcome in patients with aneurysmal subarachnoid hemorrhage: A systematic review and meta-analysis , 2011, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[3]  S. Mayer,et al.  Preventing Vasospasm Improves Outcome After Aneurysmal Subarachnoid Hemorrhage: Rationale and Design of CONSCIOUS-2 and CONSCIOUS-3 Trials , 2010, Neurocritical care.

[4]  T. Gin,et al.  Intravenous Magnesium Sulphate for Aneurysmal Subarachnoid Hemorrhage (IMASH): A Randomized, Double-Blinded, Placebo-Controlled, Multicenter Phase III Trial , 2010, Stroke.

[5]  E. Wijdicks,et al.  Multidisciplinary management and emerging therapeutic strategies in aneurysmal subarachnoid haemorrhage , 2010, The Lancet Neurology.

[6]  R. D. de Haan,et al.  Effect of Statin Treatment on Vasospasm, Delayed Cerebral Ischemia, and Functional Outcome in Patients With Aneurysmal Subarachnoid Hemorrhage: A Systematic Review and Meta-Analysis Update , 2010, Stroke.

[7]  Jeffrey J. Fletcher,et al.  Do Endothelin-Receptor Antagonists Prevent Delayed Neurological Deficits and Poor Outcomes After Aneurysmal Subarachnoid Hemorrhage?: A Meta-Analysis , 2009, Stroke.

[8]  John H. Zhang,et al.  Subarachnoid Hemorrhage: Is It Time for a New Direction? , 2009, Stroke.

[9]  A. Kolias,et al.  Pathogenesis of cerebral vasospasm following aneurysmal subarachnoid hemorrhage: Putative mechanisms and novel approaches , 2009, Journal of neuroscience research.

[10]  E. Stroes,et al.  Microthrombosis after Aneurysmal Subarachnoid Hemorrhage: An Additional Explanation for Delayed Cerebral Ischemia , 2008, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[11]  S. Mayer,et al.  Clazosentan to Overcome Neurological Ischemia and Infarction Occurring After Subarachnoid Hemorrhage (CONSCIOUS-1): Randomized, Double-Blind, Placebo-Controlled Phase 2 Dose-Finding Trial , 2008, Stroke.

[12]  A. Dumont,et al.  New insights into the causes and therapy of cerebral vasospasm following subarachnoid hemorrhage. , 2008, Drug discovery today.

[13]  V. Feigin,et al.  Calcium antagonists for aneurysmal subarachnoid haemorrhage. , 2007, The Cochrane database of systematic reviews.

[14]  R. Macdonald,et al.  Cerebral vasospasm after subarachnoid hemorrhage: the emerging revolution , 2007, Nature Clinical Practice Neurology.

[15]  M. Lauritzen,et al.  Delayed ischaemic neurological deficits after subarachnoid haemorrhage are associated with clusters of spreading depolarizations. , 2006, Brain : a journal of neurology.

[16]  B. Meyer,et al.  Clazosentan (AXV-034343), a selective endothelin A receptor antagonist, in the prevention of cerebral vasospasm following severe aneurysmal subarachnoid hemorrhage: results of a randomized, double-blind, placebo-controlled, multicenter phase IIa study. , 2005, Journal of neurosurgery.

[17]  Scott E Kasner,et al.  Utility of the NIH Stroke Scale as a Predictor of Hospital Disposition , 2003, Stroke.

[18]  S. Peery,et al.  Global and domain-specific cognitive impairment and outcome after subarachnoid hemorrhage , 2002, Neurology.

[19]  K. Waterloo,et al.  Prophylactic Hyperdynamic Postoperative Fluid Therapy after Aneurysmal Subarachnoid Hemorrhage: A Clinical, Prospective, Randomized, Controlled Study , 2001, Neurosurgery.

[20]  C Caroselli,et al.  Recommendations for the management of patients with unruptured intracranial aneurysms: A statement for healthcare professionals from the Stroke Council of the American Heart Association. , 2000, Circulation.

[21]  C. Anderson,et al.  Health outcomes 1 year after subarachnoid hemorrhage , 2000, Neurology.

[22]  J. Marler,et al.  Underlying structure of the National Institutes of Health Stroke Scale: results of a factor analysis. NINDS tPA Stroke Trial Investigators. , 1999, Stroke.

[23]  Aman B Patel,et al.  Guidelines for the Management of Aneurysmal Subarachnoid Hemorrhage: A Statement for Healthcare Professionals From a Special Writing Group of the Stroke Council, American Heart Association , 1994, Stroke.

[24]  H. Adams,et al.  The International Cooperative Study on the Timing of Aneurysm Surgery. Part 1: Overall management results. , 1990, Journal of neurosurgery.

[25]  N. Kassell,et al.  Cerebral vasospasm following aneurysmal subarachnoid hemorrhage. , 1985, Stroke.

[26]  B. Jennett,et al.  Assessment of coma and impaired consciousness. A practical scale. , 1974, Lancet.

[27]  R. Macdonald,et al.  Metaanalysis of Tirilazad Mesylate in Patients with Aneurysmal Subarachnoid Hemorrhage , 2009, Neurocritical care.

[28]  N. Knuckey,et al.  Health outcomes 1 year after subarachnoid hemorrhage , 2000 .