Antioxidants and free radical scavenging activity of Phellinus baumii (Phellinus of Hymenochaetaceae) extracts

This study was carried out to expand the utilization (for the pharmaceutical and food industries) of extracts of Phellinus baumii. Fractions rich in phenolics were extracted from P. baumii using various solvents. Antioxidant and free radical scavenging activity were studied using a β-carotene-linoleate model system and reactive oxygen species generation system. Total phenolic compounds in methanol and hot water extracts were 33.3 and 20.7 mg/100 ml, respectively; these values are higher than other solvent extracts. Therefore, methanol and hot water extracts exhibited good inhibition rates, of about 80–90%, by hydroxyl radical scavenging activity, hydrogen peroxide scavenging activity, effect of reducing power on metallic compound formation and antioxidant activity.

[1]  E. Stadtman,et al.  Age-related changes in oxidized proteins. , 1987, The Journal of biological chemistry.

[2]  G. Rosen,et al.  [23] Spin trapping of superoxide and hydroxyl radicals , 1984 .

[3]  T. Osawa,et al.  The contribution of plant food antioxidants to human health , 1995 .

[4]  P. Baeuerle,et al.  Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF‐kappa B transcription factor and HIV‐1. , 1991, The EMBO journal.

[5]  J. Abe,et al.  Fyn and JAK2 Mediate Ras Activation by Reactive Oxygen Species* , 1999, The Journal of Biological Chemistry.

[6]  J. German,et al.  Inhibition of in vitro human LDL oxidation by phenolic antioxidants from grapes and wines , 1996 .

[7]  G. Yen,et al.  Antioxidative properties of methanolic extracts from peanut hulls , 1993 .

[8]  J. Klaunig,et al.  Prevention of cytotoxicity and inhibition of intercellular communication by antioxidant catechins isolated from Chinese green tea. , 1989, Carcinogenesis.

[9]  O. Aruoma,et al.  The deoxyribose method: a simple "test-tube" assay for determination of rate constants for reactions of hydroxyl radicals. , 1987, Analytical biochemistry.

[10]  R. Singh,et al.  Antioxidant activity of grape seed (Vitis vinifera) extracts on peroxidation models in vitro , 2001 .

[11]  E. Frankel Antioxidants in lipid foods and their impact on food quality , 1996 .

[12]  V. L. Singleton,et al.  Colorimetry of Total Phenolics with Phosphomolybdic-Phosphotungstic Acid Reagents , 1965, American Journal of Enology and Viticulture.

[13]  P. Duh Antioxidant activity of burdock (Arctium lappa Linné): Its scavenging effect on free-radical and active oxygen , 1998 .

[14]  R. Prior,et al.  Antioxidant and prooxidant behavior of flavonoids: structure-activity relationships. , 1997, Free radical biology & medicine.

[15]  M. Beal,et al.  Oxidative damage in Alzheimer's , 1996, Nature.

[16]  B. Halliwell,et al.  Superoxide-dependent formation of hydroxyl radicals in the presence of iron salts. Detection of 'free' iron in biological systems by using bleomycin-dependent degradation of DNA. , 1981, The Biochemical journal.

[17]  C. Yuting,et al.  Flavonoids as superoxide scavengers and antioxidants. , 1990 .

[18]  R. Goldbohm,et al.  Consumption of black tea and cancer risk: a prospective cohort study. , 1996, Journal of the National Cancer Institute.

[19]  T. Yasuda,et al.  Ginseng extract scavenges hydroxyl radical and protects unsaturated fatty acids from decomposition caused by iron-mediated lipid peroxidation. , 1996, Free radical biology & medicine.

[20]  S. Wiseman,et al.  Antioxidants in tea. , 1997, Critical reviews in food science and nutrition.

[21]  D. Bandyopadhyay,et al.  Hydroxyl radical is the major causative factor in stress-induced gastric ulceration. , 1997, Free radical biology & medicine.

[22]  W. Koppenol,et al.  TRANSITION METALS IN OXIDATIVE STRESS: AN OVERVIEW , 1991 .

[23]  M. Babizhayev,et al.  Lipid peroxide and reactive oxygen species generating systems of the crystalline lens. , 1994, Biochimica et biophysica acta.

[24]  T. Wolever,et al.  Relationship between polyphenol intake and blood glucose response of normal and diabetic individuals. , 1984, The American journal of clinical nutrition.

[25]  M. Becana,et al.  Transition metals in legume root nodules: iron-dependent free radical production increases during nodule senescence. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[26]  K. Shimada,et al.  Antioxidative properties of xanthan on the autoxidation of soybean oil in cyclodextrin emulsion , 1992 .

[27]  J. Vinson,et al.  Plant Flavonoids, Especially Tea Flavonols, Are Powerful Antioxidants Using an in Vitro Oxidation Model for Heart Disease , 1995 .

[28]  H. Cohly,et al.  Effect of turmeric, turmerin and curcumin on H2O2-induced renal epithelial (LLC-PK1) cell injury. , 1998, Free radical biology & medicine.

[29]  P. Leanderson,et al.  Green tea polyphenols inhibit oxidant-induced DNA strand breakage in cultured lung cells. , 1997, Free radical biology & medicine.

[30]  B. Halliwell,et al.  The role of iron in ascorbate-dependent deoxyribose degradation. Evidence consistent with a site-specific hydroxyl radical generation caused by iron ions bound to the deoxyribose molecule , 1987 .

[31]  C. Fraga,et al.  (+)-Catechin prevents human plasma oxidation. , 1998, Free radical biology & medicine.

[32]  H N Graham,et al.  Green tea composition, consumption, and polyphenol chemistry. , 1992, Preventive medicine.

[33]  A. Puga,et al.  Regulation of gene expression by reactive oxygen. , 1999, Annual review of pharmacology and toxicology.

[34]  J L Witztum,et al.  Beyond cholesterol. Modifications of low-density lipoprotein that increase its atherogenicity. , 1989, The New England journal of medicine.

[35]  F. Shahidi,et al.  Optimization of Hexametaphosphate‐Assisted Extraction of Flaxseed Proteins Using Response Surface Methodology , 1996 .

[36]  Y. Niitsu,et al.  Superoxide dismutase in SAS human tongue carcinoma cell line is a factor defining invasiveness and cell motility. , 1995, Cancer research.

[37]  T. Okuda,et al.  Suppression of genotoxicity of carcinogens by (-)-epigallocatechin gallate. , 1992, Preventive medicine.