The linkage relationships of the beta and delta hemoglobin genes.

Three new families providing information on the linkage relationships between the delta and beta hemoglobin loci are reported. One of the families contains the first reported individuals having Hb S and Hb B2 in coupling. Analysis of the information found in the literture is compatible with a recombination frequency of 3 percent between beta thalassemia and the delta structural locus. This highly improbable frequency might be explained by either diagnostic errors or paternity problems in the pedigrees containing recombinants or by the conceivable possibility that certain thalassemia genes increase the probability for recombination in the chromosomal region containing the non alpha globin genes.

[1]  J. Clegg,et al.  Linkage relationships between beta- and delta-structural loci and African forms of beta thalassaemia. , 1976, Journal of medical genetics.

[2]  E. Schwartz,et al.  Globin Synthesis in the Jamaican Negro with Beta‐Thalassaemia , 1974, British journal of haematology.

[3]  W. Nance,et al.  Further evidence for close linkage of the Hb-beta and Hb-delta loci in man. , 1969, Journal of medical genetics.

[4]  J. Renwick.  Progress in mapping human autosomes. , 1969, British medical bulletin.

[5]  S. Wiesenfeld.  Sickle-Cell Trait in Human Biological and Cultural Evolution , 1967, Science.

[6]  H. Pearson,et al.  HUMAN HEMOGLOBIN GENE LINKAGE: REPORT OF A FAMILY WITH HEMOGLOBIN B2, HEMOGLOBIN S, AND BETA THALASSEMIA, INCLUDING A PROBABLE CROSSOVER BETWEEN THALASSEMIA AND DELTA LOCI. , 1965, American journal of human genetics.

[7]  D. Weatherall.  Biochemical Phenotypes of Thalassemia in the American Negro Population * , 1964, Annals of the New York Academy of Sciences.

[8]  G. Stamatoyannopoulos,et al.  Thalassaemia, Glucose-6-Phosphate Dehydrogenase Deficiency, Sickling, and Malarial Endemicity in Greece: A Study of Five Areas* , 1964, British medical journal.

[9]  S. Boyer,et al.  FURTHER EVIDENCE OF LINKAGE BETWEEN THE BETA AND DELTA LOCI GOVERNING HUMAN HEMOGLOBIN AND THE POPULATION DYNAMICS OF LINKED GENES. , 1963, American journal of human genetics.

[10]  K. Punt,et al.  Thalassemia minor associated with hemoglobin-B2 heterozygosity. A family report. , 1961, Blood.