Molecular, cellular, and tissue responses following photodynamic therapy

Photodynamic therapy (PDT) is being utilized in the treatment of a wide variety of malignant tumors. Results using PDT have been encouraging, and controlled clinical trials are currently being performed. The procedure exploits both the tumor‐localizing and ‐photosensitizing properties of hematoporphyrin derivative or its purified component, Photofrin II. When this porphyrin mixture is administered systemically, it is retained preferentially in tumor tissue as compared to surrounding normal tissue. Localized tumor destruction induced by PDT results from the photochemical generation of cytotoxic oxygen species within the tumor. This review will provide a summary of historical and current research pertaining to molecular, cellular, and tissue responses induced by PDT. Emphasis is placed on information related to the chemistry of current photosensitizers, subcellular targets, preclinical treatment parameters, and clinical responses following PDT.

[1]  C. Byrne,et al.  THE STRUCTURE OF THE ACTIVE MATERIAL IN HEMATOPORPHYRIN DERIVATIVE , 1987, Photochemistry and photobiology.

[2]  C J Gomer,et al.  Transformation and mutagenic potential of porphyrin photodynamic therapy in mammalian cells. , 1988, International journal of radiation biology and related studies in physics, chemistry, and medicine.

[3]  M R Arnfield,et al.  Treatment of Dunning R3327-AT rat prostate tumors with photodynamic therapy in combination with misonidazole. , 1986, Cancer research.

[4]  C J Gomer,et al.  ACTION SPECTRUM (620–640 nm) FOR HEMATOPORPHYRIN DERIVATIVE INDUCED CELL KILLING , 1984, Photochemistry and photobiology.

[5]  U. Nseyo,et al.  Photodynamic therapy with hematoporphyrin derivative in the treatment of superficial transitional-cell carcinoma of the bladder. , 1987, The New England journal of medicine.

[6]  C. Gomer,et al.  Expression of potentially lethal damage in Chinese hamster cells exposed to hematoporphyrin derivative photodynamic therapy. , 1986, Cancer research.

[7]  C. Gomer,et al.  Comparison of mutagenicity and induction of sister chromatid exchange in Chinese hamster cells exposed to hematoporphyrin derivative photoradiation, ionizing radiation, or ultraviolet radiation. , 1983, Cancer research.

[8]  T J Dougherty,et al.  STUDIES ON THE STRUCTURE OF PORPHYRINS CONTAINED IN PHOTOFRIN® II , 1987, Photochemistry and photobiology.

[9]  T. Dubbelman,et al.  PHOTODYNAMIC GENERATION OF HYDROXYL RADICALS BY HEMATOPORPHYRIN DERIVATIVE AND LIGHT , 1986, Photochemistry and photobiology.

[10]  J. Tulip,et al.  PHOTODYNAMIC THERAPY‐INDUCED HYPOXIA IN RAT TUMORS and NORMAL TISSUES , 1987, Photochemistry and photobiology.

[11]  I. Gigli,et al.  Delayed phase of hematoporphyrin-induced phototoxicity: modulation by complement, leukocytes, and antihistamines. , 1985, The Journal of investigative dermatology.

[12]  D. Bellnier,et al.  Photosensitization and split-dose recovery in cultured human urinary bladder carcinoma cells containing nonexchangeable hematoporphyrin derivative. , 1985, Cancer research.

[13]  P. V. Hariharan,et al.  Production of hydroxyl radicals in cell systems exposed to haematoporphyrin and red light. , 1980, International journal of radiation biology and related studies in physics, chemistry, and medicine.

[14]  F. Figge,et al.  Cancer Detection and Therapy. Affinity of Neoplastic, Embryonic, and Traumatized Tissues for Porphyrins and Metalloporphyrins.∗ , 1948, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[15]  J Moan,et al.  DNA single-strand breaks and sister chromatid exchanges induced by treatment with hematoporphyrin and light or by x-rays in human NHIK 3025 cells. , 1980, Cancer research.

[16]  C J Gomer,et al.  Differential cell photosensitivity following porphyrin photodynamic therapy. , 1988, Cancer research.

[17]  H. C. Robertson,et al.  Hematoporphyrin‐Derivative Fluorescence in Malignant Neoplasms , 1968, Journal of the South Carolina Medical Association.

[18]  C. Gomer,et al.  In vitro and in vivo light dose rate effects related to hematoporphyrin derivative photodynamic therapy. , 1985, Cancer research.

[19]  D. Cortese,et al.  Hematoporphyrin derivative phototherapy in the treatment of bronchogenic carcinoma. , 1984, Chest.

[20]  T J Dougherty,et al.  Identification of singlet oxygen as the cytotoxic agent in photoinactivation of a murine tumor. , 1976, Cancer research.

[21]  G. Buettner,et al.  Hydrogen peroxide and hydroxyl free radical production by hematoporphyrin derivative, ascorbate and light. , 1985, Cancer letters.

[22]  T J Dougherty,et al.  Interaction of hyperthermia and photoradiation therapy. , 1984, Radiation research.

[23]  T. Dougherty,et al.  Determination of [3H]- and [14C]hematoporphyrin derivative distribution in malignant and normal tissue. , 1979, Cancer research.

[24]  C. Gomer,et al.  ACUTE SKIN RESPONSE IN ALBINO MICE FOLLOWING PORPHYRIN PHOTOSENSITIZATION UNDER OXIC AND ANOXIC CONDITIONS , 1984, Photochemistry and photobiology.

[25]  D. Kessel,et al.  CHEMISTRY OF HEMATOPORPHYRIN‐DERIVED PHOTOSENSITIZERS , 1987, Photochemistry and photobiology.

[26]  H. Kato,et al.  Fiberoptic bronchoscopic photoradiation in experimentally induced canine lung cancer , 1983, Cancer.

[27]  S. Britton,et al.  Blood flow in transplantable bladder tumors treated with hematoporphyrin derivative and light. , 1984, Cancer research.

[28]  N. Miyoshi,et al.  Photoradiation therapy of bladder tumors. , 1983, The Journal of urology.

[29]  J Moan,et al.  Oxygen dependence of the photosensitizing effect of hematoporphyrin derivative in NHIK 3025 cells. , 1985, Cancer Research.

[30]  C. Gomer,et al.  Photodynamic therapy of intraocular tumors: examination of hematoporphyrin derivative distribution and long-term damage in rabbit ocular tissue. , 1985, Cancer research.

[31]  G F Babcock,et al.  Surgical stress-mediated suppression of murine natural killer cell cytotoxicity. , 1984, Cancer research.

[32]  L. Dubertret,et al.  INTERACTION OF HUMAN SERUM LOW DENSITY LIPOPROTEINS WITH PORPHYRINS: A SPECTROSCOPIC AND PHOTOCHEMICAL STUDY , 1984, Photochemistry and photobiology.

[33]  J. H. Kinsey,et al.  Detection and localization of In situ carcinoma of the bladder with hematoporphyrin derivative. , 1982, Mayo Clinic proceedings.

[34]  P. Smith,et al.  Photodynamic therapy of ascites tumours within the peritoneal cavity. , 1986, British Journal of Cancer.

[35]  J. McCaughan.  OVERVIEW OF EXPERIENCES WITH PHOTODYNAMIC THERAPY FOR MALIGNANCY IN 192 PATIENTS , 1987, Photochemistry and photobiology.

[36]  I. Gigli,et al.  Activation of the complement system in patients with porphyrias after irradiation in vivo. , 1984, The Journal of clinical investigation.

[37]  C J Gomer,et al.  DNA damage and repair in CHO cells following hematoporphyrin photoradiation. , 1980, Cancer letters.

[38]  N. Warne,et al.  Photodynamic inactivation of selected intracellular enzymes by hematoporphyrin derivative and their relationship to tumor cell viability in vitro. , 1984, Cancer letters.

[39]  C. Gomer,et al.  The effect of localized porphyrin photodynamic therapy on the induction of tumour metastasis. , 1987, British Journal of Cancer.

[40]  D. Dolphin,et al.  Some preparations and properties of porphyrins. , 1985, Advances in experimental medicine and biology.

[41]  T J Dougherty,et al.  Photoradiation therapy. II. Cure of animal tumors with hematoporphyrin and light. , 1975, Journal of the National Cancer Institute.

[42]  E. Reddi,et al.  Evidence for a major role of plasma lipoproteins as hematoporphyrin carriers in vivo. , 1984, Cancer letters.

[43]  I. Fidler,et al.  Role of Natural Killer Cells in the Destruction of Circulating Tumor Emboli , 1980 .

[44]  S. Gibson,et al.  Hematoporphyrin derivative-induced photosensitivity of mitochondrial succinate dehydrogenase and selected cytosolic enzymes of R3230AC mammary adenocarcinomas of rats. , 1984, Cancer research.

[45]  J. Moan,et al.  Uptake of hematoporphyrin derivative and sensitized photoinactivation of C3H cells with different oncogenic potential. , 1981, Cancer letters.

[46]  B. Munson.  Photodynamic inactivation of mammalian DNA-dependent RNA polymerase by hematoporphyrin and visible light. , 1979, The International journal of biochemistry.

[47]  C J Gomer,et al.  THE EVOLUTION OF PHOTODYNAMIC THERAPY TECHNIQUES IN THE TREATMENT OF INTRAOCULAR TUMORS , 1987, Photochemistry and photobiology.

[48]  D. Kessel,et al.  Photosensitization with derivatives of haematoporphyrin. , 1986, International journal of radiation biology and related studies in physics, chemistry, and medicine.

[49]  R. Anderson,et al.  Hematoporphyrin derivative photoradiation therapy in managing nevoid basal-cell carcinoma syndrome. A preliminary report. , 1984 .

[50]  C. Gomer,et al.  Hematoporphyrin derivative photoradiation therapy for the treatment of intraocular tumors: examination of acute normal ocular tissue toxicity. , 1983, Cancer research.

[51]  T J Dougherty,et al.  TIME and SEQUENCE DEPENDENT INFLUENCE OF IN VITRO PHOTODYNAMIC THERAPY (PDT) SURVIVAL BY HYPERTHERMIA , 1985, Photochemistry and photobiology.

[52]  R C Benson,et al.  Treatment of diffuse transitional cell carcinoma in situ by whole bladder hematoporphyrin derivative photodynamic therapy. , 1985, The Journal of urology.

[53]  N. Müller,et al.  Predicting the response of obstructive endobronchial tumors to photodynamic therapy , 1986, Cancer.

[54]  Photoradiation therapy of endobronchial lung cancer. Large obstructing tumors, nonobstructing tumors, and early-stage bronchial cancer lesions. , 1985 .

[55]  W. Degraff,et al.  Oxygen dependence of hematoporphyrin derivative-induced photoinactivation of Chinese hamster cells. , 1985, Cancer research.

[56]  T J Dougherty,et al.  The structure of the active component of hematoporphyrin derivative. , 1984, Progress in clinical and biological research.

[57]  G. Jori,et al.  Role of high-, low- and very low-density lipoproteins in the transport and tumor-delivery of hematoporphyrin in vivo. , 1986, Cancer letters.