Transforming growth factor-b inhibits interleukin-10 synthesis by human monocytic cells.

INTRODUCTION In addition to its role in development, cell proliferation, cell differentiation and extracellular matrix production, TGF-beta exerts key anti-inflammatory properties. In vitro studies have demonstrated that TGF-beta1 suppresses the capacity of monocytes/macrophages to release reactive oxygen intermediates [1], reactive nitrogen intermediates [2] and proinflammatory cytokines [3, 4]. In vivo, TGF-beta1-null mutation in mice [...]