A Fatal Outcome of Rhino-orbito-cerebral Mucormycosis Following Tooth Extraction: A Case Report

Rhino-orbito-cerebral mucormycosis is an uncommon aggressive life-threatening opportunistic fungal infection that affects mainly the immunocompromised population with mortality rate up to 50%. Due to its aggressive nature, early detection and prompt management are of great importance for a good prognosis. Our report describes a fatal outcome of a case of rhino-orbito-cerebral mucormycosis following tooth extraction in an uncontrolled non-insulin-dependent diabetes mellitus patient after 14 days of admission.

[1]  M. Szarejko.  Oral and Maxillofacial Infections , 2017 .

[2]  R. Webb,et al.  Lingual necrosis caused by mucormycosis in a patient with aplastic anaemia: case report. , 2014, British Journal of Oral and Maxillofacial Surgery.

[3]  H. Imran,et al.  Successful Treatment of Rhino-Orbital Mucormycosis with Posaconazole and Hyperbaric Oxygen Therapy , 2013, Pediatric hematology and oncology.

[4]  M. Aras,et al.  Mandibular mucormycosis in immunocompromised patients: report of 2 cases and review of the literature. , 2012, Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons.

[5]  Virendra Singh,et al.  Rhinocerebral mucormycosis: a diagnostic challenge and therapeutic dilemma in immunocompetent host. , 2012, Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons.

[6]  A. Al-Mujaini,et al.  Cerebro-rhino orbital mucormycosis: an update. , 2012, Journal of infection and public health.

[7]  H. Okabe,et al.  Successful treatment of rhino-orbital mucormycosis by a new combination therapy with liposomal amphotericin B and micafungin. , 2012, Auris, nasus, larynx.

[8]  K. Prasad,et al.  Role of early diagnosis and multimodal treatment in rhinocerebral mucormycosis: experience of 4 cases. , 2012, Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons.

[9]  Mauricio López Acosta,et al.  Hyperglycemic hyperosmolar state and rhino-orbital mucormycosis. , 2011, Diabetes research and clinical practice.

[10]  L. Howell,et al.  Imaging Findings of Rhinocerebral Mucormycosis , 2008, Skull base : official journal of North American Skull Base Society ... [et al.].

[11]  B. Spellberg,et al.  Iron acquisition: a novel perspective on mucormycosis pathogenesis and treatment , 2008, Current opinion in infectious diseases.

[12]  O. Lee,et al.  Early use of posaconazole in the successful treatment of rhino-orbital mucormycosis caused by Rhizopus oryzae. , 2007, The Journal of infection.

[13]  J. Piro,et al.  Disseminated rhinocerebral mucormycosis: a case report and review of the literature. , 2006, Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons.

[14]  D. Kontoyiannis,et al.  Hyperbaric oxygen as an adjunctive treatment for zygomycosis. , 2005, Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.

[15]  P. Speight.  Oral and maxillofacial pathology: a rationale for diagnosis and treatment , 2003, British Dental Journal.

[16]  H. S. Dökmetaş,et al.  Diabetic ketoacidosis and rhino-orbital mucormycosis. , 2002, Diabetes research and clinical practice.

[17]  J. Kronenberg,et al.  Rhino-Orbital and Rhino-Orbito-Cerebral Mucormycosis , 1999, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.

[18]  H. Cook,et al.  A fatal outcome from rhinocerebral mucormycosis after dental extractions: a case report. , 2001, Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons.

[19]  R. Lewandowski,et al.  Survival after rhino-orbital-cerebral mucormycosis in an immunocompetent patient. , 2000, Ophthalmology.

[20]  P. Economopoulou,et al.  Rhinocerebral mucormycosis with severe oral lesions: a case report. , 1995, Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons.

[21]  A. Baker,et al.  Infections of the head and neck in diabetes mellitus. , 1995, Infectious disease clinics of North America.

[22]  D. Underwood,et al.  MR imaging in rhinocerebral and intracranial mucormycosis with CT and pathologic correlation. , 1992, Magnetic resonance imaging.

[23]  J. K. Duplechain,et al.  Mucormycosis of the head and neck. , 1989, The Journal of the Louisiana State Medical Society.

[24]  A. Sismanis,et al.  Twenty‐Five years experience treating Cerebro‐Rhino‐Orbital mucormycosis. , 1984, The Laryngoscope.