Chondrosarcoma of the spine: a series of 16 cases and a review of the literature.

Only a few major studies of chondrosarcoma of the mobile spine have been reported. These studies have shown that spinal chondrosarcomas require complete surgical resection and are notoriously resistant to chemotherapy and radiation. We present 16 cases of chondrosarcoma of the mobile spine diagnosed at a median age of 54.5 (range 20 - 79) years. Diagnosis and treatment studies were based on both CT scans and MRI. Fifteen of our 16 patients had low-grade (grade 1-2) chondrosarcomas. All patients were treated with surgical resection. Fourteen patients had total resection while two patients had subtotal resection. The two patients who had subtotal resection died of their disease. Five of the fourteen patients who had total resection also died. The mean interval to death was 3.6 years. This study confirms that although chondrosarcomas of the spine are low grade, they are dangerous neoplasms. Even with complete resection, they have a high rate of recurrence and metastasis.

[1]  R. Laing,et al.  High-dose radiotherapy in the management of chordoma and chondrosarcoma of the skull base and cervical spine: Part 1--Clinical outcomes. , 2007, Clinical oncology (Royal College of Radiologists (Great Britain)).

[2]  R. Berk,et al.  Chondrosarcoma of the spine: 1954 to 1997. , 1999, Journal of neurosurgery.

[3]  A. Batchelor,et al.  Tumor excision and reconstruction of the upper cervical spine: a multidisciplinary approach. , 2004, Plastic and reconstructive surgery.

[4]  A. Batistatou,et al.  Chondrosarcoma of the spine: A rare case with unusual presentation , 2006, Diagnostic pathology.

[5]  R. Marcove,et al.  Sacrococcygeal chordoma , 2004, Skeletal Radiology.

[6]  P. Picci,et al.  Chondrosarcoma of the mobile spine: report on 22 cases. , 2000, Spine.

[7]  Ganesh Rao,et al.  Surgical management of primary and metastatic sarcoma of the mobile spine. , 2008, Journal of neurosurgery. Spine.

[8]  Xiao-hong Yao,et al.  Primary intradural mesenchymal chondrosarcoma of the spine in a child , 2007, Pediatric Radiology.

[9]  B. Bjerkehagen,et al.  Primary spinal chondrosarcoma: radiologic findings with pathologic correlation , 2006, Acta radiologica.

[10]  K. Unni,et al.  Chondrosarcoma of the spine. , 1989, The Journal of bone and joint surgery. American volume.

[11]  L. Kindblom,et al.  Prognostic factors and outcome of pelvic, sacral, and spinal chondrosarcomas , 2001, Cancer.

[12]  M. Uhl,et al.  Differential diagnosis of primary malignant bone tumors in the spine and sacrum. The radiological and clinical spectrum: minireview. , 2008, Neoplasma.

[13]  E. Tessitore,et al.  Primary clear-cell chondrosarcoma of the cervical spine. Case illustration. , 2006, Journal of neurosurgery. Spine.

[14]  D. Prevedello,et al.  Management of primary spinal chondrosarcoma: report of two cases causing cord compression. , 2004, Arquivos de neuro-psiquiatria.

[15]  J. Harrelson,et al.  Chondrosarcoma of Bone: Analysis of 108 Cases and Evaluation for Predictors of Outcome , 2001, Clinical orthopaedics and related research.

[16]  G. Rosen,et al.  Primary malignant tumors of the spine. , 2009, The Orthopedic clinics of North America.