Automatic Continuous-Time Blood Pressure Control in Dogs by Means of Hypotensive Drug Injection

An automated drug administration system is proposed to control the decrease in the mean arterial blood pressure of dogs. It is accomplished by identifying a model for the open loop system consisting of a syringe pump and a dog. A linear feedback controller is then determined by solving an inverse optimum control problem. The chosen controller is optimal relative to a quadratic critexion. The controller is designed so that the mean arterial blood pressure is maintained at a desired level.