The mTOR Inhibitor RAD 001 Sensitizes Tumor Cells to DNA-Damaged Induced Apoptosis through Inhibition of p 21 Translation

Iwan Beuvink,1 Anne Boulay,2 Stefano Fumagalli,1,4 Frederic Zilbermann,1 Stephan Ruetz,2 Terence O’Reilly,2 Francois Natt,3 Jonathan Hall,3 Heidi A. Lane,2,* and George Thomas1,4,* 1Friedrich Miescher Institute for Biomedical Research Maulbeerstrasse 66 P.O. Box 2543 CH-4058 Basel Switzerland 2Novartis Institutes for BioMedical Research, Basel Novartis Pharma AG Klybeckstrasse 141 CH-4002 Basel Switzerland 3Novartis Institutes for BioMedical Research, Basel Novartis Pharma AG Lichtstrasse 35 CH-4002 Basel Switzerland

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