Novel strategy for the use of leptin for obesity therapy
暂无分享,去创建一个
[1] R. Seth,et al. Combined amylin–leptin treatment lowers blood pressure and adiposity in lean and obese rats , 2011, International Journal of Obesity.
[2] C. Mantzoros,et al. Leptin administration to overweight and obese subjects for 6 months increases free leptin concentrations but does not alter circulating hormones of the thyroid and IGF axes during weight loss induced by a mild hypocaloric diet. , 2011, European journal of endocrinology.
[3] E. Ravussin,et al. The fall in leptin concentration is a major determinant of the metabolic adaptation induced by caloric restriction independently of the changes in leptin circadian rhythms. , 2011, The Journal of clinical endocrinology and metabolism.
[4] C. Mantzoros,et al. Efficacy of Metreleptin in Obese Patients With Type 2 Diabetes: Cellular and Molecular Pathways Underlying Leptin Tolerance , 2011, Diabetes.
[5] S. Davis,et al. Pramlintide and the treatment of diabetes: a review of the data since its introduction , 2011, Expert opinion on pharmacotherapy.
[6] Mary T. Brinkoetter,et al. Leptin is an effective treatment for hypothalamic amenorrhea , 2011, Proceedings of the National Academy of Sciences.
[7] R. Leibel,et al. Effects of chronic weight perturbation on energy homeostasis and brain structure in mice. , 2011, American journal of physiology. Regulatory, integrative and comparative physiology.
[8] D. Parkes,et al. Insights into amylin–leptin synergy , 2010, Trends in Endocrinology & Metabolism.
[9] J. Chan,et al. Clinical classification and treatment of congenital and acquired lipodystrophy. , 2010, Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists.
[10] G. Bray,et al. Combination Drugs for Treating Obesity , 2010, Current diabetes reports.
[11] F. Greenway,et al. Leptin replacement prevents weight loss-induced metabolic adaptation in congenital leptin-deficient patients. , 2010, The Journal of clinical endocrinology and metabolism.
[12] C. Weyer,et al. Interaction of Leptin and Amylin in the Long‐term Maintenance of Weight Loss in Diet‐induced Obese Rats , 2010, Obesity.
[13] D. Parkes,et al. Mechanisms of amylin/leptin synergy in rodent models. , 2010, Endocrinology.
[14] X. Pi-Sunyer. The Medical Risks of Obesity , 2002, Obesity surgery.
[15] E. Ravussin,et al. Enhanced Weight Loss With Pramlintide/Metreleptin: An Integrated Neurohormonal Approach to Obesity Pharmacotherapy , 2009, Obesity.
[16] M. Riddle,et al. Randomized Comparison of Pramlintide or Mealtime Insulin Added to Basal Insulin Treatment for Patients With Type 2 Diabetes , 2009, Diabetes Care.
[17] C. Weyer,et al. Amylin-mediated restoration of leptin responsiveness in diet-induced obesity: magnitude and mechanisms. , 2008, Endocrinology.
[18] Christian Weyer,et al. Leptin responsiveness restored by amylin agonism in diet-induced obesity: Evidence from nonclinical and clinical studies , 2008, Proceedings of the National Academy of Sciences.
[19] J. Chan,et al. Pharmacokinetics of Subcutaneous Recombinant Methionyl Human Leptin Administration in Healthy Subjects in the Fed and Fasting States , 2008, Clinical pharmacokinetics.
[20] G. Bray,et al. Pharmacological Treatment of the Overweight Patient , 2007, Pharmacological Reviews.
[21] P. Gorden,et al. Long-term efficacy of leptin replacement in patients with Dunnigan-type familial partial lipodystrophy. , 2007, Metabolism: clinical and experimental.
[22] J. Leahy. A Double-Blind, Placebo-Controlled Trial Assessing Pramlintide Treatment in the Setting of Intensive Insulin Therapy in Type 1 Diabetes , 2007 .
[23] T. Lutz. Amylinergic control of food intake , 2006, Physiology and Behavior.
[24] S. Heymsfield,et al. Low-dose leptin reverses skeletal muscle, autonomic, and neuroendocrine adaptations to maintenance of reduced weight. , 2005, The Journal of clinical investigation.
[25] P. Gorden,et al. Long-term efficacy of leptin replacement in patients with generalized lipodystrophy. , 2005, Diabetes.
[26] D. Kleiner,et al. Leptin reverses nonalcoholic steatohepatitis in patients with severe lipodystrophy , 2005, Hepatology.
[27] A. Volpe,et al. Recombinant human leptin in women with hypothalamic amenorrhea. , 2004, The New England journal of medicine.
[28] O G Kolterman,et al. Amylin replacement with pramlintide as an adjunct to insulin therapy improves long‐term glycaemic and weight control in Type 1 diabetes mellitus: a 1‐year, randomized controlled trial , 2004, Diabetic medicine : a journal of the British Diabetic Association.
[29] H. Münzberg,et al. Region-specific leptin resistance within the hypothalamus of diet-induced obese mice. , 2004, Endocrinology.
[30] J. Yanovski,et al. Effects of exogenous leptin on satiety and satiation in patients with lipodystrophy and leptin insufficiency. , 2004, The Journal of clinical endocrinology and metabolism.
[31] A Tremblay,et al. Thermogenesis and weight loss in obese individuals: a primary association with organochlorine pollution , 2004, International Journal of Obesity.
[32] P. Gorden,et al. Changes in body composition in patients with severe lipodystrophy after leptin replacement therapy. , 2004, Metabolism: clinical and experimental.
[33] L. Orci,et al. Rapid transformation of white adipocytes into fat-oxidizing machines , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[34] S. Schwartz,et al. Effect of 14 days' subcutaneous administration of the human amylin analogue, pramlintide (AC137), on an intravenous insulin challenge and response to a standard liquid meal in patients with IDDM , 1996, Diabetologia.
[35] W. Banks,et al. Obesity-prone rats have normal blood-brain barrier transport but defective central leptin signaling before obesity onset. , 2004, American journal of physiology. Regulatory, integrative and comparative physiology.
[36] R. Unger. Printed in U.S.A. Copyright © 2003 by The Endocrine Society doi: 10.1210/en.2003-0870 Minireview: Weapons of Lean Body Mass Destruction: The Role of Ectopic Lipids in the Metabolic Syndrome , 2022 .
[37] C. Bouchard,et al. Greater than predicted decrease in energy expenditure during exercise after body weight loss in obese men. , 2003, Clinical science.
[38] C. Weyer,et al. Pramlintide as an adjunct to insulin therapy improves long-term glycemic and weight control in patients with type 2 diabetes: a 1-year randomized controlled trial. , 2003, Diabetes care.
[39] Y. Minokoshi,et al. Role of AMP-activated protein kinase in leptin-induced fatty acid oxidation in muscle. , 2001, Biochemical Society transactions.
[40] Graham M Lord,et al. Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency. , 2002, The Journal of clinical investigation.
[41] R. Leibel. The role of leptin in the control of body weight. , 2002, Nutrition reviews.
[42] D. Mangelsdorf,et al. PPARα is necessary for the lipopenic action of hyperleptinemia on white adipose and liver tissue , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[43] K. Petersen,et al. Leptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophy. , 2002, The Journal of clinical investigation.
[44] S. Heymsfield,et al. Low dose leptin administration reverses effects of sustained weight-reduction on energy expenditure and circulating concentrations of thyroid hormones. , 2002, The Journal of clinical endocrinology and metabolism.
[45] C. Weyer,et al. A randomized study and open-label extension evaluating the long-term efficacy of pramlintide as an adjunct to insulin therapy in type 1 diabetes. , 2002, Diabetes care.
[46] M. Reitman,et al. Leptin-replacement therapy for lipodystrophy. , 2002, The New England journal of medicine.
[47] Young-Bum Kim,et al. Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase , 2002, Nature.
[48] C. Weyer,et al. Amylin replacement with pramlintide as an adjunct to insulin therapy in type 1 and type 2 diabetes mellitus: a physiological approach toward improved metabolic control. , 2001, Current pharmaceutical design.
[49] R. Unger. Leptin physiology: a second look , 2000, Regulatory Peptides.
[50] A. Tremblay,et al. Changes in energy expenditure and substrate oxidation resulting from weight loss in obese men and women: is there an important contribution of leptin? , 2000, The Journal of clinical endocrinology and metabolism.
[51] J. Sturis,et al. High-frequency oscillations in circulating amylin concentrations in healthy humans. , 2000, American journal of physiology. Endocrinology and metabolism.
[52] K. Fujioka,et al. Recombinant leptin for weight loss in obese and lean adults: a randomized, controlled, dose-escalation trial. , 1999, JAMA.
[53] A. Prentice,et al. Effects of recombinant leptin therapy in a child with congenital leptin deficiency. , 1999, The New England journal of medicine.
[54] M. Roden,et al. Acute effect of leptin on hepatic glycogenolysis and gluconeogenesis in perfused rat liver , 1999, Hepatology.
[55] C. Mantzoros,et al. Leptin in relation to resumption of menses in women with anorexia nervosa , 1998, Molecular Psychiatry.
[56] A. Klibanski,et al. Decreased leptin levels in normal weight women with hypothalamic amenorrhea: the effects of body composition and nutritional intake. , 1998, The Journal of clinical endocrinology and metabolism.
[57] S. O’Rahilly,et al. Congenital leptin deficiency is associated with severe early-onset obesity in humans , 1997, Nature.
[58] G. Pacini,et al. Amylin: History and Overview , 1997, Diabetic medicine : a journal of the British Diabetic Association.
[59] C. Newgard,et al. Direct antidiabetic effect of leptin through triglyceride depletion of tissues. , 1997, Proceedings of the National Academy of Sciences of the United States of America.
[60] C. Mantzoros,et al. Role of leptin in the neuroendocrine response to fasting , 1996, Nature.
[61] W. Colburn,et al. Pharmacokinetics and Pharmacodynamics of AC137 (25,28,29 Tripro‐Amylin, Human) After Intravenous Bolus and Infusion Doses in Patients with Insulin‐Dependent Diabetes , 1996, Journal of clinical pharmacology.
[62] B. Lowell,et al. Leptin levels reflect body lipid content in mice: Evidence for diet-induced resistance to leptin action , 1995, Nature Medicine.
[63] B. Lowell,et al. Expression of ob mRNA and its encoded protein in rodents. Impact of nutrition and obesity. , 1995, The Journal of clinical investigation.
[64] R. Leibel,et al. Changes in energy expenditure resulting from altered body weight. , 1995, The New England journal of medicine.
[65] M. Weintraub,et al. Long‐term weight control study: Conclusions , 1992, Clinical pharmacology and therapeutics.
[66] C J Hull,et al. Pharmacokinetics and pharmacodynamics. , 1979, British journal of anaesthesia.