Hypothalamic SIRT1 prevents age-associated weight gain by improving leptin sensitivity in mice
暂无分享,去创建一个
A. Harada | R. Taguchi | T. Kitamura | Tsutomu Sasaki | Masaki Kobayashi | Yong-soo Lee | O. Kikuchi | H. Yokota-Hashimoto | Y. Minokoshi | M. Yamada | N. Shibusawa | M. Shimpuku | T. Nakagawa | Takashi R. Sato | L. Tang | V. Susanti | Kosuke Amano | T. Kitazumi | Mitsutaka Kuroko | Yuki Fujita | J. Maruyama | Jun Maruyama | Hiromi Yokota-Hashimoto | Osamu Kikuchi
[1] Erik D Herzog,et al. Sirt1 extends life span and delays aging in mice through the regulation of Nk2 homeobox 1 in the DMH and LH. , 2013, Cell metabolism.
[2] S. Watkins,et al. Neuronal Sirt1 Deficiency Increases Insulin Sensitivity in Both Brain and Peripheral Tissues* , 2013, The Journal of Biological Chemistry.
[3] Wei-Ping Zhang,et al. Nicotinamide Phosphoribosyltransferase May Be Involved in Age-Related Brain Diseases , 2012, PloS one.
[4] B. Spiegelman,et al. Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human , 2012, Cell.
[5] J. Auwerx,et al. The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity. , 2012, Cell metabolism.
[6] D. Piomelli,et al. 2-arachidonoylglycerol signaling in forebrain regulates systemic energy metabolism. , 2012, Cell metabolism.
[7] M. Tremblay,et al. Modulation of leptin resistance by protein tyrosine phosphatases. , 2012, Cell metabolism.
[8] R. Coppari,et al. Direct leptin action on POMC neurons regulates glucose homeostasis and hepatic insulin sensitivity in mice. , 2012, The Journal of clinical investigation.
[9] R. Taguchi,et al. Adoptive transfer of antithyrotropin receptor (TSHR) autoimmunity from TSHR knockout mice to athymic nude mice. , 2012, Endocrinology.
[10] T. Kitamura,et al. Overexpression of FoxO1 in the hypothalamus and pancreas causes obesity and glucose intolerance. , 2012, Endocrinology.
[11] C. Doak,et al. Age standardization in mapping adult overweight and obesity trends in the WHO European Region , 2012, Obesity reviews : an official journal of the International Association for the Study of Obesity.
[12] Robert V Farese,et al. A guide to analysis of mouse energy metabolism , 2011, Nature Methods.
[13] D. Sinclair,et al. SIRT1 deacetylase in SF1 neurons protects against metabolic imbalance. , 2011, Cell metabolism.
[14] R. Ahima. Digging deeper into obesity. , 2011, The Journal of clinical investigation.
[15] Hussein Mansour,et al. Age Related Changes in NAD+ Metabolism Oxidative Stress and Sirt1 Activity in Wistar Rats , 2011, PloS one.
[16] G. Schwartz,et al. Nutrient-Sensing Hypothalamic TXNIP Links Nutrient Excess to Energy Imbalance in Mice , 2011, The Journal of Neuroscience.
[17] Gretchen A. Stevens,et al. National, regional, and global trends in body-mass index since 1980: systematic analysis of health examination surveys and epidemiological studies with 960 country-years and 9·1 million participants , 2011, The Lancet.
[18] R. Coppari,et al. A treasure trove of hypothalamic neurocircuitries governing body weight homeostasis. , 2010, Endocrinology.
[19] M. Dietrich,et al. Agrp Neurons Mediate Sirt1's Action on the Melanocortin System and Energy Balance: Roles for Sirt1 in Neuronal Firing and Synaptic Plasticity , 2010, The Journal of Neuroscience.
[20] D. Richard,et al. Effects of age and gender on Sirt 1 mRNA expressions in the hypothalamus of the mouse , 2010, Neuroscience Letters.
[21] D. Holtzman,et al. SIRT1 Promotes the Central Adaptive Response to Diet Restriction through Activation of the Dorsomedial and Lateral Nuclei of the Hypothalamus , 2010, The Journal of Neuroscience.
[22] R. Coppari,et al. SIRT1 deacetylase in POMC neurons is required for homeostatic defenses against diet-induced obesity. , 2010, Cell metabolism.
[23] T. Kitamura,et al. Induction of hypothalamic Sirt1 leads to cessation of feeding via agouti-related peptide. , 2010, Endocrinology.
[24] S. Woods,et al. The roles of leptin receptors on POMC neurons in the regulation of sex-specific energy homeostasis , 2010, Physiology & Behavior.
[25] Wentian Yang,et al. PTP1B and SHP2 in POMC neurons reciprocally regulate energy balance in mice. , 2010, The Journal of clinical investigation.
[26] C. Vaslet,et al. Hypothalamic Sirt1 Regulates Food Intake in a Rodent Model System , 2009, PloS one.
[27] A. Hofman,et al. SIRT1 Genetic Variation Is Related to BMI and Risk of Obesity , 2009, Diabetes.
[28] C. Wijmenga,et al. Genetic variations in regulatory pathways of fatty acid and glucose metabolism are associated with obesity phenotypes: a population-based cohort study , 2009, International Journal of Obesity.
[29] Sterling C. Johnson,et al. Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys , 2009, Science.
[30] I. Murano,et al. Noradrenergic parenchymal nerve fiber branching after cold acclimatisation correlates with brown adipocyte density in mouse adipose organ , 2009, Journal of anatomy.
[31] W. Hul,et al. Association of SIRT1 gene variation with visceral obesity , 2008, Human Genetics.
[32] C. Vaisse,et al. Lessons from extreme human obesity: monogenic disorders. , 2008, Endocrinology and metabolism clinics of North America.
[33] K. Reynolds,et al. Global burden of obesity in 2005 and projections to 2030 , 2008, International Journal of Obesity.
[34] A. Harada,et al. Neuron-specific recombination by Cre recombinase inserted into the murine tau locus. , 2008, Biochemical and biophysical research communications.
[35] J. Milbrandt,et al. Nampt/PBEF/Visfatin regulates insulin secretion in beta cells as a systemic NAD biosynthetic enzyme. , 2007, Cell metabolism.
[36] C. K. Song,et al. Differential activation of the sympathetic innervation of adipose tissues by melanocortin receptor stimulation. , 2007, Endocrinology.
[37] L. Guarente,et al. Genetic links between diet and lifespan: shared mechanisms from yeast to humans , 2007, Nature Reviews Genetics.
[38] P. Puigserver,et al. Resveratrol Improves Mitochondrial Function and Protects against Metabolic Disease by Activating SIRT1 and PGC-1α , 2006, Cell.
[39] H. Scrable,et al. Progressive loss of SIRT1 with cell cycle withdrawal , 2006, Aging cell.
[40] D. Accili,et al. FoxO1 protects against pancreatic beta cell failure through NeuroD and MafA induction. , 2005, Cell metabolism.
[41] G. Barsh,et al. Transcriptional regulation of agouti-related protein (Agrp) in transgenic mice. , 2004, Endocrinology.
[42] B. Rogina,et al. Sir2 mediates longevity in the fly through a pathway related to calorie restriction. , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[43] S. Belouzard,et al. Low Levels of Expression of Leptin Receptor at the Cell Surface Result from Constitutive Endocytosis and Intracellular Retention in the Biosynthetic Pathway* , 2004, Journal of Biological Chemistry.
[44] B. Lowell,et al. Leptin Receptor Signaling in POMC Neurons Is Required for Normal Body Weight Homeostasis , 2004, Neuron.
[45] H. Yoshimatsu,et al. Hypothalamic Melanocortin System Regulates Sympathetic Nerve Activity in Brown Adipose Tissue , 2004, Experimental biology and medicine.
[46] Delin Chen,et al. Negative Control of p53 by Sir2α Promotes Cell Survival under Stress , 2001, Cell.
[47] L. Guarente,et al. Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans , 2001, Nature.
[48] S. Bloom,et al. The central melanocortin system affects the hypothalamo-pituitary thyroid axis and may mediate the effect of leptin. , 2000, The Journal of clinical investigation.
[49] L. Guarente,et al. Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase , 2000, Nature.
[50] M. McVey,et al. The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms. , 1999, Genes & development.
[51] J. Friedman,et al. Abnormal splicing of the leptin receptor in diabetic mice , 1996, Nature.
[52] Steven L. Cohen,et al. Weight-reducing effects of the plasma protein encoded by the obese gene. , 1995, Science.
[53] Y. Minokoshi,et al. Accelerated norepinephrine turnover in peripheral tissues after ventromedial hypothalamic stimulation in rats , 1989, Brain Research.
[54] T. Kitamura,et al. Roles of FoxO1 and Sirt1 in the central regulation of food intake. , 2010, Endocrine journal.
[55] L. Guarente,et al. Negative control of p53 by Sir2alpha promotes cell survival under stress. , 2001, Cell.
[56] Philippe Soriano. Generalized lacZ expression with the ROSA26 Cre reporter strain , 1999, Nature Genetics.