Optimizing MR Scan Design for Model-Based T1, T2 Estimation From Steady-State Sequences

Rapid, reliable quantification of MR relaxation parameters T1 and T2 is desirable for many clinical applications. Steady-state sequences such as Spoiled Gradient-Recalled Echo (SPGR) and Dual-Echo Steady-State (DESS) are fast and wellsuited for relaxometry because the signals they produce are quite sensitive to T1 and T2 variation. However, T1, T2 estimation with these sequences typically requires multiple scans with varied sets of acquisition parameters. This paper describes a systematic framework for selecting scan types (e.g., combinations of SPGR and DESS scans) and optimizing their respective parameters (e.g., flip angles and repetition times). The method is based on a Cramér-Rao Bound (CRB)-inspired min-max optimization that finds scan parameter combinations that robustly enable precise object parameter estimation. We apply this technique to optimize combinations of SPGR and DESS scans for T1, T2 relaxometry in white matter (WM) and grey matter (GM) regions of the human brain at 3T field strength. Phantom accuracy experiments show that SPGR/DESS scan combinations are in excellent agreement with reference measurements. Phantom precision experiments show that trends in T1, T2 pooled sample standard deviations reflect CRB-based predictions. In vivo experiments show that in WM and GM, T1 and T2 estimates from a pair of optimized DESS scans exhibit precision (but not necessarily accuracy) comparable to that of optimized combinations of SPGR and DESS scans. To our knowledge, T1 maps from DESS acquisitions alone are new. This example application illustrates that scan optimization may help reveal new parameter mapping techniques from combinations of established pulse sequences.