Insulin resistance is increased in alopecia areata patients

Increased insulin resistance (IR) has been found in androgenetic alopecia in several studies. However, IR has not been investigated in alopecia areata (AA). We aimed to investigate IR in AA patients and the controls. Anthropometric and demographic data were obtained from 51 AA patients and 36 controls. We measured insulin, c-peptide and blood glucose and HOMA-IR. Demographic characteristics of the two groups were similar. AA group had higher insulin [12.5 ± 7.01 vs. 8.3 ± 3.9 µIU/mL, p = 0.001], c-peptide [2.7 ± 1.07 vs. 2.1 ± 0.6 ng/mL, p = 0.007] and HOMA-IR levels [2.8 ± 1.6 vs. 1.9 ± 0.9, p = .004] than the controls. Patient and control groups were also similar regarding lipid profiles. In this study, we found increased IR in AA patients for the first time in literature. Increased inflammatory cytokines and hypothalamic–pituitary–adrenal axis activation may be responsible for this finding. Further studies with larger sample sizes may give additional information for IR in AA.

[1]  T. Ekmekçi,et al.  The investigation of insulin resistance and metabolic syndrome in male patients with early-onset androgenetic alopecia. , 2011, European journal of dermatology : EJD.

[2]  F. Candan,et al.  The association of insulin resistance and metabolic syndrome in early androgenetic alopecia. , 2010, Singapore medical journal.

[3]  Salvador Arias-Santiago,et al.  Androgenetic alopecia and cardiovascular risk factors in men and women: a comparative study. , 2010, Journal of the American Academy of Dermatology.

[4]  S. Gregoriou,et al.  Cytokines and Other Mediators in Alopecia Areata , 2010, Mediators of inflammation.

[5]  R. Kleemann,et al.  Macrophage Migration Inhibitory Factor: Critical Role in Obesity, Insulin Resistance, and Associated Comorbidities , 2010, Mediators of inflammation.

[6]  J. Shapiro,et al.  Alopecia areata update: part I. Clinical picture, histopathology, and pathogenesis. , 2010, Journal of the American Academy of Dermatology.

[7]  A. Peters,et al.  Association of variation in the interleukin-1 gene family with diabetes and glucose homeostasis. , 2009, The Journal of clinical endocrinology and metabolism.

[8]  J. Ocampo-Candiani,et al.  Androgenetic alopecia and insulin resistance in young men , 2009, Clinical endocrinology.

[9]  J. Shapiro,et al.  Development of alopecia areata is associated with higher central and peripheral hypothalamic-pituitary-adrenal tone in the skin graft induced C3H/HeJ mouse model. , 2009, The Journal of investigative dermatology.

[10]  J. Olefsky,et al.  Insulin sensitivity: modulation by nutrients and inflammation. , 2008, The Journal of clinical investigation.

[11]  R. Watanabe,et al.  Serum BAFF and APRIL levels in patients with alopecia areata. , 2008, Journal of dermatological science.

[12]  C. Mathieu,et al.  Cytokine signalling in the beta-cell: a dual role for IFNgamma. , 2008, Biochemical Society transactions.

[13]  S. Bhattacharya,et al.  Alopecia areata progressing to totalis/universalis in non-insulin dependent diabetes mellitus (type II): failure of dexamethasone-cyclophosphamide pulse therapy. , 2008, Indian journal of dermatology, venereology and leprology.

[14]  S. R. Mahadik,et al.  Insulin Sensitivity as a Risk Factor for Common Carotid Intima Media Thickness (IMT): Its Relation to Atherosclerosis , 2007, Clinical and experimental hypertension.

[15]  Y. Altuntas,et al.  The presence of insulin resistance and comparison of various insulin sensivity indices in women with androgenetic alopecia. , 2007, European journal of dermatology : EJD.

[16]  P. Christos,et al.  Profile of 513 patients with alopecia areata: associations of disease subtypes with atopy, autoimmune disease and positive family history , 2006, Journal of the European Academy of Dermatology and Venereology : JEADV.

[17]  H. Shimizu,et al.  Promoter region polymorphism of macrophage migration inhibitory factor is strong risk factor for young onset of extensive alopecia areata , 2005, Genes and Immunity.

[18]  G. Piérard,et al.  [Cutaneous stigmata of diabetes mellitus]. , 2005, Revue medicale de Liege.

[19]  A. Sinha,et al.  Alopecia areata: autoimmune basis of hair loss. , 2004, European journal of dermatology : EJD.

[20]  Maria Hordinsky,et al.  Autoimmunity: alopecia areata. , 2004, The journal of investigative dermatology. Symposium proceedings.

[21]  A. Akar,et al.  Interferon-gamma in alopecia areata. , 2004, European journal of dermatology : EJD.

[22]  H. Shimizu,et al.  Increased macrophage migration inhibitory factor (MIF) in the sera of patients with extensive alopecia areata. , 2002, The Journal of investigative dermatology.

[23]  S. Keinänen-Kiukaanniemi,et al.  Early androgenetic alopecia as a marker of insulin resistance , 2000, The Lancet.

[24]  K. Imanishi,et al.  Cytokines in alopecia areata: contrasting cytokine profiles in localized form and extensive form (alopecia universalis). , 1996, Acta dermato-venereologica.

[25]  R. Happle,et al.  Cytokine mRNA levels in Alopecia areata before and after treatment with the contact allergen diphenylcyclopropenone. , 1994, The Journal of investigative dermatology.

[26]  Sue-Jane Wang,et al.  Increased risk for type I (insulin-dependent) diabetes in relatives of patients with alopecia areata (AA). , 1994, American journal of medical genetics.

[27]  B. Bloom,et al.  Mechanism of a Reaction in Vitro Associated with Delayed-Type Hypersensitivity , 1966, Science.