Combined application of optical methods to increase the information content of optical coherent tomography in diagnostics of neoplastic processes

A combined application of optical methods [optical coherent tomography (OCT), cross-polarisation optical coherent tomography, and fluorescence spectroscopy] is proposed for obtaining information on morphological and biochemical changes occurring in tissues in norm and pathology. It is shown that neoplastic and scar changes in esophagus can be distinguished using a combination of polarisation and standard OCT due to the difference between the depolarising properties of the tissues caused by the structural properties of collagenic fibres in stroma. It is shown that OCT combined with fluorescence spectroscopy with the use of 5-aminolevulinic acid is promising for determining the boundaries of carcinoma of the uterine cervix and vulva. It is found that the tumour boundary detected by optical methods coincides with the morphological boundary and extends beyond colposcopically determined boundary by about 2 mm.

[1]  G. Gelikonov,et al.  In vivo optical coherence tomography imaging of human skin: norm and pathology , 2000, Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging.

[2]  R. R. Snyder,et al.  Recurrence of dysplasia after loop electrosurgical excision procedures with long-term follow-up. , 2001, American journal of obstetrics and gynecology.

[3]  P. Disaia,et al.  Early invasive carcinoma of the cervix (3 to 5 mm invasion): risk factors and prognosis. A Gynecologic Oncology Group study. , 1998, American journal of obstetrics and gynecology.

[4]  Roman Kuranov,et al.  Complementary use of cross-polarization and standard OCT for differential diagnosis of pathological tissues. , 2002, Optics express.

[5]  M J Everett,et al.  Mapping of Birefringence and Thermal Damage in Tissue by use of Polarization-Sensitive Optical Coherence Tomography. , 1998, Applied optics.

[6]  Vladislav A. Kamensky,et al.  Clinical aspects of the endoscopic optical coherence tomography and the ways for improving its diagnostic value , 2002 .