Mechanical ventilation for imaging the small animal lung.

This review emphasizes some of the challenges and benefits of in vivo imaging of the small animal lung. Because mechanical ventilation plays a key role in high-quality, high-resolution imaging of the small animal lung, the article focuses particularly on the problems of ventilation support, control of breathing motion and lung volume, and imaging during different phases of the breathing cycle. Solutions for these problems are discussed primarily in relation to magnetic resonance imaging, both conventional proton imaging and the newer, hyperpolarized helium imaging of pulmonary airways. Examples of applications of these imaging solutions to normal and diseased lung are illustrated in the rat and guinea pig. Although difficult to perform, pulmonary imaging in the small animal can be a valuable source of information not only for the normal lung, but also for the lung challenged by disease.

[1]  L. Hedlund,et al.  Measurements of hyperpolarized gas properties in the lung. part III: 3He T1 , 2001, Magnetic resonance in medicine.

[2]  L W Hedlund,et al.  Registered 1H and 3He magnetic resonance microscopy of the lung , 2001, Magnetic resonance in medicine.

[3]  L W Hedlund,et al.  Detection of emphysema in rat lungs by using magnetic resonance measurements of 3He diffusion. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[4]  L W Hedlund,et al.  MR-compatible ventilator for small animals: computer-controlled ventilation for proton and noble gas imaging. , 2000, Magnetic resonance imaging.

[5]  H. Kauczor,et al.  Current issues in hyperpolarized gases in MRI: biomedical investigations and clinical applications , 2000, NMR in biomedicine.

[6]  L. Hedlund,et al.  Mixing oxygen with hyperpolarized 3He for small‐animal lung studies , 2000, NMR in biomedicine.

[7]  L W Hedlund,et al.  Spatially resolved measurements of hyperpolarized gas properties in the lung in vivo. Part I: Diffusion coefficient , 1999, Magnetic resonance in medicine.

[8]  J R MacFall,et al.  Spatially resolved measurements of hyperpolarized gas properties in the lung in vivo. Part II: T∗︁2 , 1999, Magnetic resonance in medicine.

[9]  G. Allan Johnson,et al.  Functional MR microscopy of the lung using hyperpolarized 3He , 1999 .

[10]  G. Johnson,et al.  In Vivo Microscopy: Technologies and Applications, A Workshop for Small Animal Imaging. March 18 & 19, 1999, Gaitherburg, Maryland. , 1999 .

[11]  J R Brookeman,et al.  Lung air spaces: MR imaging evaluation with hyperpolarized 3He gas. , 1999, Radiology.

[12]  L. Hedlund,et al.  Functional MR microscopy of the lung using hyperpolarized 3He. , 1999, Magnetic resonance in medicine.

[13]  A new window into the lung , 1998 .

[14]  L. Hedlund,et al.  MR microscopy of lung airways with hyperpolarized 3He , 1998, Magnetic resonance in medicine.

[15]  L W Hedlund,et al.  MR microimaging of the lung using volume projection encoding , 1997, Magnetic resonance in medicine.

[16]  L. Hedlund,et al.  Automated feedback control of body temperature for small animal studies with MR microscopy , 1997, IEEE Transactions on Biomedical Engineering.

[17]  M Thelen,et al.  Imaging of the lungs using 3he MRI: Preliminary clinical experience in 18 patients with and without lung disease , 1997, Journal of magnetic resonance imaging : JMRI.

[18]  L W Hedlund,et al.  In vivo He-3 MR images of guinea pig lungs. , 1996, Radiology.

[19]  A. Cutillo.  Application of magnetic resonance to the study of lung , 1996 .

[20]  Middleton,et al.  Nuclear relaxation of 3He in the presence of O2. , 1995, Physical review. A, Atomic, molecular, and optical physics.

[21]  L. Hedlund,et al.  MR Imaging with Hyperpolarized 3He Gas , 1995, Magnetic resonance in medicine.

[22]  W. Happer,et al.  Biological magnetic resonance imaging using laser-polarized 129Xe , 1994, Nature.

[23]  J R MacFall,et al.  MR microscopy of the rat lung using projection reconstruction , 1993, Magnetic resonance in medicine.

[24]  J. Crapo,et al.  NHLBI workshop summary. Environmental lung diseases. Relationship between acute inflammatory responses to air pollutants and chronic lung disease. , 1992, The American review of respiratory disease.

[25]  K. Netter.  Toxicology of the lung (target organ toxicology series): Edited by Donald E.] Gardner, Joseph D. Crapo and Edward J. Massaro Pages: 539, Price: $ 124,00, Raven Press, New York, 1988, ISBN 0-89004-622-0 , 1989 .

[26]  R B Smith,et al.  High frequency ventilation. , 1988, International anesthesiology clinics.

[27]  L W Hedlund,et al.  Magnetic resonance microscopy of the rat thorax and abdomen. , 1986, Investigative radiology.

[28]  L W Hedlund,et al.  A ventilator for magnetic resonance imaging. , 1986, Investigative radiology.

[29]  M. L. Wood,et al.  MR image artifacts from periodic motion. , 1985, Medical physics.

[30]  H. Hricak,et al.  Magnetic resonance imaging with respiratory gating: techniques and advantages. , 1984, AJR. American journal of roentgenology.

[31]  E. Miron,et al.  Polarization of the nuclear spins of noble-gas atoms by spin exchange with optically pumped alkali-metal atoms , 1984 .

[32]  E. Schmid,et al.  Long-term high-frequency ventilation in dogs. , 1983, The American review of respiratory disease.