Overlapping functions of bone sialoprotein and pyrophosphate regulators in directing cementogenesis.

[1]  K. Briot,et al.  Phosphate and Vitamin D Prevent Periodontitis in X-Linked Hypophosphatemia , 2017, Journal of dental research.

[2]  J. Millán,et al.  Conditional Alpl Ablation Phenocopies Dental Defects of Hypophosphatasia , 2017, Journal of dental research.

[3]  J. Millán,et al.  Phosphate induces formation of matrix vesicles during odontoblast-initiated mineralization in vitro. , 2016, Matrix biology : journal of the International Society for Matrix Biology.

[4]  C. Farquharson,et al.  Role of PHOSPHO1 in Periodontal Development and Function , 2016, Journal of dental research.

[5]  A. George,et al.  DSPP Is Essential for Normal Development of the Dental-Craniofacial Complex , 2016, Journal of dental research.

[6]  S. Papagerakis,et al.  MEPE Localization in the Craniofacial Complex and Function in Tooth Dentin Formation , 2016, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[7]  J. Millán,et al.  Alkaline Phosphatase and Hypophosphatasia , 2015, Calcified Tissue International.

[8]  C. Farquharson,et al.  The functional co-operativity of tissue-nonspecific alkaline phosphatase (TNAP) and PHOSPHO1 during initiation of skeletal mineralization. , 2015, Biochemistry and biophysics reports.

[9]  M. Somerman,et al.  Mineralization defects in cementum and craniofacial bone from loss of bone sialoprotein. , 2015, Bone.

[10]  D. Holdsworth,et al.  Mechanical Forces Exacerbate Periodontal Defects in Bsp-null Mice , 2015, Journal of dental research.

[11]  R. Sah,et al.  Periodontal Defects in the A116T Knock-in Murine Model of Odontohypophosphatasia , 2015, Journal of dental research.

[12]  R. Hinton,et al.  Osterix Controls Cementoblast Differentiation through Downregulation of Wnt-signaling via Enhancing DKK1 Expression , 2015, International journal of biological sciences.

[13]  J. Millán,et al.  Counter-regulatory phosphatases TNAP and NPP1 temporally regulate tooth root cementogenesis , 2014, International Journal of Oral Science.

[14]  G. Hunter,et al.  Osteopontin mediates mineralization and not osteogenic cell development in vitro. , 2014, The Biochemical journal.

[15]  J. Millán,et al.  Ablation of Osteopontin Improves the Skeletal Phenotype of Phospho1−/− Mice , 2014, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[16]  M. Somerman,et al.  Rare Bone Diseases and Their Dental, Oral, and Craniofacial Manifestations , 2014, Journal of dental research.

[17]  M. Somerman,et al.  The rachitic tooth. , 2014, Endocrine reviews.

[18]  Y. Liu,et al.  Failure to process dentin sialophosphoprotein into fragments leads to periodontal defects in mice. , 2013, European journal of oral sciences.

[19]  M. Taketo,et al.  Excessive Wnt/β-catenin signaling disturbs tooth-root formation. , 2013, Journal of periodontal research.

[20]  J. Millán,et al.  In Vivo Overexpression of Tissue‐Nonspecific Alkaline Phosphatase Increases Skeletal Mineralization and Affects the Phosphorylation Status of Osteopontin , 2013, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[21]  M. McKee,et al.  Compounded PHOSPHO1/ALPL Deficiencies Reduce Dentin Mineralization , 2013, Journal of dental research.

[22]  R. D'Souza,et al.  Loss of dentin sialophosphoprotein leads to periodontal diseases in mice. , 2013, Journal of periodontal research.

[23]  J. Aubin,et al.  Deficiency in Acellular Cementum and Periodontal Attachment in Bsp Null Mice , 2013, Journal of dental research.

[24]  M. McKee,et al.  Tooth root dentin mineralization defects in a mouse model of hypophosphatasia , 2013, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[25]  J. Millán The Role of Phosphatases in the Initiation of Skeletal Mineralization , 2012, Calcified Tissue International.

[26]  Harvey A. Goldberg and Graeme K. Hunter Functional Domains of Bone Sialoprotein , 2012 .

[27]  C. Farquharson,et al.  The importance of the SIBLING family of proteins on skeletal mineralisation and bone remodelling. , 2012, The Journal of endocrinology.

[28]  B. Foster Methods for studying tooth root cementum by light microscopy , 2012, International Journal of Oral Science.

[29]  J. Millán,et al.  Enzyme replacement prevents enamel defects in hypophosphatasia mice , 2012, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[30]  J. Millán,et al.  Central Role of Pyrophosphate in Acellular Cementum Formation , 2012, PloS one.

[31]  B. de Crombrugghe,et al.  Genetic evidence for the vital function of osterix in cementogenesis , 2012, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[32]  B. Christensen,et al.  C-terminal Modification of Osteopontin Inhibits Interaction with the αVβ3-Integrin* , 2011, The Journal of Biological Chemistry.

[33]  N. Hatch,et al.  Ectonucleotide Pyrophosphatase/Phosphodiesterase-1 (ENPP1) Protein Regulates Osteoblast Differentiation , 2011, The Journal of Biological Chemistry.

[34]  X. Yang,et al.  Constitutive stabilization of ß-catenin in the dental mesenchyme leads to excessive dentin and cementum formation. , 2011, Biochemical and biophysical research communications.

[35]  R. Rutherford,et al.  The Progressive Ankylosis Protein Regulates Cementum Apposition and Extracellular Matrix Composition , 2011, Cells Tissues Organs.

[36]  Jeffrey J. Gray,et al.  Enzyme Replacement Therapy Prevents Dental Defects in a Model of Hypophosphatasia , 2011, Journal of dental research.

[37]  M. McKee,et al.  Loss of Skeletal Mineralization by the Simultaneous Ablation of PHOSPHO1 and Alkaline Phosphatase Function: A Unified Model of the Mechanisms of Initiation of Skeletal Calcification , 2010, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[38]  G. Lajoie,et al.  Phosphorylation of Ser136 is critical for potent bone sialoprotein-mediated nucleation of hydroxyapatite crystals. , 2010, The Biochemical journal.

[39]  J. Millán,et al.  Inhibition of PHOSPHO1 activity results in impaired skeletal mineralization during limb development of the chick. , 2010, Bone.

[40]  R. Braatz,et al.  Elongated Polyproline Motifs Facilitate Enamel Evolution through Matrix Subunit Compaction , 2009, PLoS biology.

[41]  Shing-Hwa Liu,et al.  Osteopontin increases migration and MMP‐9 up‐regulation via αvβ3 integrin, FAK, ERK, and NF‐κB‐dependent pathway in human chondrosarcoma cells , 2009, Journal of cellular physiology.

[42]  J. Gordon,et al.  Bone sialoprotein stimulates focal adhesion‐related signaling pathways: Role in migration and survival of breast and prostate cancer cells , 2009, Journal of cellular biochemistry.

[43]  B. Lanske,et al.  Aberrant cementum phenotype associated with the hypophosphatemic hyp mouse. , 2009, Journal of periodontology.

[44]  M. Somerman,et al.  Phosphate Regulates Osteopontin Gene Transcription , 2009, Journal of dental research.

[45]  Z. von Marschall,et al.  Dentin Matrix Protein-1 Isoforms Promote Differential Cell Attachment and Migration* , 2008, Journal of Biological Chemistry.

[46]  N. Fedarko,et al.  Structural requirements for bone sialoprotein binding and modulation of matrix metalloproteinase-2. , 2008, Biochemistry.

[47]  M. McKee,et al.  Matrix Gla Protein Inhibition of Tooth Mineralization , 2008, Journal of dental research.

[48]  J. Gordon,et al.  Activation of the Mitogen-Activated Protein Kinase Pathway by Bone Sialoprotein Regulates Osteoblast Differentiation , 2008, Cells Tissues Organs.

[49]  Jian Q. Feng,et al.  Pathogenic role of Fgf23 in Dmp1-null mice. , 2008, American journal of physiology. Endocrinology and metabolism.

[50]  L. Bonewald,et al.  Periodontal Breakdown in the Dmp1 Null Mouse Model of Hypophosphatemic Rickets , 2008, Journal of dental research.

[51]  J. Rossant,et al.  Bone sialoprotein plays a functional role in bone formation and osteoclastogenesis , 2008, The Journal of experimental medicine.

[52]  G. Lajoie,et al.  Control of calcium oxalate crystal growth by face-specific adsorption of an osteopontin phosphopeptide. , 2007, Journal of the American Chemical Society.

[53]  J. Gordon,et al.  Bone sialoprotein expression enhances osteoblast differentiation and matrix mineralization in vitro. , 2007, Bone.

[54]  M. McKee,et al.  Pyrophosphate Inhibits Mineralization of Osteoblast Cultures by Binding to Mineral, Up-regulating Osteopontin, and Inhibiting Alkaline Phosphatase Activity* , 2007, Journal of Biological Chemistry.

[55]  J. Millán,et al.  Functional Involvement of PHOSPHO1 in Matrix Vesicle–Mediated Skeletal Mineralization , 2007, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[56]  M. McKee,et al.  Rescue of odontogenesis in Dmp1-deficient mice by targeted re-expression of DMP1 reveals roles for DMP1 in early odontogenesis and dentin apposition in vivo. , 2007, Developmental biology.

[57]  U. Ripamonti Recapitulating development: a template for periodontal tissue engineering. , 2007, Tissue engineering.

[58]  T. Strom,et al.  DMP1 mutations in autosomal recessive hypophosphatemia implicate a bone matrix protein in the regulation of phosphate homeostasis , 2006, Nature Genetics.

[59]  L. Bonewald,et al.  Loss of DMP1 causes rickets and osteomalacia and identifies a role for osteocytes in mineral metabolism , 2006, Nature Genetics.

[60]  R. Terkeltaub,et al.  Elevated Skeletal Osteopontin Levels Contribute to the Hypophosphatasia Phenotype in Akp2−/− Mice , 2006, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[61]  C. Guenther,et al.  Mineral Formation in Joints Caused by Complete or Joint‐Specific Loss of ANK Function , 2006, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[62]  R. Beyer,et al.  Extracellular Phosphate Alters Cementoblast Gene Expression , 2006, Journal of dental research.

[63]  D. Kingsley,et al.  Biochemical and genetic analysis of ANK in arthritis and bone disease. , 2006, American journal of human genetics.

[64]  M. Somerman,et al.  Regulation of Cementoblast Gene Expression by Inorganic Phosphate In Vitro , 2006, Calcified Tissue International.

[65]  S. Coburn,et al.  Cementum and Dentin in Hypophosphatasia , 2005, Journal of dental research.

[66]  Q. Tu,et al.  BSP and RANKL Induce Osteoclastogenesis and Bone Resorption Synergistically , 2005, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[67]  D. Bosshardt Are Cementoblasts a Subpopulation of Osteoblasts or a Unique Phenotype? , 2005, Journal of dental research.

[68]  N. Fedarko,et al.  Bone sialoprotein, matrix metalloproteinase 2, and alpha(v)beta3 integrin in osteotropic cancer cell invasion. , 2004, Journal of the National Cancer Institute.

[69]  O. Baba,et al.  Post-translational modifications of sibling proteins and their roles in osteogenesis and dentinogenesis. , 2004, Critical reviews in oral biology and medicine : an official publication of the American Association of Oral Biologists.

[70]  R. Terkeltaub,et al.  Concerted regulation of inorganic pyrophosphate and osteopontin by akp2, enpp1, and ank: an integrated model of the pathogenesis of mineralization disorders. , 2004, The American journal of pathology.

[71]  G. Lajoie,et al.  Inhibition of hydroxyapatite formation by osteopontin phosphopeptides. , 2004, The Biochemical journal.

[72]  M. Somerman,et al.  Noggin Gene Delivery Inhibits Cementoblast-Induced Mineralization , 2004, Connective tissue research.

[73]  N. Fedarko,et al.  Bone sialoprotein, matrix metalloproteinase 2, and alpha(v)beta3 integrin in osteotropic cancer cell invasion. , 2004, Journal of the National Cancer Institute.

[74]  G. Beck,et al.  Osteopontin Regulation by Inorganic Phosphate Is ERK1/2-, Protein Kinase C-, and Proteasome-dependent* , 2003, Journal of Biological Chemistry.

[75]  M. Somerman,et al.  Cementum engineering with three-dimensional polymer scaffolds. , 2003, Journal of biomedical materials research. Part A.

[76]  R. D'Souza,et al.  Tooth eruption and cementum formation in the Runx2/Cbfa1 heterozygous mouse. , 2003, Archives of oral biology.

[77]  A. Kulkarni,et al.  Dentin Sialophosphoprotein Knockout Mouse Teeth Display Widened Predentin Zone and Develop Defective Dentin Mineralization Similar to Human Dentinogenesis Imperfecta Type III* , 2003, Journal of Biological Chemistry.

[78]  R. Terkeltaub,et al.  Linked Deficiencies in Extracellular PPi and Osteopontin Mediate Pathologic Calcification Associated With Defective PC‐1 and ANK Expression , 2003, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[79]  J. Gordon,et al.  Delineation of the Hydroxyapatite-nucleating Domains of Bone Sialoprotein* , 2003, The Journal of Biological Chemistry.

[80]  N. Fedarko,et al.  Six Genes Expressed in Bones and Teeth Encode the Current Members of the SIBLING Family of Proteins , 2003, Connective tissue research.

[81]  M. Somerman,et al.  Exploring the Origins of Cementoblasts and their Trigger Factors , 2003, Connective tissue research.

[82]  M. Somerman,et al.  Cementum: A Phosphate-sensitive Tissue , 2002, Journal of dental research.

[83]  R. Terkeltaub,et al.  Tissue-nonspecific alkaline phosphatase and plasma cell membrane glycoprotein-1 are central antagonistic regulators of bone mineralization , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[84]  D. Torchia,et al.  Flexible structures of SIBLING proteins, bone sialoprotein, and osteopontin. , 2001, Biochemical and biophysical research communications.

[85]  A. Chambers,et al.  Functional analysis of bone sialoprotein: identification of the hydroxyapatite-nucleating and cell-binding domains by recombinant peptide expression and site-directed mutagenesis. , 2000, Bone.

[86]  E. Moran,et al.  Phosphate is a specific signal for induction of osteopontin gene expression. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[87]  D. Kingsley,et al.  Role of the mouse ank gene in control of tissue calcification and arthritis. , 2000, Science.

[88]  C. Giachelli,et al.  Phosphorylation of Osteopontin Is Required for Inhibition of Vascular Smooth Muscle Cell Calcification* , 2000, The Journal of Biological Chemistry.

[89]  M. Young,et al.  Factor H Binding to Bone Sialoprotein and Osteopontin Enables Tumor Cell Evasion of Complement-mediated Attack* , 2000, The Journal of Biological Chemistry.

[90]  J. Windle,et al.  Employing a transgenic animal model to obtain cementoblasts in vitro. , 2000, Journal of periodontology.

[91]  Ying Chen,et al.  Matrix Vesicle Plasma Cell Membrane Glycoprotein‐1 Regulates Mineralization by Murine Osteoblastic MC3T3 Cells , 1999, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[92]  V. Everts,et al.  Root Development in Mice Lacking Functional Tissue Non-specific Alkaline Phosphatase Gene: Inhibition of Acellular Cementum Formation , 1999, Journal of dental research.

[93]  A. Symons,et al.  Expression of Transforming Growth Factor-beta 1 (TGF-β1) in the Developing Periodontium of Rats , 1998, Journal of dental research.

[94]  D. Torchia,et al.  Characterization of Native and Recombinant Bone Sialoprotein: Delineation of the Mineral‐Binding and Cell Adhesion Domains and Structural Analysis of the RGD Domain , 1997, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[95]  M. Glimcher,et al.  Phosphorylation of Purified Bovine Bone Sialoprotein and Osteopontin by Protein Kinases* , 1996, The Journal of Biological Chemistry.

[96]  P. Hauschka,et al.  Nucleation and inhibition of hydroxyapatite formation by mineralized tissue proteins. , 1996, The Biochemical journal.

[97]  M. McKee,et al.  Extracellular matrix in tooth cementum and mantle dentin: Localization of osteopontin and other noncollagenous proteins, plasma proteins, and glycoconjugates by electron microscopy , 1996, The Anatomical record.

[98]  L. Hammarström,et al.  Root surface defects in rat molar induced by 1-hydroxyethylidene-1,1-bisphosphonate. , 1996, Acta odontologica Scandinavica.

[99]  G. Hunter,et al.  Determination of the hydroxyapatite-nucleating region of bone sialoprotein. , 1996, Connective tissue research.

[100]  P. Højrup,et al.  Posttranslational modifications of bovine osteopontin: Identification of twenty‐eight phosphorylation and three O‐glycosylation sites , 1995, Protein science : a publication of the Protein Society.

[101]  A. Chambers,et al.  Site‐directed mutagenesis of the arginine‐glycine‐aspartic acid sequence in osteopontin destroys cell adhesion and migration functions , 1995, Journal of cellular biochemistry.

[102]  M. Somerman,et al.  Role of two mineral-associated adhesion molecules, osteopontin and bone sialoprotein, during cementogenesis. , 1995, Connective tissue research.

[103]  M. Somerman,et al.  Bone sialoprotein is localized to the root surface during cementogenesis , 1994, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[104]  K. Hultenby,et al.  Disturbances of cementum formation induced by single injection of 1-hydroxyethylidene-1,1-bisphosphonate (HEBP) in rats: light and scanning electron microscopic studies. , 1994, Scandinavian journal of dental research.

[105]  G. Hunter,et al.  Modulation of crystal formation by bone phosphoproteins: role of glutamic acid-rich sequences in the nucleation of hydroxyapatite by bone sialoprotein. , 1994, The Biochemical journal.

[106]  R. Terkeltaub,et al.  Causal link between nucleotide pyrophosphohydrolase overactivity and increased intracellular inorganic pyrophosphate generation demonstrated by transfection of cultured fibroblasts and osteoblasts with plasma cell membrane glycoprotein-1. Relevance to calcium pyrophosphate dihydrate deposition disea , 1994, Arthritis and rheumatism.

[107]  W. Grzesik,et al.  Bone matrix RGD glycoproteins: Immunolocalization and interaction with human primary osteoblastic bone cells in vitro , 1994, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[108]  G. Hunter,et al.  Nucleation of hydroxyapatite by bone sialoprotein. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[109]  A. Craig,et al.  Expression of attachment proteins during cementogenesis. , 1990, Journal de biologie buccale.

[110]  D. Heinegård,et al.  Cloning and sequence analysis of rat bone sialoprotein (osteopontin) cDNA reveals an Arg-Gly-Asp cell-binding sequence. , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[111]  V. Everts,et al.  Effects of 1-hydroxyethylidene-1, 1-bisphosphonate (HEBP) on the formation of dentin and the periodontal attachment apparatus in the mouse. , 1985, The American journal of anatomy.

[112]  R. Bruckner,et al.  Hypophosphatasia with premature shedding of teeth and aplasia of cementum. , 1962, Oral surgery, oral medicine, and oral pathology.