COMPARISON OF SACKS AND A NEW COLLOID HYPEROSMOLAR SOLUTION FOR HYPOTHERMIC RENAL STORAGE

SUMMARY A new colloid hyperosmolar solution with high concentrations of proteins, potassium, and glucose has been favorably compared with a crystalloid, intracellular, and hyperosmolar solution (Sacks II) for 24-hr hypothermic storage of ischemic and nonischemic canine kidneys. Sixty minutes of warm ischemia was overcome by all kidneys flushed with the colloid hyperosmolar solution. In four of six ischemic kidneys flushed with Sacks' solution the function returned to normal limits. Hypothermic storage (24 hr) without warm ischemia did not cause any deleterious effects on either one of the flushed group of kidneys. Thirty minutes of warm ischemia followed by 24-hr hypothermic storage was tolerated by most of the kidneys (83%) flushed with the colloid hyperosmolar solution and one-half of the kidneys flushed with the crystalloid hyperosmolar solution. Sixty minutes of warm ischemia and 24-hr hypothermic storage was detrimental to 50% of the kidneys flushed with the colloid hyperosmolar solution. Hypothermic storage is a less expensive method for preserving kidneys for short periods of time. There are basically two solutions in current use for kidney hypothermic storage: Collins' solution (3–5) with high normal osmolarity and intracellular composition, and Sacks' solution (12), hyperosmolar with intracellular concentration of electrolytes. This paper compares the effectiveness of Sacks' solution and a new colloid hyperosmolar solution for 24-hr hypothermic storage of ischemic and nonis-chemic kidneys.