Poxvirus encoded eIF2α homolog, K3 family proteins, is a key determinant of poxvirus host species specificity.

[1]  Chorong Park,et al.  Species‐specific inhibition of antiviral protein kinase R by capripoxviruses and vaccinia virus , 2019, Annals of the New York Academy of Sciences.

[2]  Zev N. Kronenberg,et al.  Emergence of a Viral RNA Polymerase Variant during Gene Copy Number Amplification Promotes Rapid Evolution of Vaccinia Virus , 2016, Journal of Virology.

[3]  B. Moss,et al.  Opposing Roles of Double-Stranded RNA Effector Pathways and Viral Defense Proteins Revealed with CRISPR-Cas9 Knockout Cell Lines and Vaccinia Virus Mutants , 2016, Journal of Virology.

[4]  G. McFadden,et al.  Myxoma virus M156 is a specific inhibitor of rabbit PKR but contains a loss-of-function mutation in Australian virus isolates , 2016, Proceedings of the National Academy of Sciences.

[5]  A. Geballe,et al.  Essential role of protein kinase R antagonism by TRS1 in human cytomegalovirus replication. , 2016, Virology.

[6]  P. Earl,et al.  Generation of Recombinant Vaccinia Viruses , 2015, Current protocols in microbiology.

[7]  J. Kitzman,et al.  Experimental Evolution Identifies Vaccinia Virus Mutations in A24R and A35R That Antagonize the Protein Kinase R Pathway and Accompany Collapse of an Extragenic Gene Amplification , 2015, Journal of Virology.

[8]  Stefan Rothenburg,et al.  Ectopic Expression of Vaccinia Virus E3 and K3 Cannot Rescue Ectromelia Virus Replication in Rabbit RK13 Cells , 2015, PloS one.

[9]  Jay Shendure,et al.  Adaptive Gene Amplification As an Intermediate Step in the Expansion of Virus Host Range , 2014, PLoS pathogens.

[10]  Jay Shendure,et al.  Poxviruses Deploy Genomic Accordions to Adapt Rapidly against Host Antiviral Defenses , 2012, Cell.

[11]  G. McFadden,et al.  Myxoma Virus M064 Is a Novel Member of the Poxvirus C7L Superfamily of Host Range Factors That Controls the Kinetics of Myxomatosis in European Rabbits , 2012, Journal of Virology.

[12]  Jingxin Cao,et al.  Comparative Analysis of Poxvirus Orthologues of the Vaccinia Virus E3 Protein: Modulation of Protein Kinase R Activity, Cytokine Responses, and Virus Pathogenicity , 2011, Journal of Virology.

[13]  B. Moss,et al.  Genome-Wide Analysis of the 5′ and 3′ Ends of Vaccinia Virus Early mRNAs Delineates Regulatory Sequences of Annotated and Anomalous Transcripts , 2011, Journal of Virology.

[14]  H. Baker,et al.  Roles of Vaccinia Virus Genes E3L and K3L and Host Genes PKR and RNase L during Intratracheal Infection of C57BL/6 Mice , 2010, Journal of Virology.

[15]  M. Esteban,et al.  The interferon system and vaccinia virus evasion mechanisms. , 2009, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.

[16]  Jingxin Cao,et al.  Vaccinia Virus E3 Suppresses Expression of Diverse Cytokines through Inhibition of the PKR, NF-κB, and IRF3 Pathways , 2009, Journal of Virology.

[17]  K. Dittmar,et al.  Rapid evolution of protein kinase PKR alters sensitivity to viral inhibitors , 2008, Nature Structural &Molecular Biology.

[18]  Nels C. Elde,et al.  Protein kinase R reveals an evolutionary model for defeating viral mimicry , 2008, Nature.

[19]  Jingxin Cao,et al.  Antagonizing activity of vaccinia virus E3L against human interferons in Huh7 cells. , 2008, Virology.

[20]  Arvin C. Dar,et al.  Higher-Order Substrate Recognition of eIF2α by the RNA-Dependent Protein Kinase PKR , 2005, Cell.

[21]  F. Sicheri,et al.  X-ray crystal structure and functional analysis of vaccinia virus K3L reveals molecular determinants for PKR subversion and substrate recognition. , 2002, Molecular cell.

[22]  J. Langland,et al.  The role of the PKR-inhibitory genes, E3L and K3L, in determining vaccinia virus host range. , 2002, Virology.

[23]  D. Tscharke,et al.  The Vaccinia Virus Superoxide Dismutase-Like Protein (A45R) Is a Virion Component That Is Nonessential for Virus Replication , 2001, Journal of Virology.

[24]  K. Ozato,et al.  Pseudosubstrate inhibition of protein kinase PKR by swine pox virus C8L gene product. , 2000, Virology.

[25]  G. McFadden,et al.  The complete DNA sequence of myxoma virus. , 1999, Virology.

[26]  B. Moss,et al.  Compact, synthetic, vaccinia virus early/late promoter for protein expression. , 1997, BioTechniques.

[27]  J. Silverman,et al.  Regulation of the protein kinase PKR by the vaccinia virus pseudosubstrate inhibitor K3L is dependent on residues conserved between the K3L protein and the PKR substrate eIF2alpha , 1997, Molecular and cellular biology.

[28]  M. Katze,et al.  Interaction of the interferon-induced PKR protein kinase with inhibitory proteins P58IPK and vaccinia virus K3L is mediated by unique domains: implications for kinase regulation , 1996, Molecular and cellular biology.

[29]  E. Paoletti,et al.  Distinct patterns of IFN sensitivity observed in cells infected with vaccinia K3L- and E3L- mutant viruses. , 1995, Virology.

[30]  O. Elroy-Stein,et al.  Recombinant vaccinia virus K3L gene product prevents activation of double-stranded RNA-dependent, initiation factor 2 alpha-specific protein kinase. , 1993, The Journal of biological chemistry.

[31]  H. W. Chang,et al.  The E3L and K3L vaccinia virus gene products stimulate translation through inhibition of the double-stranded RNA-dependent protein kinase by different mechanisms , 1993, Journal of virology.

[32]  O. Elroy-Stein,et al.  The vaccinia virus K3L gene product potentiates translation by inhibiting double-stranded-RNA-activated protein kinase and phosphorylation of the alpha subunit of eukaryotic initiation factor 2 , 1992, Journal of virology.

[33]  E. Paoletti,et al.  Vaccinia virus-encoded elF-2α homolog abrogates the antiviral effect of interferon , 1991 .

[34]  B. Williams,et al.  Structure and function of the protein kinase R. , 2007, Current topics in microbiology and immunology.