Characterization of tissue mimicking phantoms for acoustic radiation force impulse imaging

Tissue mimicking phantoms play a crucial role in the development of Acoustic Radiation Force Impulse Imaging. This paper deals with the preparation and study of agar based tissue mimicking phantoms. Acoustic and elastic properties are studied for various concentration of agar samples (1.7%-10% by weight). Acoustic properties are measured using pulse echo transmit receive principle. Young's modulus of the samples are measured using compression test. Reproducible phantom preparation procedures are standardised for matching various properties of normal and abnormal human soft tissues.

[1]  T. Krouskop,et al.  Phantom materials for elastography , 1997, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[2]  Jeffrey C. Bamber,et al.  Physical Principles of Medical Ultrasonics: Hill/Physical Principles of Medical Ultrasonics, Second Edition , 2005 .

[3]  S. Suresh,et al.  Measurement of Viscoelastic Properties of Polyacrylamide-Based Tissue-Mimicking Phantoms for Ultrasound Elastography Applications , 2010, IEEE Transactions on Instrumentation and Measurement.

[4]  P. Hoskins,et al.  Assessment of the acoustic properties of common tissue-mimicking test phantoms. , 2003, Ultrasound in medicine & biology.

[5]  G. Ludwig,et al.  The Velocity of Sound through Tissues and the Acoustic Impedance of Tissues , 1950 .

[6]  A M Hodge,et al.  Elastic and viscoelastic characterization of agar. , 2012, Journal of the mechanical behavior of biomedical materials.

[7]  G. Trahey,et al.  On the feasibility of remote palpation using acoustic radiation force. , 2001, The Journal of the Acoustical Society of America.

[8]  Gregg Trahey,et al.  Acoustic Radiation Force Impulse Imaging of In Vivo Vastus Medialis Muscle Under Varying Isometric Load , 2002, Ultrasonic imaging.

[9]  E. Madsen,et al.  Tissue mimicking materials for ultrasound phantoms. , 1978, Medical physics.

[10]  Gregg Trahey,et al.  Acoustic radiation force impulse imaging: in vivo demonstration of clinical feasibility. , 2002, Ultrasound in medicine & biology.

[11]  Gregg Trahey,et al.  Observations of Tissue Response to Acoustic Radiation Force: Opportunities for Imaging , 2002, Ultrasonic imaging.

[12]  J. Ophir,et al.  Elastography: A Quantitative Method for Imaging the Elasticity of Biological Tissues , 1991, Ultrasonic imaging.