Effect of rapamycin on aging and age-related diseases—past and future
暂无分享,去创建一个
[1] D. Leaf,et al. Post-sepsis immunosuppression depends on NKT cell regulation of mTOR/IFNγ in NK cells. , 2020, The Journal of clinical investigation.
[2] M. Blasco,et al. The mTOR pathway is necessary for survival of mice with short telomeres , 2020, Nature Communications.
[3] S. Austad,et al. Bring Back the Rat! , 2020, The journals of gerontology. Series A, Biological sciences and medical sciences.
[4] B. Everts,et al. Pathogens MenTORing Macrophages and Dendritic Cells: Manipulation of mTOR and Cellular Metabolism to Promote Immune Escape , 2020, Cells.
[5] Xiaodong Han,et al. Epithelial cell senescence induces pulmonary fibrosis through Nanog-mediated fibroblast activation , 2019, Aging.
[6] Gennifer E. Merrihew,et al. Rapamycin persistently improves cardiac function in aged, male and female mice, even following cessation of treatment , 2019, Aging cell.
[7] A. Lorenzini,et al. Topical rapamycin reduces markers of senescence and aging in human skin: an exploratory, prospective, randomized trial , 2019, GeroScience.
[8] Guorong Wu,et al. Melatonin and Rapamycin Attenuate Isoflurane-Induced Cognitive Impairment Through Inhibition of Neuroinflammation by Suppressing the mTOR Signaling in the Hippocampus of Aged Mice , 2019, Front. Aging Neurosci..
[9] S. Austad,et al. mTOR drives cerebrovascular, synaptic, and cognitive dysfunction in normative aging , 2019, Aging cell.
[10] M. Blagosklonny. Rapamycin for longevity: opinion article , 2019, Aging.
[11] Li-ping Chen,et al. Rapamycin relieves inflammation of experimental autoimmune encephalomyelitis by altering the balance of Treg/Th17 in a mouse model , 2019, Neuroscience Letters.
[12] Freddie H. Fu,et al. Rapamycin Rescues Age-Related Changes in Muscle-Derived Stem/Progenitor Cells from Progeroid Mice , 2019, Molecular therapy. Methods & clinical development.
[13] T. Sargeant,et al. Rapamycin and Alzheimer disease: a double-edged sword? , 2019, Autophagy.
[14] Dudley Lamming,et al. Next generation strategies for geroprotection via mTORC1 inhibition. , 2019, The journals of gerontology. Series A, Biological sciences and medical sciences.
[15] M. Kaeberlein,et al. Rapamycin and Alzheimer’s disease: Time for a clinical trial? , 2019, Science Translational Medicine.
[16] Eyal Amiel,et al. Regulation of Dendritic Cell Immune Function and Metabolism by Cellular Nutrient Sensor Mammalian Target of Rapamycin (mTOR) , 2019, Front. Immunol..
[17] Akira Yoshii,et al. Multiple Critical Periods for Rapamycin Treatment to Correct Structural Defects in Tsc-1-Suppressed Brain , 2018, Front. Mol. Neurosci..
[18] D. Butterfield,et al. Intranasal rapamycin ameliorates Alzheimer-like cognitive decline in a mouse model of Down syndrome , 2018, Translational Neurodegeneration.
[19] C. Ross,et al. Long‐term treatment with the mTOR inhibitor rapamycin has minor effect on clinical laboratory markers in middle‐aged marmosets , 2018, American journal of primatology.
[20] M. Beibel,et al. TORC1 inhibition enhances immune function and reduces infections in the elderly , 2018, Science Translational Medicine.
[21] J. Bielas,et al. Long term rapamycin treatment improves mitochondrial DNA quality in aging mice , 2018, Experimental Gerontology.
[22] Yizhen Chen,et al. [Neuroprotective effect of rapamycin against Parkinson's disease in mice]. , 2018, Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences.
[23] T. Curiel,et al. A randomized control trial to establish the feasibility and safety of rapamycin treatment in an older human cohort: Immunological, physical performance, and cognitive effects , 2018, Experimental Gerontology.
[24] G. Fisone,et al. Inhibition of mTORC1 Signaling Reverts Cognitive and Affective Deficits in a Mouse Model of Parkinson’s Disease , 2018, Front. Neurol..
[25] Z. Ungvari,et al. Inhibition of mTOR protects the blood-brain barrier in models of Alzheimer's disease and vascular cognitive impairment. , 2018, American journal of physiology. Heart and circulatory physiology.
[26] D. Harrison,et al. Cardioprotective effects of dietary rapamycin on adult female C57BLKS/J‐Leprdb mice , 2018, Annals of the New York Academy of Sciences.
[27] M. Hadamitzky,et al. Repeated Systemic Treatment with Rapamycin Affects Behavior and Amygdala Protein Expression in Rats , 2018, The international journal of neuropsychopharmacology.
[28] P. Validire,et al. mTOR pathway activation drives lung cell senescence and emphysema. , 2018, JCI insight.
[29] Jie Chen,et al. Effects of rapamycin on growth hormone receptor knockout mice , 2018, Proceedings of the National Academy of Sciences.
[30] Dong Zhou,et al. Rapamycin Protects Sepsis-Induced Cognitive Impairment in Mouse Hippocampus by Enhancing Autophagy , 2016, Cellular and Molecular Neurobiology.
[31] W. Swindell. Rapamycin in mice , 2017, Aging.
[32] Owen S. Skinner,et al. Low-dose rapamycin extends lifespan in a mouse model of mtDNA depletion syndrome , 2017, Human molecular genetics.
[33] Russell G. Jones,et al. MenTORing Immunity: mTOR Signaling in the Development and Function of Tissue-Resident Immune Cells. , 2017, Immunity.
[34] D. Promislow,et al. A randomized controlled trial to establish effects of short-term rapamycin treatment in 24 middle-aged companion dogs , 2017, GeroScience.
[35] E. Ho,et al. Rapamycin inhibits the secretory phenotype of senescent cells by a Nrf2‐independent mechanism , 2017, Aging cell.
[36] Anshi Wu,et al. Activation of mTOR signaling leads to orthopedic surgery-induced cognitive decline in mice through β-amyloid accumulation and tau phosphorylation. , 2016, Molecular medicine reports.
[37] D. Seals,et al. Dietary rapamycin supplementation reverses age‐related vascular dysfunction and oxidative stress, while modulating nutrient‐sensing, cell cycle, and senescence pathways , 2016, Aging cell.
[38] Wei Zhang,et al. Neuroprotective Effects of Salidroside in the MPTP Mouse Model of Parkinson's Disease: Involvement of the PI3K/Akt/GSK3β Pathway , 2016, Parkinson's disease.
[39] Jinhui Chen,et al. Traumatic Brain Injury Stimulates Neural Stem Cell Proliferation via Mammalian Target of Rapamycin Signaling Pathway Activation , 2016, eNeuro.
[40] Kathleen F. Kerr,et al. Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice , 2016, eLife.
[41] Bethany Halford,et al. Rapamycin’s secrets unearthed , 2016 .
[42] D. Féliers,et al. Rapamycin Increases Mortality in db/db Mice, a Mouse Model of Type 2 Diabetes. , 2016, The journals of gerontology. Series A, Biological sciences and medical sciences.
[43] S. A. Arriola Apelo,et al. Rapamycin: An InhibiTOR of Aging Emerges From the Soil of Easter Island. , 2016, The journals of gerontology. Series A, Biological sciences and medical sciences.
[44] Dudley Lamming,et al. Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an α‐glucosidase inhibitor or a Nrf2‐inducer , 2016, Aging cell.
[45] P. Cortelli,et al. Rotigotine Objectively Improves Sleep in Parkinson's Disease: An Open-Label Pilot Study with Actigraphic Recording , 2016, Parkinson's disease.
[46] Wei Zhang,et al. Rapamycin rescues vascular, metabolic and learning deficits in apolipoprotein E4 transgenic mice with pre-symptomatic Alzheimer’s disease , 2015, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
[47] R. Siman,et al. The mTOR Inhibitor Rapamycin Mitigates Perforant Pathway Neurodegeneration and Synapse Loss in a Mouse Model of Early-Stage Alzheimer-Type Tauopathy , 2015, PloS one.
[48] S. Tardif,et al. Metabolic consequences of long-term rapamycin exposure on common marmoset monkeys (Callithrix jacchus) , 2015, Aging.
[49] T. Weichhart,et al. Regulation of innate immune cell function by mTOR , 2015, Nature Reviews Immunology.
[50] Randy Strong,et al. NIA Interventions Testing Program: Investigating Putative Aging Intervention Agents in a Genetically Heterogeneous Mouse Model , 2015, EBioMedicine.
[51] T. Curiel,et al. Chronic mTOR inhibition in mice with rapamycin alters T, B, myeloid, and innate lymphoid cells and gut flora and prolongs life of immune‐deficient mice , 2015, Aging cell.
[52] L. Zender,et al. mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype , 2015, Nature Cell Biology.
[53] A. Richardson,et al. How longevity research can lead to therapies for Alzheimer's disease: The rapamycin story , 2015, Experimental Gerontology.
[54] P. Rabinovitch,et al. Dose-dependent effects of mTOR inhibition on weight and mitochondrial disease in mice , 2015, Front. Genet..
[55] P. Nelson,et al. MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation , 2015, Nature Cell Biology.
[56] C. Livi,et al. p53 and rapamycin are additive , 2015, Oncotarget.
[57] S. Krähenbühl,et al. Acute Sirolimus Overdose: A Multicenter Case Series , 2015, PloS one.
[58] A. Bokov,et al. Rapamycin improves motor function, reduces 4-hydroxynonenal adducted protein in brain, and attenuates synaptic injury in a mouse model of synucleinopathy , 2015, Pathobiology of aging & age related diseases.
[59] J. Praestgaard,et al. mTOR inhibition improves immune function in the elderly , 2014, Science Translational Medicine.
[60] L. Tan,et al. Upregulation of TREM2 Ameliorates Neuropathology and Rescues Spatial Cognitive Impairment in a Transgenic Mouse Model of Alzheimer’s Disease , 2014, Neuropsychopharmacology.
[61] K. Limesand,et al. Lifespan-extending caloric restriction or mTOR inhibition impair adaptive immunity of old mice by distinct mechanisms , 2014, Aging cell.
[62] M. Hadamitzky,et al. Acute systemic rapamycin induces neurobehavioral alterations in rats , 2014, Behavioural Brain Research.
[63] M. Smithey,et al. Immune Memory–Boosting Dose of Rapamycin Impairs Macrophage Vesicle Acidification and Curtails Glycolysis in Effector CD8 Cells, Impairing Defense against Acute Infections , 2014, The Journal of Immunology.
[64] F. Neff,et al. Longevity, aging and rapamycin , 2014, Cellular and Molecular Life Sciences.
[65] B. Kaplan,et al. Strategies for the management of adverse events associated with mTOR inhibitors. , 2014, Transplantation reviews.
[66] X. Chen,et al. Rapamycin Attenuated Cardiac Hypertrophy Induced by Isoproterenol and Maintained Energy Homeostasis via Inhibiting NF-κB Activation , 2014, Mediators of inflammation.
[67] M. MacCoss,et al. Altered proteome turnover and remodeling by short-term caloric restriction or rapamycin rejuvenate the aging heart , 2014, Aging cell.
[68] V. Anisimov,et al. Lifespan extension and cancer prevention in HER-2/neu transgenic mice treated with low intermittent doses of rapamycin , 2014, Cancer biology & therapy.
[69] Z. D. Sharp,et al. Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction , 2014, Aging cell.
[70] S. Austad,et al. Rapamycin extends life and health in C57BL/6 mice. , 2014, The journals of gerontology. Series A, Biological sciences and medical sciences.
[71] W. Wood,et al. Mice Fed Rapamycin Have an Increase in Lifespan Associated with Major Changes in the Liver Transcriptome , 2014, PloS one.
[72] M. Antoch,et al. BMAL1-dependent regulation of the mTOR signaling pathway delays aging , 2014, Aging.
[73] H. Remmen,et al. Reduced mammalian target of rapamycin activity facilitates mitochondrial retrograde signaling and increases life span in normal human fibroblasts , 2013, Aging cell.
[74] C. Livi,et al. eRapa Restores a Normal Life Span in a FAP Mouse Model , 2013, Cancer Prevention Research.
[75] R. Day,et al. Inhibition of IGF-1R Prevents Ionizing Radiation-Induced Primary Endothelial Cell Senescence , 2013, PloS one.
[76] Maureen A. McGargill,et al. mTOR modulates the antibody response to provide cross-protective immunity to lethal influenza infections , 2013, Nature Immunology.
[77] B. Kennedy,et al. Late‐life rapamycin treatment reverses age‐related heart dysfunction , 2013, Aging cell.
[78] H. Fuchs,et al. Rapamycin extends murine lifespan but has limited effects on aging. , 2013, The Journal of clinical investigation.
[79] P. Fox,et al. Chronic Rapamycin Restores Brain Vascular Integrity and Function Through NO Synthase Activation and Improves Memory in Symptomatic Mice Modeling Alzheimer’s Disease , 2013, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
[80] L. Kappos,et al. Rapamycin Attenuates the Progression of Tau Pathology in P301S Tau Transgenic Mice , 2013, PloS one.
[81] Pasko Rakic,et al. A Transgenic Alzheimer Rat with Plaques, Tau Pathology, Behavioral Impairment, Oligomeric Aβ, and Frank Neuronal Loss , 2013, The Journal of Neuroscience.
[82] L. Leocani,et al. Behavioural and EEG effects of chronic rapamycin treatment in a mouse model of Tuberous Sclerosis Complex , 2013, Neuropharmacology.
[83] A. Anderson,et al. Rapamycin Reverses Status Epilepticus-Induced Memory Deficits and Dendritic Damage , 2013, PloS one.
[84] J. Campisi,et al. Cellular senescence and the senescent secretory phenotype: therapeutic opportunities. , 2013, The Journal of clinical investigation.
[85] Alcino J. Silva,et al. mTOR Inhibition Ameliorates Cognitive and Affective Deficits Caused by Disc1 Knockdown in Adult-Born Dentate Granule Neurons , 2013, Neuron.
[86] C. Soto,et al. Smoking exacerbates amyloid pathology in a mouse model of Alzheimer’s disease , 2013, Nature Communications.
[87] Ariel Orellana,et al. Correction: Corrigendum: ER-localized auxin transporter PIN8 regulates auxin homoeostasis and male gametophyte development in Arabidopsis , 2013, Nature Communications.
[88] C. Livi,et al. Rapamycin extends life span of Rb1+/− mice by inhibiting neuroendocrine tumors , 2013, Aging.
[89] Huaxi Xu,et al. Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy , 2013, Nature Reviews Neurology.
[90] P. Rabinovitch,et al. mTOR is a key modulator of ageing and age-related disease , 2013, Nature.
[91] K. Vousden,et al. p53 mutations in cancer , 2013, Nature Cell Biology.
[92] S. Austad,et al. Enteric-delivered rapamycin enhances resistance of aged mice to pneumococcal pneumonia through reduced cellular senescence , 2012, Experimental Gerontology.
[93] S. Austad,et al. Chronic inhibition of mammalian target of rapamycin by rapamycin modulates cognitive and non-cognitive components of behavior throughout lifespan in mice , 2012, Neuroscience.
[94] M. Antoch,et al. Rapamycin extends lifespan and delays tumorigenesis in heterozygous p53+/− mice , 2012, Aging.
[95] M. Antoch,et al. New nanoformulation of rapamycin Rapatar extends lifespan in homozygous p53−/− mice by delaying carcinogenesis , 2012, Aging.
[96] F. Gruijl,et al. Rapamycin impairs UV induction of mutant‐p53 overexpressing cell clusters without affecting tumor onset , 2012, International journal of cancer.
[97] James B. Mitchell,et al. mTOR inhibition prevents epithelial stem cell senescence and protects from radiation-induced mucositis. , 2012, Cell stem cell.
[98] Michael G. Garelick,et al. Rapamycin Reverses Elevated mTORC1 Signaling in Lamin A/C–Deficient Mice, Rescues Cardiac and Skeletal Muscle Function, and Extends Survival , 2012, Science Translational Medicine.
[99] Jacqueline N. Crawley,et al. Autistic-like behavior and cerebellar dysfunction in Purkinje cell Tsc1 mutant mice , 2012, Nature.
[100] T. V. Bykova,et al. Suppression of replicative senescence by rapamycin in rodent embryonic cells , 2012, Cell cycle.
[101] Xueyuan Bai,et al. SIRT1 is required for the effects of rapamycin on high glucose-inducing mesangial cells senescence , 2012, Mechanisms of Ageing and Development.
[102] M. Bouchard,et al. Inhibition of Mammalian Target of Rapamycin Augments Lipopolysaccharide-Induced Lung Injury and Apoptosis , 2012, The Journal of Immunology.
[103] A. Caccamo,et al. Lifelong rapamycin administration ameliorates age‐dependent cognitive deficits by reducing IL‐1β and enhancing NMDA signaling , 2012, Aging cell.
[104] K. Seung,et al. Randomized comparison of the efficacy and safety of zotarolimus-eluting stents vs. sirolimus-eluting stents for percutaneous coronary intervention in chronic total occlusion--CAtholic Total Occlusion Study (CATOS) trial. , 2012, Circulation journal : official journal of the Japanese Circulation Society.
[105] S. Hursting,et al. Calorie restriction and rapamycin inhibit MMTV-Wnt-1 mammary tumor growth in a mouse model of postmenopausal obesity. , 2012, Endocrine-related cancer.
[106] S. Komarova,et al. Rapamycin inhibits osteolysis and improves survival in a model of experimental bone metastases. , 2012, Cancer letters.
[107] Richie Soong,et al. Pharmacologic synergy between dual phosphoinositide-3-kinase and mammalian target of rapamycin inhibition and 5-Fluorouracil in PIK3CA mutant gastric cancer cells , 2012, Cancer biology & therapy.
[108] A. Gudkov,et al. Elimination of Proliferating Cells Unmasks the Shift from Senescence to Quiescence Caused by Rapamycin , 2011, PloS one.
[109] Smita Majumder,et al. Inducing Autophagy by Rapamycin Before, but Not After, the Formation of Plaques and Tangles Ameliorates Cognitive Deficits , 2011, Alzheimer's & Dementia.
[110] S. Toyooka,et al. Inhibition of mTOR by temsirolimus contributes to prolonged survival of mice with pleural dissemination of non‐small‐cell lung cancer cells , 2011, Cancer science.
[111] Francis S Collins,et al. Rapamycin Reverses Cellular Phenotypes and Enhances Mutant Protein Clearance in Hutchinson-Gilford Progeria Syndrome Cells , 2011, Science Translational Medicine.
[112] M. Mita,et al. Are we ready to move away from nature? The rapamycin story , 2011, Targeted Oncology.
[113] S. Fischer,et al. Rapamycin Partially Mimics the Anticancer Effects of Calorie Restriction in a Murine Model of Pancreatic Cancer , 2011, Cancer Prevention Research.
[114] B. Ghanim,et al. Temsirolimus Inhibits Malignant Pleural Mesothelioma Growth In Vitro and In Vivo: Synergism with Chemotherapy , 2011, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.
[115] M. Mita,et al. The emerging role of mammalian target of rapamycin inhibitors in the treatment of sarcomas , 2011, Targeted Oncology.
[116] A. Brenner,et al. Common toxicities of mammalian target of rapamycin inhibitors , 2011, Targeted Oncology.
[117] T. Clackson,et al. Ridaforolimus (AP23573; MK-8669), a Potent mTOR Inhibitor, Has Broad Antitumor Activity and Can Be Optimally Administered Using Intermittent Dosing Regimens , 2011, Molecular Cancer Therapeutics.
[118] Liang Li,et al. Rapamycin treatment augments motor neuron degeneration in SOD1G93A mouse model of amyotrophic lateral sclerosis , 2011, Autophagy.
[119] B. Neel,et al. Rapamycin reverses hypertrophic cardiomyopathy in a mouse model of LEOPARD syndrome-associated PTPN11 mutation. , 2011, The Journal of clinical investigation.
[120] S. Kozma,et al. Selective pharmacogenetic inhibition of mammalian target of Rapamycin complex I (mTORC1) blocks long-term synaptic plasticity and memory storage , 2011, Proceedings of the National Academy of Sciences.
[121] R. de Cabo,et al. Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice. , 2011, The journals of gerontology. Series A, Biological sciences and medical sciences.
[122] H. Pitot,et al. Rapamycin Inhibits Anal Carcinogenesis in Two Preclinical Animal Models , 2010, Cancer Prevention Research.
[123] A. Kirk,et al. Cutting Edge: Rapamycin Augments Pathogen-Specific but Not Graft-Reactive CD8+ T Cell Responses , 2010, The Journal of Immunology.
[124] S. Oddo. Molecular interplay between mTOR, Aβ and tau: Effects on cognitive impairments , 2010, Alzheimer's & Dementia.
[125] J. Viña,et al. Why women have more Alzheimer's disease than men: gender and mitochondrial toxicity of amyloid-beta peptide. , 2010, Journal of Alzheimer's disease : JAD.
[126] C. Ching,et al. Mammalian target of rapamycin (mTOR) regulates cellular proliferation and tumor growth in urothelial carcinoma. , 2010, The American journal of pathology.
[127] M. Antoch,et al. Rapamycin extends maximal lifespan in cancer-prone mice. , 2010, The American journal of pathology.
[128] Arlan Richardson,et al. Molecular interplay between mammalian target of rapamycin (mTOR), amyloid-beta, and Tau: effects on cognitive impairments. , 2010, The Journal of biological chemistry.
[129] Jayanta Debnath,et al. Inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-β Levels in a Mouse Model of Alzheimer's Disease , 2010, PloS one.
[130] G. Koehl,et al. Rapamycin inhibits oncogenic intestinal ion channels and neoplasia in APCMin/+ mice , 2010, Oncogene.
[131] Lloyd A Greene,et al. Rapamycin Protects against Neuron Death in In Vitro andIn Vivo Models of Parkinson's Disease , 2010, The Journal of Neuroscience.
[132] H. Katus,et al. Beneficial effects of Mammalian target of rapamycin inhibition on left ventricular remodeling after myocardial infarction. , 2009, Journal of the American College of Cardiology.
[133] R. Abraham,et al. Targeting mTOR globally in cancer: Thinking beyond rapamycin , 2009, Cell cycle.
[134] Yang Liu,et al. mTOR Regulation and Therapeutic Rejuvenation of Aging Hematopoietic Stem Cells , 2009, Science Signaling.
[135] Youming Peng,et al. Expression and mechanism of mammalian target of rapamycin in age-related renal cell senescence and organ aging , 2009, Mechanisms of Ageing and Development.
[136] L. Chodosh,et al. mTOR mediates Wnt-induced epidermal stem cell exhaustion and aging. , 2009, Cell stem cell.
[137] R. Maldonado,et al. Cannabinoid modulation of hippocampal long-term memory is mediated by mTOR signaling , 2009, Nature Neuroscience.
[138] Marco Pahor,et al. Rapamycin fed late in life extends lifespan in genetically heterogeneous mice , 2009, Nature.
[139] B. Winblad,et al. Cognitive impairment in the Tg6590 transgenic rat model of Alzheimer’s disease , 2009, Journal of cellular and molecular medicine.
[140] M. Blagosklonny,et al. Rapamycin decelerates cellular senescence , 2009, Cell cycle.
[141] R. Ahmed,et al. mTOR regulates memory CD8 T cell differentiation , 2009, Nature.
[142] A. Sabichi,et al. Effects of mTOR Inhibitor Everolimus (RAD001) on Bladder Cancer Cells , 2009, Clinical Cancer Research.
[143] R. Hunter,et al. Autophagy enhances the efficacy of BCG vaccine by increasing peptide presentation in mouse dendritic cells , 2009, Nature Medicine.
[144] D. Dobrota,et al. Rat tau proteome consists of six tau isoforms: implication for animal models of human tauopathies , 2009, Journal of neurochemistry.
[145] D. Praticò,et al. Low‐dose oral sirolimus reduces atherogenesis, vascular inflammation and modulates plaque composition in mice lacking the LDL receptor , 2009, British journal of pharmacology.
[146] E. Abraham,et al. Participation of mammalian target of rapamycin complex 1 in Toll-like receptor 2- and 4-induced neutrophil activation and acute lung injury. , 2009, American journal of respiratory cell and molecular biology.
[147] Judith Campisi,et al. Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor , 2008, PLoS biology.
[148] K. Stuhlmeier,et al. The TSC-mTOR signaling pathway regulates the innate inflammatory response. , 2008, Immunity.
[149] H. Lane,et al. Inhibition of the mTORC1 pathway suppresses intestinal polyp formation and reduces mortality in ApcΔ716 mice , 2008, Proceedings of the National Academy of Sciences.
[150] Alcino J. Silva,et al. Reversal of learning deficits in a Tsc2+/− mouse model of tuberous sclerosis , 2008, Nature Medicine.
[151] A. Goldfarb-Rumyantzev,et al. Diabetes after transplantation and sirolimus: what's the connection? , 2008, Journal of the American Society of Nephrology : JASN.
[152] T. Münzel,et al. Sirolimus-induced vascular dysfunction. Increased mitochondrial and nicotinamide adenosine dinucleotide phosphate oxidase-dependent superoxide production and decreased vascular nitric oxide formation. , 2008, Journal of the American College of Cardiology.
[153] D. Teupser,et al. Prevention of atherosclerosis by the mTOR inhibitor everolimus in LDLR-/- mice despite severe hypercholesterolemia. , 2008, Atherosclerosis.
[154] A. Tolkovsky,et al. Rapamycin Inhibits Polyglutamine Aggregation Independently of Autophagy by Reducing Protein Synthesis , 2008, Molecular Pharmacology.
[155] E. Cohen. mTOR: the mammalian target of replication. , 2008, Journal of Clinical Oncology.
[156] P. Pandolfi,et al. The AKT-mTOR pathway plays a critical role in the development of leiomyosarcomas , 2007, Nature Medicine.
[157] A. Abizaid. Sirolimus-eluting coronary stents: a review , 2007, Vascular health and risk management.
[158] K. Maekawa,et al. Impaired endothelial vasomotor function after sirolimus-eluting stent implantation. , 2007, Circulation journal : official journal of the Japanese Circulation Society.
[159] T. Akasaka,et al. Sirolimus accelerates senescence of endothelial progenitor cells through telomerase inactivation. , 2006, Atherosclerosis.
[160] A. Dart,et al. Inhibition of mTOR reduces chronic pressure-overload cardiac hypertrophy and fibrosis , 2006, Journal of hypertension.
[161] D. Rubinsztein,et al. Rapamycin alleviates toxicity of different aggregate-prone proteins. , 2006, Human molecular genetics.
[162] Matt Kaeberlein,et al. Extension of chronological life span in yeast by decreased TOR pathway signaling. , 2006, Genes & development.
[163] Matt Kaeberlein,et al. Regulation of Yeast Replicative Life Span by TOR and Sch9 in Response to Nutrients , 2005, Science.
[164] David L. Williams,et al. Reduced cardiac hypertrophy in toll-like receptor 4-deficient mice following pressure overload. , 2005, Cardiovascular research.
[165] R. Pakala,et al. Rapamycin Attenuates Atherosclerotic Plaque Progression in Apolipoprotein E Knockout Mice: Inhibitory Effect on Monocyte Chemotaxis , 2005, Journal of cardiovascular pharmacology.
[166] J. Shay,et al. Senescence and immortalization: role of telomeres and telomerase. , 2005, Carcinogenesis.
[167] Peter T. Lansbury,et al. Impaired Degradation of Mutant α-Synuclein by Chaperone-Mediated Autophagy , 2004, Science.
[168] M. Boluyt,et al. The mTOR/p70S6K Signal Transduction Pathway Plays a Role in Cardiac Hypertrophy and Influences Expression of Myosin Heavy Chain Genes in vivo , 2004, Cardiovascular Drugs and Therapy.
[169] S. Izumo,et al. Inhibition of mTOR Signaling With Rapamycin Regresses Established Cardiac Hypertrophy Induced by Pressure Overload , 2004, Circulation.
[170] S. Benzer,et al. Regulation of Lifespan in Drosophila by Modulation of Genes in the TOR Signaling Pathway , 2004, Current Biology.
[171] S. Benzer,et al. Regulation of Lifespan in Drosophila by Modulation of Genes in the TOR Signaling Pathway , 2004, Current Biology.
[172] Francesco Scaravilli,et al. Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease , 2004, Nature Genetics.
[173] Tibor Vellai,et al. Genetics: Influence of TOR kinase on lifespan in C. elegans , 2003, Nature.
[174] K. Mansfield,et al. Marmoset models commonly used in biomedical research. , 2003, Comparative medicine.
[175] W. Manning,et al. Rapamycin Attenuates Load-Induced Cardiac Hypertrophy in Mice , 2003, Circulation.
[176] C. Ballantyne,et al. Effects of sirolimus on plasma lipids, lipoprotein levels, and fatty acid metabolism in renal transplant patients DOI 10.1194/jlr.M100392-JLR200 , 2002, Journal of Lipid Research.
[177] C. Groth,et al. Pharmacokinetics and Safety of Single Oral Doses of Sirolimus (Rapamycin) in Healthy Male Volunteers , 2000, Therapeutic drug monitoring.
[178] V. Berlin,et al. RAPT1, a mammalian homolog of yeast Tor, interacts with the FKBP12/rapamycin complex. , 1994, Proceedings of the National Academy of Sciences of the United States of America.
[179] Paul Tempst,et al. RAFT1: A mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs , 1994, Cell.
[180] Stuart L. Schreiber,et al. A mammalian protein targeted by G1-arresting rapamycin–receptor complex , 1994, Nature.
[181] J. Heitman,et al. Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast , 1991, Science.
[182] L. Hayflick,et al. The serial cultivation of human diploid cell strains. , 1961, Experimental cell research.
[183] M. Javors,et al. mTOR drives cerebral blood flow and memory deficits in LDLR−/− mice modeling atherosclerosis and vascular cognitive impairment , 2018, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
[184] C. Geula,et al. Amyloid-β deposits in the cerebral cortex of the aged common marmoset (Callithrix jacchus): incidence and chemical composition , 2014, Acta Neuropathologica.
[185] B. Hemmings,et al. S6K inhibition renders cardiac protection against myocardial infarction through PDK1 phosphorylation of Akt. , 2012, The Biochemical journal.
[186] Leonidas Stefanis,et al. Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy. , 2004, Science.