Double-stranded RNA viruses of Saccharomyces cerevisiae

INFECTIOUS ELEMENTS OF SACCHAROMYCES CEREVISIAE ....................................................................250 BIOLOGY OF THE YEAST dsRNA VIRUSES AND THE KILLER PHENOMENON...................................250 L-A VIRUS STRUCTURE: T 5 1 WITH 60 ASYMMETRIC Gag DIMERS.....................................................251 VIRAL REPLICATION CYCLES.............................................................................................................................251 L-A ENCODES Gag AND Gag-Pol ..........................................................................................................................252 REPLICATION AND TRANSCRIPTION OF VIRAL RNA: IN VITRO SYSTEMS.........................................254 TRANSLATION OF VIRAL mRNA .........................................................................................................................254 The SKI2,3,8 System Blocks the Translation of Non-Poly(A) mRNA .............................................................255 M1 Propagation Depends Critically on Free 60S Ribosomal Subunit Levels................................................256 Do SKI2, 3, and 8 Determine 60S Subunit Interaction with Poly(A)?............................................................257 Gag Makes Decapitated Decoys To Distract the SKI1/XRN1 Exoribonuclease..............................................257 Lethality of ski1 ski2 and ski1 ski3 double mutants.......................................................................................258 Gag-Pol Fusion Protein Formed by a 21 Ribosomal Frameshift: How and Why ........................................258 Mechanism of 21 ribosomal frameshifting ....................................................................................................258 How critical is the efficiency of frameshifting?...............................................................................................259 Chromosomal genes affecting the efficiency of frameshifting.......................................................................259 Can 21 ribosomal frameshifting be used as a target of antiviral drugs? .................................................259 POSTTRANSLATIONAL PROCESSING ...............................................................................................................259 MAK3 N-Acetyltransferase Modification of Gag Is Necessary for Assembly .................................................259 Killer Preprotoxin Is Processed To Form Mature Toxin..................................................................................260 KEX1 and KEX2 Processing Proteases and Mammalian Prohormone Processing........................................260 RNA PACKAGING: IN VITRO AND IN VIVO......................................................................................................260 Evidence for cis Packaging by L-A .......................................................................................................................260 Does Packaging Control Translation? .................................................................................................................260 L-BC IS CLOSELY RELATED TO L-A..................................................................................................................261 CONCLUSIONS AND PROSPECTS.......................................................................................................................261 REFERENCES ............................................................................................................................................................262

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