Supraventricular tachyarrhythmias. Treatment with edrophonium.

Twelve of 16 (75%) supraventricular tachycardias were abruptly terminated by intravenously administered edrophonium chloride (Tensilon) in doses ranging from 5 to 20 mg. Transient side effects of the drug were seen in five patients (31.3%) and subsided spontaneously as the drug effect was rapidly dissipated. The experience of other investigators is reviewed and the mechanism of drug action is discussed. Despite little recognition to date as an antiarrhythmic agent, edrophonium may prove to be the initial drug treatment of choice in managing a variety of supraventricular tachyarrhythmias.

[1]  J. Parker,et al.  Temporal Relationships of Myocardial Lactate Metabolism, Left Ventricular Function, and S‐T Segment Depression During Angina Precipitated by Exercise , 1969, Circulation.

[2]  J. Moyer,et al.  USE OF EDROPHONIUM (TENSILON) IN THE EVALUATION OF SUPRAVENTRICULAR TACHYCARDIA , 1967, The American journal of the medical sciences.

[3]  A. Unger,et al.  Fatalities following intravenous use of sodium diphenylhydantoin for cardiac arrhythmias. Report of two cases. , 1967, JAMA.

[4]  C. Martínez,et al.  Fatal ventricular fibrillation following intravenous sodium diphenylhydantoin therapy. , 1967, JAMA.

[5]  B. Pitt,et al.  Use of edrophonium chloride (tensilon) to detect early digitalis toxicity. , 1966, The American journal of cardiology.

[6]  S. Stephen.  Unwanted effects of propranolol. , 1966, The American journal of cardiology.

[7]  A. Moss,et al.  Use of edrophonium (tensilon) in the evaluation of supraventricular tachycardias. , 1966, The American journal of cardiology.

[8]  R. Greenwood,et al.  Death following carotid sinus pressure. , 1962, JAMA.

[9]  B. Lown,et al.  The Carotid Sinus: Clinical Value of Its Stimulation , 1961, Circulation.

[10]  L. O. Randall.  SYNTHETIC CURARE‐LIKE AGENTS AND THEIR ANTAGONISTS , 1951, Annals of the New York Academy of Sciences.

[11]  E. S. Brannon.  Hemiplegia following carotid sinus stimulation; a case report. , 1948, American Heart Journal.

[12]  F. D. Zeman,et al.  MONOPLEGIA FOLLOWING CAROTID SINUS PRESSURE IN THE AGED , 1947, The American journal of the medical sciences.