The role of prefrontal cortex and posterior parietal cortex in task switching.

Human ability to switch from one cognitive task to another involves both endogenous preparation without an external stimulus and exogenous adjustment in response to the external stimulus. In an event-related functional MRI study, participants performed pairs of two tasks that are either the same (task repetition) or different (task switch) from each other. On half of the trials, foreknowledge about task repetition or task switch was available. On the other half, it was not. Endogenous preparation seems to involve lateral prefrontal cortex (BA 46/45) and posterior parietal cortex (BA 40). During preparation, higher activation increases in inferior lateral prefrontal cortex and superior posterior parietal cortex were associated with foreknowledge than with no foreknowledge. Exogenous adjustment seems to involve superior prefrontal cortex (BA 8) and posterior parietal cortex (BA 39/40) in general. During a task switch with no foreknowledge, activations in these areas were relatively higher than during a task repetition with no foreknowledge. These results suggest that endogenous preparation and exogenous adjustment for a task switch may be independent processes involving different brain areas.

[1]  Eliot Slater.  Psychobiology , 1949 .

[2]  P. Goldman-Rakic.  Topography of cognition: parallel distributed networks in primate association cortex. , 1988, Annual review of neuroscience.

[3]  G. Ratcliff,et al.  The disengagement of covert attention and the neglect syndrome , 1988, Psychobiology.

[4]  J. Talairach,et al.  Co-Planar Stereotaxic Atlas of the Human Brain: 3-Dimensional Proportional System: An Approach to Cerebral Imaging , 1988 .

[5]  T. Robbins,et al.  Contrasting mechanisms of impaired attentional set-shifting in patients with frontal lobe damage or Parkinson's disease. , 1993, Brain : a journal of neurology.

[6]  Arthur F. Kramer,et al.  Strategies and automaticity. I: Basic findings and conceptual framework , 1994 .

[7]  S. Monsell,et al.  Costs of a predictible switch between simple cognitive tasks. , 1995 .

[8]  N. Meiran.  Reconfiguration of processing mode prior to task performance. , 1996 .

[9]  Edward E. Smith,et al.  Temporal dynamics of brain activation during a working memory task , 1997, Nature.

[10]  C. Lebiere,et al.  The Atomic Components of Thought , 1998 .

[11]  Scott T. Grafton,et al.  Automated image registration: I. General methods and intrasubject, intramodality validation. , 1998, Journal of computer assisted tomography.

[12]  Y. Miyashita,et al.  Transient activation of inferior prefrontal cortex during cognitive set shifting , 1998, Nature Neuroscience.

[13]  Leslie G. Ungerleider,et al.  An area specialized for spatial working memory in human frontal cortex. , 1998, Science.

[14]  M. Corbetta,et al.  Voluntary orienting is dissociated from target detection in human posterior parietal cortex , 2000, Nature Neuroscience.

[15]  J. Cohen,et al.  Dissociating the role of the dorsolateral prefrontal and anterior cingulate cortex in cognitive control. , 2000, Science.

[16]  E. Koechlin,et al.  Dissociating the role of the medial and lateral anterior prefrontal cortex in human planning. , 2000, Proceedings of the National Academy of Sciences of the United States of America.