Tamoxifen acts on Trypanosoma cruzi sphingolipid pathway triggering an apoptotic death process.

[1]  A. Silber,et al.  Tamoxifen inhibits the biosynthesis of inositolphosphorylceramide in Leishmania , 2018, International journal for parasitology. Drugs and drug resistance.

[2]  V. Duschak Targets and Patented Drugs for Chemotherapy of Chagas Disease in the Last 15 Years-Period. , 2016, Recent patents on anti-infective drug discovery.

[3]  Cristiana T. Trinconi,et al.  Efficacy of tamoxifen and miltefosine combined therapy for cutaneous leishmaniasis in the murine model of infection with Leishmania amazonensis. , 2016, The Journal of antimicrobial chemotherapy.

[4]  L. Agredano-Moreno,et al.  Ultrastructural and physiological changes induced by different stress conditions on the human parasite Trypanosoma cruzi , 2016, Cell Stress and Chaperones.

[5]  Cristiana T. Trinconi,et al.  Leishmania is not prone to develop resistance to tamoxifen , 2015, International journal for parasitology. Drugs and drug resistance.

[6]  Chunfa Huang,et al.  Lipid Metabolism, Apoptosis and Cancer Therapy , 2015, International journal of molecular sciences.

[7]  Cristiana T. Trinconi,et al.  Combination Therapy with Tamoxifen and Amphotericin B in Experimental Cutaneous Leishmaniasis , 2014, Antimicrobial Agents and Chemotherapy.

[8]  T. Urményi,et al.  Molecular and functional characterization of the ceramide synthase from Trypanosoma cruzi. , 2012, Molecular and biochemical parasitology.

[9]  R. Docampo,et al.  Inositolphosphoceramide Metabolism in Trypanosoma cruzi as Compared with other Trypanosomatids , 2011, The Journal of eukaryotic microbiology.

[10]  P. Bastien,et al.  Targeting essential pathways in trypanosomatids gives insights into protozoan mechanisms of cell death , 2010, Parasites & Vectors.

[11]  D. C. Miguel,et al.  The anticancer drug tamoxifen is active against Trypanosoma cruzi in vitro but ineffective in the treatment of the acute phase of Chagas disease in mice. , 2010, Memorias do Instituto Oswaldo Cruz.

[12]  Renata L. S. Goncalves,et al.  The effects on Trypanosoma cruzi of novel synthetic naphthoquinones are mediated by mitochondrial dysfunction. , 2009, Free radical biology & medicine.

[13]  W. de Souza,et al.  Subcellular proteomics of Trypanosoma cruzi reservosomes , 2009, Proteomics.

[14]  A. Vercesi,et al.  Mitochondrial calcium overload triggers complement-dependent superoxide-mediated programmed cell death in Trypanosoma cruzi. , 2009, The Biochemical journal.

[15]  N. Galanti,et al.  Natural programmed cell death in T. cruzi epimastigotes maintained in axenic cultures , 2008, Journal of cellular biochemistry.

[16]  D. C. Miguel,et al.  Tamoxifen Is Effective in the Treatment of Leishmania amazonensis Infections in Mice , 2008, PLoS neglected tropical diseases.

[17]  M. J. Soares,et al.  Mitochondrial disruption and DNA fragmentation in Trypanosoma cruzi induced by naphthoimidazoles synthesized from β-lapachone , 2007, Parasitology Research.

[18]  F. Hsu,et al.  Leishmania salvage and remodelling of host sphingolipids in amastigote survival and acidocalcisome biogenesis , 2005, Molecular microbiology.

[19]  B. Zingales,et al.  Trypanosoma cruzi: metabolic labeling of trypomastigote sialoglycolipids , 1985, Experientia.

[20]  E. F. Merino,et al.  Glycosphingolipids in Plasmodium falciparum. Presence of an active glucosylceramide synthase. , 2004, European journal of biochemistry.

[21]  S. Mandlekar,et al.  Mechanisms of tamoxifen-induced apoptosis , 2001, Apoptosis.

[22]  A. Ruiz,et al.  Trypanosoma cruzi: methoprene is a potent agent to sterilize blood infected with trypomastigotes. , 2002, Experimental parasitology.

[23]  G. Pohlentz,et al.  Monohexosylceramides of Trypanosoma dionisii. , 1996, The Journal of eukaryotic microbiology.

[24]  R. A. Klein,et al.  Structural characterization of neutral glycosphingolipids from Trypanosoma cruzi. , 1992, Molecular and biochemical parasitology.

[25]  J. Cazzulo,et al.  End products and enzyme levels of aerobic glucose fermentation in trypanosomatids. , 1985, Molecular and biochemical parasitology.

[26]  L. Hogge,et al.  Glycolipid components of epimastigote forms of Trypanosoma cruzi. , 1985, Comparative biochemistry and physiology. B, Comparative biochemistry.

[27]  B. Zingales,et al.  In vivo incorporation of palmitic acid and galactose in glycolipids of Trypanosoma cruzi epimastigotes. , 1985, Biochemistry international.

[28]  J. G. Hirsch,et al.  ULTRASTRUCTURE OF HUMAN LEUKOCYTES AFTER SIMULTANEOUS FIXATION WITH GLUTARALDEHYDE AND OSMIUM TETROXIDE AND "POSTFIXATION" IN URANYL ACETATE , 1968, Journal of Cell Biology.

[29]  Z. Brener Therapeutic activity and criterion of cure on mice experimentally infected with Trypanosoma cruzi. , 1962, Revista do Instituto de Medicina Tropical de Sao Paulo.