Psychiatric disorders in the relatives of probands with affective disorders. The Yale University--National Institute of Mental Health Collaborative Study.

A family study of psychiatric disorders in 2,003 first-degree relatives of 335 probands found increased rates of bipolar I disorder and major depression (MD) in the relatives of probands with bipolar disorder and increased rates of MD in the relatives of probands with MD. There was a similarity in rates of affective disorders in the relatives of ambulatory and of hospitalized depressed probands (suggesting that ambulatory depressed patients may be as suitable as hospitalized ones for biological studies) and a comparability of rates of illness in relatives between centers for most disorders when comparable diagnostic criteria and procedures were used.

[1]  T. Reich,et al.  MANIC DEPRESSIVE ILLNESS , 1984, The Lancet.

[2]  K. Merikangas,et al.  Panic disorder and major depression. Increased risk of depression, alcoholism, panic, and phobic disorders in families of depressed probands with panic disorder. , 1983, Archives of general psychiatry.

[3]  K. Merikangas,et al.  Anxiety disorders and depression: contradictions between family study data and DSM-III conventions. , 1983, The American journal of psychiatry.

[4]  K. Kidd,et al.  Variability in rates of affective disorders in relatives of depressed and normal probands. , 1982, Archives of general psychiatry.

[5]  K. Merikangas.  Assortative mating for psychiatric disorders and psychological traits. , 1982, Archives of general psychiatry.

[6]  J. Nurnberger,et al.  A family study of schizoaffective, bipolar I, bipolar II, unipolar, and normal control probands. , 1982, Archives of general psychiatry.

[7]  M. Weissman,et al.  Best estimate of lifetime psychiatric diagnosis: a methodological study. , 1982, Archives of general psychiatry.

[8]  M. Baron,et al.  Schizoaffective illness, schizophrenia and affective disorders: morbidity risk and genetic transmission , 1982, Acta Psychiatrica Scandinavica.

[9]  K. Kidd,et al.  Comparison of the family history method to direct interview. Factors affecting the diagnosis of depression. , 1982, Journal of affective disorders.

[10]  M. Tsuang,et al.  The Iowa 500: affective disorder in relatives of manic and depressed patients. , 1982, The American journal of psychiatry.

[11]  B. Jakimow-Venulet.  Hereditary Factors in the Pathogenesis of Affective Illnesses , 1981, British Journal of Psychiatry.

[12]  K. Kidd,et al.  Familial patterns and possible modes of inheritance of primary affective disorders. , 1981, Journal of affective disorders.

[13]  M. Weissman,et al.  Depression and its treatment in a US urban community-1975-1976. , 1981, Archives of general psychiatry.

[14]  M. Taylor,et al.  Reassessing the bipolar-unipolar dichotomy. , 1980, Journal of affective disorders.

[15]  E. Robins,et al.  Prevalence rates for the neuroses: pitfalls in the evaluation of familiality , 1980, Psychological Medicine.

[16]  K. Kidd,et al.  Estimating age-of-onset distributions for disorders with variable onset. , 1980, American journal of human genetics.

[17]  M. Taylor,et al.  The classification of affective disorders--a reassessment of the bipolar-unipolar dichotomy. A clinical, laboratory, and family study. , 1980, Journal of affective disorders.

[18]  J. C. Taylor,et al.  Structural difference between the normal PiM1 and the common PiM2 variant of human alpha 1-antitrypsin. , 1979, American journal of human genetics.

[19]  C. Mazure,et al.  Blindness and reliability in lifetime psychiatric diagnosis. , 1979, Archives of general psychiatry.

[20]  R. Rose,et al.  Life changes. Do people really remember? , 1979, Archives of general psychiatry.

[21]  M. Weissman,et al.  Affective disorders in a US urban community: the use of research diagnostic criteria in an epidemiological survey. , 1978, Archives of general psychiatry.

[22]  E. Robins,et al.  Research diagnostic criteria: rationale and reliability. , 1978, Archives of general psychiatry.

[23]  John Bibby,et al.  The Analysis of Contingency Tables , 1978 .

[24]  M. Weissman,et al.  Psychiatric disorders in a U.S. urban community: 1975-1976. , 1978, The American journal of psychiatry.

[25]  Nancy C. Andreasen,et al.  The family history method using diagnostic criteria , 1978 .

[26]  N C Andreasen,et al.  The family history method using diagnostic criteria. Reliability and validity. , 1977, Archives of general psychiatry.

[27]  W. Bunney,et al.  The inheritance of affective disorders: A review of data and of hypotheses , 1976, Behavior genetics.

[28]  P. Holland,et al.  Discrete Multivariate Analysis. , 1976 .

[29]  E. Gershon,et al.  Genetic models of the transmission of affective disorders , 1975 .

[30]  A. Feinstein,et al.  The importance of classifying initial co-morbidity in evaluating the outcome of diabetes mellitus. , 1974, Journal of chronic diseases.

[31]  J. Myers,et al.  Life events and mental status: a longitudinal study. , 1972, Journal of health and social behavior.

[32]  D. Cox,et al.  The analysis of binary data , 1971 .

[33]  A R Feinstein,et al.  THE PRE-THERAPEUTIC CLASSIFICATION OF CO-MORBIDITY IN CHRONIC DISEASE. , 1970, Journal of chronic diseases.

[34]  H. Akiskal.  Dysthymic disorder: psychopathology of proposed chronic depressive subtypes. , 1983, The American journal of psychiatry.

[35]  K. Kidd.  GENETIC LINKAGE MARKERS IN THE STUDY OF PSYCHIATRIC DISORDERS , 1982 .

[36]  K. Kidd,et al.  An evaluation of the family history method for ascertaining psychiatric disorders. , 1982, Archives of general psychiatry.

[37]  M. Weissman,et al.  Quantifying lifetime risk of psychiatric disorder. , 1981, Journal of psychiatric research.

[38]  J R Kidd,et al.  A procedure for the efficient collection and processing of pedigree data suitable for genetic analysis. , 1979, Journal of psychiatric research.

[39]  M. Weissman,et al.  Sex differences and the epidemiology of depression. , 1977, Archives of general psychiatry.

[40]  G. Klerman,et al.  Treatment setting and clinical depression. , 1970, Archives of general psychiatry.

[41]  S. Guze,et al.  Establishment of diagnostic validity in psychiatric illness: its application to schizophrenia. , 1970, The American journal of psychiatry.