Bone Metastasis in Renal Cell Carcinoma is Preprogrammed in the Primary Tumor and Caused by AKT and Integrin α5 Signaling.

[1]  D. Millerb,et al.  Quantitative in vivo imaging of the effects of inhibiting integrin signaling via Src and FAK on cancer cell movement , 2016 .

[2]  S. Doty,et al.  Curcumin Inhibits Prostate Cancer Bone Metastasis by Up-Regulating Bone Morphogenic Protein-7 in Vivo. , 2014, Journal of cancer therapy.

[3]  K. Junker,et al.  High calcium concentration in bones promotes bone metastasis in renal cell carcinomas expressing calcium-sensing receptor , 2014, Molecular Cancer.

[4]  P. Tamboli,et al.  Cadherin-11 in Renal Cell Carcinoma Bone Metastasis , 2014, PloS one.

[5]  A. Marx,et al.  Circulating fibronectin controls tumor growth. , 2013, Neoplasia.

[6]  B. Hemmings,et al.  PKB/Akt-dependent regulation of cell motility. , 2013, Journal of the National Cancer Institute.

[7]  E. Lengyel,et al.  A phase II, single-arm study of the anti-α5β1 integrin antibody volociximab as monotherapy in patients with platinum-resistant advanced epithelial ovarian or primary peritoneal cancer. , 2011, Gynecologic oncology.

[8]  Xian Chen,et al.  Steroid receptor coactivator-1 upregulates integrin α₅ expression to promote breast cancer cell adhesion and migration. , 2011, Cancer research.

[9]  F. Roos,et al.  Migration of renal tumor cells depends on dephosphorylation of Shc by PTEN. , 2011, International journal of oncology.

[10]  W. Gregory,et al.  Skeletal complications and survival in renal cancer patients with bone metastases. , 2011, Bone.

[11]  G. Duda,et al.  Toward biomimetic materials in bone regeneration: functional behavior of mesenchymal stem cells on a broad spectrum of extracellular matrix components. , 2010, Journal of biomedical materials research. Part A.

[12]  C. Rancourt,et al.  Ovarian cancer ascites protects from TRAIL-induced cell death through αvβ5 integrin-mediated focal adhesion kinase and Akt activation , 2010, Oncogene.

[13]  D. Livant,et al.  Increased potency of the PHSCN dendrimer as an inhibitor of human prostate cancer cell invasion, extravasation, and lung colony formation , 2010, Clinical & Experimental Metastasis.

[14]  S. Rafii,et al.  The bone marrow vascular niche: home of HSC differentiation and mobilization. , 2005, Physiology.

[15]  Y. Kanemura,et al.  Role of fibronectin-stimulated tumor cell migration in glioma invasion in vivo: clinical significance of fibronectin and fibronectin receptor expressed in human glioma tissues , 1998, Clinical & Experimental Metastasis.

[16]  C. Damsky,et al.  FAK integrates growth-factor and integrin signals to promote cell migration , 2000, Nature Cell Biology.

[17]  K. Sekiguchi,et al.  Alternatively Spliced EDA Segment Regulates Fibronectin-dependent Cell Cycle Progression and Mitogenic Signal Transduction* , 1999, The Journal of Biological Chemistry.

[18]  Tomohiko Maehama,et al.  The Tumor Suppressor, PTEN/MMAC1, Dephosphorylates the Lipid Second Messenger, Phosphatidylinositol 3,4,5-Trisphosphate* , 1998, The Journal of Biological Chemistry.

[19]  B F Boyce,et al.  Evidence for a causal role of parathyroid hormone-related protein in the pathogenesis of human breast cancer-mediated osteolysis. , 1996, The Journal of clinical investigation.