Evaluation of the age related changes in dog brains

Cette etude visait a comparer les resultats d'examens anatomopathologiques de cerveaux de chiens jeunes et vieux. Vingt cerveaux de chiens de plus de 10 ans et 10 cerveaux de 10 chiens de 1-2 ans ont ete analyses. Apres examen macroscopique, des echantillons de tissus ont ete preleves dans le telencephale, le mesencephale et le rombencephale en vue d'investigations histopathologiques et immunohistochimiques. L'examen macroscopique des cerveaux de chiens âges a revele une augmentation de l'epaisseur meningee et de la dilatation ventriculaire. Au microscope, une fibrose du plexus choroide, des meninges et des parois vasculaires aussi que des defauts ependymaire, gliose et des pertes neuronales ont ete observes dans le cerveau des chiens âges. Une analyse semi-quantitative des lames a revele une augmentation statistiquement significative de l'expression de la GFAP et CNPase chez les vieux chiens par rapport aux jeunes chiens (P < 0,01).

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