Our experience with carotid body paragangliomas.

Carotid body paragangliomas (CBP) are rare neoplasms arising from the small chemoreceptor organ in the adventitia of the common carotid bifurcation. The aim of this study is to present the diagnostic process, performed treatment and obtained results in patients with carotid body paragangliomas of the Department of Otolaryngology of Istanbul Education and Research Hospital between March 1997 and November 2008. Retrospective analysis was carried out, based on the medical documentation of 5 patients with carotid body paragangliomas (3 women and 2 men), age range 44 to 68 years with a mean of 59.6 years. Four of the patients were diagnosed and treated with Shamblin type II tumor, one of the patients with type I. Physical examination, radiological evaluation, method of the treatment and post-treatment complications were studied. The most common and single symptom was nonspecific neck mass. Preoperative diagnostic evaluation consisted of a color duplex ultrasonography, computerized tomography with contrast enhancement, magnetic resonance imaging and digital subtraction angiography. In all patients with Shamblin type I and II, blunt dissection of the tumor was conducted smoothly in the subadventitial plane. Postoperative vagus nerve and hypoglossal nerve deficit were reported in one case. Carotid body paraganglioma excision has higher risk of cranial nerve paresis and carotid artery injury, so it requires careful handling and good surgical skills to ensure complete removal.

[1]  S. Aydın,et al.  Carotid Body Tumors and Our Surgical Approaches , 2012, Indian Journal of Otolaryngology and Head & Neck Surgery.

[2]  J. Netterville,et al.  Paragangliomas of the head and neck. , 2004, Oral oncology.

[3]  J. Schipper,et al.  18F-DOPA positron emission tomography for the detection of glomus tumours , 2003, European Journal of Nuclear Medicine and Molecular Imaging.

[4]  J. Strauchen.  Germ-line mutations in nonsyndromic pheochromocytoma. , 2002, The New England journal of medicine.

[5]  B. Baysal.  Hereditary paraganglioma targets diverse paraganglia , 2002, Journal of medical genetics.

[6]  D. Frank,et al.  Combined endovascular and surgical treatment of head and neck paragangliomas—A team approach , 2002, Head & neck.

[7]  J. Kuhn,et al.  Management of Carotid Body Paragangliomas and Review of a 30-Year Experience , 2002, Annals of vascular surgery.

[8]  R. Kline,et al.  Glomus jugulare tumor: Tumor control and complications after stereotactic radiosurgery , 2002, Head & neck.

[9]  S. Feigenberg,et al.  Radiosurgery for paraganglioma of the temporal bone , 2002, Head & neck.

[10]  L. Karnell,et al.  National Cancer Data Base report on malignant paragangliomas of the head and neck , 2002, Cancer.

[11]  H. Alkadhi,et al.  Evaluation of Paragangliomas Presenting as a Cervical Mass on Color‐Coded Doppler Sonography , 2002, The Laryngoscope.

[12]  H. Kotob,et al.  Cervical paragangliomas: diagnosis, management and complications , 2001, The Journal of Laryngology & Otology.

[13]  S. Stringer,et al.  Definitive radiotherapy in the management of chemodectomas arising in the temporal bone, carotid body, and glomus vagale , 2001, Head & neck.

[14]  J. Freischlag,et al.  Carotid Body Tumors: The Role of Preoperative Embolization , 2001, Annals of vascular surgery.

[15]  A. Lalwani,et al.  Molecular Pathogenesis in Sporadic Head and Neck Paraganglioma , 2000, The Laryngoscope.

[16]  L. Lowry,et al.  Vagal paraganglioma: The Jefferson experience , 2000, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.

[17]  M. Biffoni,et al.  Surgical treatment of paragangliomas of the carotid body and other rare localisations. , 1999, The Journal of cardiovascular surgery.

[18]  E. Roeder,et al.  Familial paragangliomas: the emerging impact of molecular genetics on evaluation and management. , 1999, The American journal of otology.

[19]  T. Calcaterra,et al.  Surgical Management of Carotid Body Tumors , 1999, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.

[20]  M. Päivänsalo,et al.  Preoperative Embolization in the Management of Neck Paragangliomas , 1997, The Laryngoscope.

[21]  L. Reilly,et al.  Preoperative embolization of carotid body tumors: When is it appropriate? , 1996, Annals of vascular surgery.

[22]  Vinod K. Anand,et al.  Management of the internal carotid artery during carotid body tumor surgery , 1995, The Laryngoscope.

[23]  E. Myers,et al.  Glomus vagale: Paraganglioma of the vagus nerve , 1994, The Laryngoscope.

[24]  D. Brackmann,et al.  Effects of preoperative embolization on glomus jugulare tumors , 1989, The Laryngoscope.

[25]  R. Troupin,et al.  Bilateral carotid body tumors and cyanotic heart disease. , 1980, AJR. American journal of roentgenology.

[26]  S. Sheps,et al.  Carotid body tumor (chemodectoma). Clinicopathologic analysis of ninety cases. , 1971, American journal of surgery.

[27]  A. Samarrai,et al.  Carotid body tumor (chemodectoma). , 1972, International surgery.