Leptin Is a Negative Independent Predictor of Areal BMD and Cortical Bone Size in Young Adult Swedish Men

The association between leptin and areal BMD has been controversial, and the predictive role of leptin on cortical volumetric BMD and bone size has not previously been studied. We show that leptin is a negative independent predictor of aBMD (DXA), at several measured sites, and of cortical bone size (pQCT) in a large population of young men.

[1]  J. Jürimäe,et al.  Influence of Insulin-Like Growth Factor–1 and Leptin on Bone Mineral Content in Healthy Premenopausal Women , 2006, Experimental biology and medicine.

[2]  D. Mellström,et al.  Association of Amount of Physical Activity With Cortical Bone Size and Trabecular Volumetric BMD in Young Adult Men: The GOOD Study , 2005, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[3]  K. Flegal,et al.  The relative contributions of lean tissue mass and fat mass to bone density in young women. , 2005, Bone.

[4]  J. Pasco,et al.  Femoral neck geometry and hip fracture risk: the Geelong osteoporosis study , 2005, Osteoporosis International.

[5]  D. Mellström,et al.  Free Testosterone Is a Positive, Whereas Free Estradiol Is a Negative, Predictor of Cortical Bone Size in Young Swedish Men: The GOOD Study , 2005, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[6]  D. Mellström,et al.  Age of Attainment of Peak Bone Mass Is Site Specific in Swedish Men—The GOOD Study , 2005, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[7]  J. Eisman,et al.  Contribution of lean tissue mass to the urban-rural difference in bone mineral density , 2005, Osteoporosis International.

[8]  R. Lindsay,et al.  Males Have Larger Skeletal Size and Bone Mass Than Females, Despite Comparable Body Size , 2004, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[9]  T. Constantinidis,et al.  SERUM LEPTIN VALUES IN RELATION TO BONE DENSITY AND GROWTH HORMONE-INSULIN LIKE GROWTH FACTORS AXIS IN HEALTHY MEN , 2004, Archives of andrology.

[10]  O. Pedersen,et al.  Leptin and bone mineral density: a cross-sectional study in obese and nonobese men. , 2003, The Journal of clinical endocrinology and metabolism.

[11]  J. Auwerx,et al.  Leptin: cutting the fat off the bone , 2003, The Lancet.

[12]  E. Lazcano-Ponce,et al.  Peak bone mineral area density and determinants among females aged 9 to 24 years in Mexico , 2003, Osteoporosis International.

[13]  M. Bouxsein,et al.  Predicting the failure load of the distal radius , 2003, Osteoporosis International.

[14]  P. Delmas,et al.  Independent predictors of all osteoporosis-related fractures in healthy postmenopausal women: the OFELY study. , 2003, Bone.

[15]  I. Reid.  Relationships among body mass, its components, and bone. , 2002, Bone.

[16]  A. Claessens,et al.  Association between bone mineral density (DXA), body structure, and body composition in middle‐aged men , 2002, American journal of human biology : the official journal of the Human Biology Council.

[17]  Patricia Ducy,et al.  Leptin Regulates Bone Formation via the Sympathetic Nervous System , 2002, Cell.

[18]  J. Everhart,et al.  Relationship of Serum Leptin Concentration With Bone Mineral Density in the United States Population , 2002, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[19]  B. Burguera,et al.  Is Leptin the Link Between Fat and Bone Mass? , 2002, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[20]  K. Yasuda,et al.  Association between serum leptin concentrations and bone mineral density, and biochemical markers of bone turnover in adult men. , 2001, The Journal of clinical endocrinology and metabolism.

[21]  L. Melton,et al.  Role of serum leptin, insulin, and estrogen levels as potential mediators of the relationship between fat mass and bone mineral density in men versus women. , 2001, Bone.

[22]  D. Skaggs,et al.  Increased Body Weight and Decreased Radial Cross‐Sectional Dimensions in Girls with Forearm Fractures , 2001, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[23]  J. Hopper,et al.  Changes in Body Composition as Determinants of Longitudinal Changes in Bone Mineral Measures in 8 to 26-year-old Female Twins , 2001, Osteoporosis International.

[24]  M. Espallargues,et al.  Identifying Bone-Mass-Related Risk Factors for Fracture to Guide Bone Densitometry Measurements: A Systematic Review of the Literature , 2001, Osteoporosis International.

[25]  D. Grobbee,et al.  Measures of bioavailable serum testosterone and estradiol and their relationships with muscle strength, bone density, and body composition in elderly men. , 2000, The Journal of clinical endocrinology and metabolism.

[26]  H. Weiler,et al.  Percent body fat and bone mass in healthy Canadian females 10 to 19 years of age. , 2000, Bone.

[27]  A. Isidori,et al.  Leptin and aging: correlation with endocrine changes in male and female healthy adult populations of different body weights. , 2000, The Journal of clinical endocrinology and metabolism.

[28]  P. Kopelman.  Obesity as a medical problem , 2000, Nature.

[29]  T. Douchi,et al.  Difference in the effect of adiposity on bone density between pre- and postmenopausal women. , 2000, Maturitas.

[30]  Arndt F Schilling,et al.  Leptin Inhibits Bone Formation through a Hypothalamic Relay A Central Control of Bone Mass , 2000, Cell.

[31]  O. Johnell,et al.  Long-Term Risk of Osteoporotic Fracture in Malmö , 2000, Osteoporosis International.

[32]  A. Vermeulen,et al.  A critical evaluation of simple methods for the estimation of free testosterone in serum. , 1999, The Journal of clinical endocrinology and metabolism.

[33]  C. Christiansen,et al.  Low Body Mass Index Is an Important Risk Factor for Low Bone Mass and Increased Bone Loss in Early Postmenopausal Women , 1999, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[34]  J. Kaufman,et al.  Serum leptin levels in healthy ageing men: are decreased serum testosterone and increased adiposity in elderly men the consequence of leptin deficiency? , 1999, Clinical endocrinology.

[35]  A. Goulding,et al.  Plasma Leptin Values in Relation to Bone Mass and Density and to Dynamic Biochemical Markers of Bone Resorption and Formation in Postmenopausal Women , 1998, Calcified Tissue International.

[36]  A. Hofman,et al.  Hip Fracture Prediction in Elderly Men and Women: Validation in the Rotterdam Study , 1998, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[37]  L. Melton,et al.  Relationship between body composition and bone mass in women , 1996, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[38]  W. Vollmer,et al.  Body weight versus body fat distribution, adiposity, and frame size as predictors of bone density. , 1995, The Journal of clinical endocrinology and metabolism.

[39]  S. Cummings,et al.  Risk factors for hip fracture in white women. Study of Osteoporotic Fractures Research Group. , 1995, The New England journal of medicine.

[40]  R. Marcus,et al.  Correlates of bone mineral density in the postmenopausal estrogen/progestin interventions trial , 1994, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[41]  J J Anderson,et al.  Effects of weight and body mass index on bone mineral density in men and women: The framingham study , 1993, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[42]  S. Cummings,et al.  Bone density at various sites for prediction of hip fractures , 1993, The Lancet.