Akt-dependent Phosphorylation of p27Kip1Promotes Binding to 14-3-3 and Cytoplasmic Localization*
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Takashi Tsuruo | Naoya Fujita | T. Tsuruo | N. Fujita | K. Katayama | Saori Sato | Kazuhiro Katayama | Saori Sato
[1] J. Kato,et al. Degradation of the cyclin-dependent-kinase inhibitor p27Kip1 is instigated by Jab1 , 1999, Nature.
[2] A. Ishida,et al. Involvement of Hsp90 in Signaling and Stability of 3-Phosphoinositide-dependent Kinase-1* , 2002, The Journal of Biological Chemistry.
[3] Herman Yeger,et al. Decreased levels of the cell-cycle inhibitor p27Kip1 protein: Prognostic implications in primary breast cancer , 1997, Nature Medicine.
[4] P. Graves,et al. 14-3-3 Proteins Are Required for Maintenance of Raf-1 Phosphorylation and Kinase Activity , 1998, Molecular and Cellular Biology.
[5] Wilhelm Krek,et al. p45SKP2 promotes p27Kip1 degradation and induces S phase in quiescent cells , 1999, Nature Cell Biology.
[6] E. Lam,et al. Inhibition of the Phosphoinositide 3-Kinase Pathway Induces a Senescence-like Arrest Mediated by p27Kip1 * , 2000, The Journal of Biological Chemistry.
[7] M. Hung,et al. Oncogenic Signals of HER-2/neu in Regulating the Stability of the Cyclin-dependent Kinase Inhibitor p27* , 2000, The Journal of Biological Chemistry.
[8] S. Reed,et al. Regulation of G(1) cyclin-dependent kinases in the mammalian cell cycle. , 2000, Current opinion in cell biology.
[9] Andrea C. Carrano,et al. Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation. , 1999, Genes & development.
[10] L. Di Marcotullio,et al. p27 cytoplasmic localization is regulated by phosphorylation on Ser10 and is not a prerequisite for its proteolysis , 2001, The EMBO journal.
[11] J. Avruch,et al. 14-3-3 Proteins: Active Cofactors in Cellular Regulation by Serine/Threonine Phosphorylation* , 2002, The Journal of Biological Chemistry.
[12] James M. Roberts,et al. Cyclin E-CDK2 is a regulator of p27Kip1. , 1997, Genes & development.
[13] J. Woodgett,et al. Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[14] K. Mimori,et al. p27 expression and gastric carcinoma , 1997, Nature Medicine.
[15] A. Iavarone,et al. Kip/Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-beta. , 1995, Genes & development.
[16] Lewis C Cantley,et al. PI3K: Downstream AKTion Blocks Apoptosis , 1997, Cell.
[17] Hong Sun,et al. p27Kip1 ubiquitination and degradation is regulated by the SCFSkp2 complex through phosphorylated Thr187 in p27 , 1999, Current Biology.
[18] L. Hengst,et al. Translational Control of p27Kip1 Accumulation During the Cell Cycle , 1996, Science.
[19] Michele Pagano,et al. SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27 , 1999, Nature Cell Biology.
[20] D R Alessi,et al. PKB/Akt: a key mediator of cell proliferation, survival and insulin responses? , 2001, Journal of cell science.
[21] M. Eilers,et al. Cyclin E‐mediated elimination of p27 requires its interaction with the nuclear pore‐associated protein mNPAP60 , 2000, The EMBO journal.
[22] K. Nakayama,et al. Phosphorylation of p27 Kip1 on Serine 10 Is Required for Its Binding to CRM1 and Nuclear Export* , 2002, The Journal of Biological Chemistry.
[23] John M. Daly,et al. ErbB2 Potentiates Breast Tumor Proliferation through Modulation of p27Kip1-Cdk2 Complex Formation: Receptor Overexpression Does Not Determine Growth Dependency , 2000, Molecular and Cellular Biology.
[24] T. Tsuruo,et al. Interference with PDK1-Akt survival signaling pathway by UCN-01 (7-hydroxystaurosporine) , 2002, Oncogene.
[25] S. R. Datta,et al. Cellular survival: a play in three Akts. , 1999, Genes & development.
[26] P. Beer-Romero,et al. Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27. , 1995, Science.
[27] A. Newton,et al. Akt/Protein Kinase B Is Regulated by Autophosphorylation at the Hypothetical PDK-2 Site* , 2000, The Journal of Biological Chemistry.
[28] M. Hung,et al. Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells , 2001, Nature Cell Biology.
[29] T. Tsuruo,et al. Modulation of Akt kinase activity by binding to Hsp90. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[30] R. Medema,et al. AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1 , 2000, Nature.
[31] M. Wigler,et al. The lipid phosphatase activity of PTEN is critical for its tumor supressor function. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[32] L. Mayo,et al. A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[33] Hong Sun,et al. PTEN/MMAC1/TEP1 suppresses the tumorigenicity and induces G1 cell cycle arrest in human glioblastoma cells. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[34] M. Kitagawa,et al. Phosphorylation at Serine 10, a Major Phosphorylation Site of p27 Kip1 , Increases Its Protein Stability* , 2000, The Journal of Biological Chemistry.
[35] Tomohiko Maehama,et al. The Tumor Suppressor, PTEN/MMAC1, Dephosphorylates the Lipid Second Messenger, Phosphatidylinositol 3,4,5-Trisphosphate* , 1998, The Journal of Biological Chemistry.
[36] B. Vanhaesebroeck,et al. The PI3K-PDK1 connection: more than just a road to PKB. , 2000, The Biochemical journal.
[37] A. Casamayor,et al. PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2 , 1999, Current Biology.
[38] Bruno Amati,et al. Phosphorylation‐dependent degradation of the cyclin‐dependent kinase inhibitor p27Kip1 , 1997, The EMBO journal.
[39] K. Hirano,et al. Minimal requirements for the nuclear localization of p27(Kip1), a cyclin-dependent kinase inhibitor. , 2000, Biochemical and biophysical research communications.
[40] M. Kitagawa,et al. Down-regulation of p27 Kip1 by Two Mechanisms, Ubiquitin-mediated Degradation and Proteolytic Processing* , 1999, The Journal of Biological Chemistry.
[41] D. Alessi. Discovery of PDK1, one of the missing links in insulin signal transduction. Colworth Medal Lecture. , 2001, Biochemical Society transactions.
[42] W. Ansorge,et al. Cdk2-dependent phosphorylation of p27 facilitates its Myc-induced release from cyclin E/cdk2 complexes , 1997, Oncogene.
[43] James M. Roberts,et al. lnterleukin-2-mediated elimination of the p27Kipl cyclin-dependent kinase inhibitor prevented by rapamycin , 1994, Nature.
[44] James M. Roberts,et al. CDK inhibitors: positive and negative regulators of G1-phase progression. , 1999, Genes & development.
[45] M. Pagano,et al. Regulation of the Cdk inhibitor p27 and its deregulation in cancer , 2000, Journal of cellular physiology.