The Regioselectivity of the Asymmetric Intermolecular Heck Reaction with Planar Chiral Diphosphine–Oxazoline Ferrocenyl Ligands

A series of novel planar chiral diphosphine-oxazoline ferrocenyl ligands were synthesized and used efficiently in the palladium-catalyzed asymmetric intermolecular Heck reaction of 2,3-dihydrofuran with aryl triflate and cyclohexenyl triflate. The tuning of the regioselectivity was realized by means of different palladium precursors and by changing the electronic factor of the ligands. A plausible rationale based on the existed mechanism is provided.